Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Nicholas P. Shinners"'
Autor:
Aaron E. Foster, Mary E. Brandt, Kevin M. Slawin, David M. Spencer, Matthew R. Collinson-Pautz, Pei-Yi Lin, Mariam Khalil, Nicholas P. Shinners, My Linh T. Duong, J. Henri Bayle, Aruna Mahendravada, Wei-Chun Chang, Ming Zhang, An Lu, Jeannette Crisostomo
Publikováno v:
Leukemia
Successful adoptive chimeric antigen receptor (CAR) T-cell therapies against hematological malignancies require CAR-T expansion and durable persistence following infusion. Balancing increased CAR-T potency with safety, including severe cytokine-relea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e30e133078c58b79fdbde0dbc893bc7
https://doi.org/10.1038/s41375-019-0417-9
https://doi.org/10.1038/s41375-019-0417-9
Autor:
Sunandan Saha, Wei-Chun Chang, Aaron E. Foster, Aruna Mahendravada, An Lu, Mariam Khalil, Kevin M. Slawin, Tsvetelina Pentcheva-Hoang, David M. Spencer, Nicholas P. Shinners, Joanne L. Shaw, My Linh T. Duong, David Torres, J. Henri Bayle, Matthew R. Collinson-Pautz, Jeannette Crisostomo, Eva Morschl, Tania Veliz Rodriguez
Publikováno v:
Molecular therapy : the journal of the American Society of Gene Therapy. 25(9)
Anti-tumor efficacy of T cells engineered to express chimeric antigen receptors (CARs) is dependent on their specificity, survival, and in vivo expansion following adoptive transfer. Toll-like receptor (TLR) and CD40 signaling in T cells can improve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfac6f110570e59ef012b52e5c6d1100
https://pubmed.ncbi.nlm.nih.gov/28830671
https://pubmed.ncbi.nlm.nih.gov/28830671
Autor:
Stefan Köhrer, Ondrej Havranek, R. Eric Davis, Wencai Ma, Anusha R. Karri, Tomasz Zal, John Man Chun Ma, Luhong Sun, Justin M Comer, Allen F. Yi, Lisa M. Becker, Nicholas P. Shinners, Jingda Xu, Jason R. Westin, Jared Henderson, Zhiqiang Wang, Dipanjan Ghosh, Jan A. Burger
Publikováno v:
Blood. 130(8)
We used clustered regularly interspaced short palindromic repeats/Cas9-mediated genomic modification to investigate B-cell receptor (BCR) signaling in cell lines of diffuse large B-cell lymphoma (DLBCL). Three manipulations that altered BCR genes wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89d78b587617da99671b12f859d90747
https://pubmed.ncbi.nlm.nih.gov/28646116
https://pubmed.ncbi.nlm.nih.gov/28646116
Autor:
Ramnik J. Xavier, Bo Zhao, Fadi Towfic, Kaoru Takasaki, Nicholas P. Shinners, Jessica C. Mar, Elliott Kieff, Benjamin E. Gewurz, John Quackenbush, Ellen Cahir-McFarland
Publikováno v:
Proceedings of the National Academy of Sciences. 109:2467-2472
Although canonical NFκB is frequently critical for cell proliferation, survival, or differentiation, NFκB hyperactivation can cause malignant, inflammatory, or autoimmune disorders. Despite intensive study, mammalian NFκB pathway loss-of-function
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e3bb021c74d4b141f479ce67d0582b8
https://doi.org/10.1073/pnas.1120542109
https://doi.org/10.1073/pnas.1120542109
Autor:
Edward Bedoya, Elliott Kieff, John Quackenbush, Kaoru Takasaki, Jessica C. Mar, James Y. Zou, Megha Padi, Benjamin E. Gewurz, Bo Zhao, Ellen Cahir-McFarland, Nicholas P. Shinners
Publikováno v:
Journal of Virology. 85:6764-6773
Epstein-Barr virus (EBV) latent membrane protein 1 (LMP1) transforms rodent fibroblasts and is expressed in most EBV-associated malignancies. LMP1 ( t ransformation e ffector s ite 2 [TES2]/C-terminal activation region 2 [CTAR2]) activates NF-κB, p3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c63903713af290d586874e53daca0b4
https://doi.org/10.1128/jvi.00422-11
https://doi.org/10.1128/jvi.00422-11
Autor:
Pierre Antony, John J. Lowe, Wasif N. Khan, James B. Petro, Gianluca Carlesso, Nicholas P. Shinners
Publikováno v:
Experimental Cell Research. 291:11-24
BCR engagement initiates intracellular calcium ([Ca2+]i) mobilization which is critical for the activation of multiple transcription factors including NF-kappaB and NFAT. Previously, we showed that Bruton's tyrosine kinase (BTK)-deficient (btk-/-) B
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1189a40e13ecc8b7aa6bf99952b27e78
https://doi.org/10.1016/s0014-4827(03)00338-0
https://doi.org/10.1016/s0014-4827(03)00338-0
Autor:
David M. Spencer, Peter Chang, J. Henri Bayle, Aaron E. Foster, Nicholas P. Shinners, An Lu, Aruna Mahendravada, Kevin M. Slawin, MyLinh Duong
Publikováno v:
Blood. 128:4551-4551
Introduction: Promising clinical results with CD19-specific chimeric antigen receptor (CAR)-directed T cells for the treatment of B cell leukemia and lymphoma suggest that CARs may be effective in other hematological malignancies, such as acute myelo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f421dc4a89d41f1b7d274bb3d3057657
https://doi.org/10.1182/blood.v128.22.4551.4551
https://doi.org/10.1182/blood.v128.22.4551.4551
Autor:
Wasif N. Khan, Nicholas P. Shinners, Pierre Antony, James B. Petro, John J. Lowe, Gianluca Carlesso
Publikováno v:
Biochemical Society Transactions. 32:113-115
Engagement of the B-cell antigen receptor (BCR) induces the activation of various transcription factors, including NFAT (nuclear factor of activated T-cells) and NF-kappaB (nuclear factor kappaB), which participate in long-term biological responses s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::644270d188234ae3f7532f9f215f05b7
https://doi.org/10.1042/bst0320113
https://doi.org/10.1042/bst0320113
Autor:
Peter Chang, Aaron E. Foster, Jeannette Crisostomo, David M. Spencer, Eva Morschl, Joanne Shaw, Nicholas P. Shinners, Sunandan Saha, Kevin M. Slawin, Aruna Mahendravada, An Lu
Publikováno v:
Journal of Clinical Oncology. 34:206-206
206 Background: PSCA is a cell surface antigen that is overexpressed in a majority of metastatic prostate, transitional cell and pancreatic carcinomas. We describe a novel T cell costimulation switch, inducible MyD88/CD40 (iMC), activated by a small
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5a6c998e9caab7921d90e4e9e94dc94c
https://doi.org/10.1200/jco.2016.34.2_suppl.206
https://doi.org/10.1200/jco.2016.34.2_suppl.206
Autor:
Peter Chang, Nicholas P. Shinners, Aruna Mahendravada, Sunandan Saha, An Lu, Kevin M. Slawin, Joanne Shaw, David M. Spencer, Eva Morschl, Aaron E. Foster
Publikováno v:
Blood. 126:4295-4295
Introduction: Adoptive transfer of T cells, genetically engineered to express chimeric antigen receptors (CARs) containing costimulatory domains, such as CD28 or 4-1BB, has yielded impressive clinical results in some blood cancers, but severe toxicit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1ca01a4cb4682ba7c5474c5ffb6bac42
https://doi.org/10.1182/blood.v126.23.4295.4295
https://doi.org/10.1182/blood.v126.23.4295.4295