Neurotoxic amyloidogenic peptides in the proteome of SARS-COV2: potential implications for neurological symptoms in COVID-19

Autor: Mirren Charnley, Saba Islam, Guneet K. Bindra, Jeremy Engwirda, Julian Ratcliffe, Jiangtao Zhou, Raffaele Mezzenga, Mark D. Hulett, Kyunghoon Han, Joshua T. Berryman, Nicholas P. Reynolds

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)

Here the authors report the formation of toxic clumps of protein, similar to amyloid assemblies found in Alzheimer’s disease and suggest their possible role for some of the neurological symptoms of long-COVID.

Externí odkaz: https://doaj.org/article/31ac39f0f9b2477098afc51ae04937ba

Competition between crystal and fibril formation in molecular mutations of amyloidogenic peptides

Autor: Nicholas P. Reynolds, Jozef Adamcik, Joshua T. Berryman, Stephan Handschin, Ali Asghar Hakami Zanjani, Wen Li, Kun Liu, Afang Zhang, Raffaele Mezzenga

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)

Aggregation of amyloidogenic peptides into fibrils and crystals has incidence in several amyloid-related diseases. Here, the authors investigate the origins of the fibril-to-crystal conversion in amyloidogenic hexapeptides pointing to the amyloid cry

Externí odkaz: https://doaj.org/article/f724699c0cff4d61b17cab20071aad41

Towards using 3D cellular cultures to model the activation and diverse functions of macrophages

Autor: Sean Cutter, Mark D. Wright, Nicholas P. Reynolds, Katrina Jean Binger

Publikováno v: Biochemical Society Transactions. 51:387-401

The advent of 3D cell culture technology promises to enhance understanding of cell biology within tissue microenvironments. Whilst traditional cell culturing methods have been a reliable tool for decades, they inadequately portray the complex environ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::95249157bf53d3852347d8494e76d025
https://doi.org/10.1042/bst20221008

Lipid membrane-mediated assembly of the functional amyloid-forming peptide Somatostatin-14

Autor: Varun Prasath, Jiali Zhai, Brendan P. Dyett, Haitao Yu, Søren V. Hoffmann, Nykola C. Jones, Nicholas P. Reynolds, Céline Valéry, Calum J. Drummond, Charlotte E. Conn

Publikováno v: Prasath, V, Zhai, J, Dyett, B P, Yu, H, Hoffmann, S V, Jones, N C, Reynolds, N P, Valery, C, Drummond, C J & Conn, C E 2022, ' Lipid membrane-mediated assembly of the functional amyloid-forming peptide Somatostatin-14 ', Biophysical Chemistry . https://doi.org/10.1016/j.bpc.2022.106830

Membrane-mediated assembly has been well characterised for toxic amyloid species such as the amyloid-β peptide implicated in Alzheimer's disease. However, little is known about the membrane-mediated assembly of functional-amyloid forming peptides, r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::659a8c1bbf81f1255b6a4f066838e1f4
https://pubmed.ncbi.nlm.nih.gov/35635892

Neurotoxic Amyloidogenic Peptides Identified in the Proteome of SARS-COV2: Potential Implications for Neurological Symptoms in COVID-19

Autor: Mark D. Hulett, Jiangtao Zhou, Raffaele Mezzenga, Julian Ratcliffe, Joshua T. Berryman, Guneet K. Bindra, Saba Islam, Mirren Charnley, Kyunghoon Han, Nicholas P. Reynolds

COVID-19 is primarily known as a respiratory disease caused by the virus SARS-CoV-2. However, neurological symptoms such as memory loss, sensory confusion, cognitive and psychiatric issues, severe headaches, and even stroke are reported in as many as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::881ea0d13249b048c35bd9d11fbf5676
https://doi.org/10.1101/2021.11.24.469537