Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Nicholas P. Raybould"'
Autor:
Peter Laslo, Nicholas P. Raybould, Denise Greenwood, Christian Soeller, Mark B. Cannell, Noriyuki Hoya, Gary D. Housley, Refik Kanjhan, Daniel J. Jagger
Publikováno v:
The Journal of Physiology. 579:101-113
Ca2+ signalling is central to cochlear sensory hair cell physiology through its influence on sound transduction, membrane filter properties and neurotransmission. However, the mechanism for establishing Ca2+ homeostasis in these cells remains unresol
Publikováno v:
Audiology and Neurotology. 8:115-128
Extracellular adenosine 5′-triphosphate (ATP)-gated ion channels assembled from P2X receptor subunits exhibit subunit-selective allosteric modulation by protons and divalent cations. In voltage-clamped guinea-pig cochlear outer hair cells (OHC) and
Autor:
Denise Greenwood, Leif Järlebark, Srdjan M. Vlajkovic, Gary D. Housley, Peter R. Thorne, Predrag Nikolic, Daniel J. Jagger, D.J.M. Muñoz, Refik Kanjhan, Nicholas P. Raybould, Salam G. Salih
Publikováno v:
Audiology and Neurotology. 7:55-61
In the cochlea, extracellular ATP influences the endocochlear potential, micromechanics, and neurotransmission via P2 receptors. Evidence for this arises from studies demonstrating widespread expression of ATP-gated ion channels (assembled from P2X r
Publikováno v:
NeuroReport. 9:2467-2474
Reissner's membrane forms a partition between the endolymphatic and perilymphatic cochlear compartments. Expression of the P2X2 receptor subunit which assembles to form ATP-gated ion channels was detected in guinea-pig Reissner's membrane using the r
Publikováno v:
Neuroreport. 13(15)
Extracellular ATP has several neuro-humoral actions on cochlear physiology, many of which involve P2X receptor-mediated signal transduction. The present study extends the molecular physiology of P2X 2 receptor gene expression in the cochlea to the pr
Publikováno v:
Audiologyneuro-otology. 8(3)
Extracellular adenosine 5'-triphosphate (ATP)-gated ion channels assembled from P2X receptor subunits exhibit subunit-selective allosteric modulation by protons and divalent cations. In voltage-clamped guinea-pig cochlear outer hair cells (OHC) and D
Publikováno v:
Journal of the Association for Research in Otolaryngology : JARO. 2(4)
In mammals, sound transduction by inner hair cells (IHC) generates a receptor potential whose amplitude and phase drive auditory nerve firing. The membrane filter properties that define the input-output function of IHC are derived from membrane condu
Publikováno v:
Neuroreport. 10(12)
Extracellular ATP acts via ionotropic P2X receptors to mediate fast neurotransmission in the central and autonomic nervous systems. Recent data, including identification of P2X2 receptor mRNA expression by spiral ganglion neurones, suggests that puri
Variation in expression of the outer hair cell P2X receptor conductance along the guinea-pig cochlea
Autor:
Gary D. Housley, Nicholas P. Raybould
Publikováno v:
The Journal of physiology. 498
1. Whole-cell patch-clamp recordings were used to determine the variation in the P2X receptor conductance, activated by extracellular ATP, in outer hair cells (OHCs) isolated from each of the four turns of the guinea-pig cochlea. 2. In standard solut
Autor:
Salam G. Salih, Leif Jarlebark, Vera C. M. Setz, Mark B. Cannell, Haruhide Yoshie, Shin-ichi Usami, Denise Greenwood, Christian Soeller, Lucille D. Burton, Gary D. Housley, Atsushi Matsubara, Peter R. Thorne, Refik Kanjhan, Nicholas P. Raybould, David L. Christie, Allen F. Ryan
Publikováno v:
Europe PubMed Central
Extracellular ATP has multimodal actions in the cochlea affecting hearing sensitivity. ATP-gated ion channels involved in this process were characterized in the guinea pig cochlea. Voltage-clamped hair cells exhibited a P2 receptor pharmacology compa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8401768e150c7d12b139c06d769918b8
http://europepmc.org/abstract/med/10493739
http://europepmc.org/abstract/med/10493739