Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Nicholas P. Poolos"'
Autor:
Nicholas P. Poolos, M.N. Khan, F.A. Concepcion, A. Dhami, R.D. Boehm, O.C. Poolos, A.N. Parikh
Publikováno v:
IBRO Reports, Vol 8, Iss, Pp 48-55 (2020)
IBRO Reports
IBRO Reports
c-Jun N-terminal kinases (JNKs) are members of the mitogen-activated protein kinase (MAPK) family and are derived from three genes, Jnk1-3. These kinases are involved in cellular responses to homeostatic insults, such as inflammation and apoptosis. F
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b778c3e3fc011a50feadd55cb15da8a
http://www.sciencedirect.com/science/article/pii/S2451830120300029
http://www.sciencedirect.com/science/article/pii/S2451830120300029
Publikováno v:
Epilepsy & Behavior. 138:109055
Some patients who initially fail epilepsy surgery later become seizure-free, but it is not clear how the clinical characteristics of the patients or post-operative modifications of anti-seizure medication (ASM) regimens contribute to late seizure rem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c75dfc8bb9762f8803ad6b973ba84607
https://doi.org/10.1016/j.yebeh.2022.109055
https://doi.org/10.1016/j.yebeh.2022.109055
Autor:
Y Shi, Jan-Marino Ramirez, Nicholas P. Poolos, Jimmy K. Eng, Jeffrey G. Ojemann, M.N. Khan, F.A. Concepcion, Aguan Wei, J-D Ju Wang, Andrew L. Ko
Publikováno v:
Neuroscience
Because hyperpolarization-activated cyclic nucleotide-gated (HCN) ion channels modulate the excitability of cortical and hippocampal principal neurons, these channels play a key role in the hyperexcitability that occurs during the development of epil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc306a4a637ecaaa605c059a8b832b03
https://pubmed.ncbi.nlm.nih.gov/33571596
https://pubmed.ncbi.nlm.nih.gov/33571596
Publikováno v:
The Journal of Physiology. 593:2779-2792
Key points Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels, particularly that of the HCN1 isoform, are enriched in the distal dendrites of hippocampal CA1 pyramidal neurons; these channels have physiological functions with respect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9a37f9ca8c7f669ac598eeeaf5727ba7
https://doi.org/10.1113/jp270453
https://doi.org/10.1113/jp270453
Autor:
Daniel Johnston, Nicholas P. Poolos
Publikováno v:
Epilepsia. 53:32-40
SUMMARY Ion channel dysfunction or ‘‘channelopathy’’ is a proven cause of epilepsy in the relatively uncommon genetic epilepsies with Mendelian inheritance. But numerous examples of acquired channelopathy in experimental animal models of epil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e24df9ecb22adb34404ac2b5e3c4d40e
https://doi.org/10.1111/epi.12033
https://doi.org/10.1111/epi.12033
Autor:
Stephen R. Williams, Christina E. Castagna, Nicholas P. Poolos, Tyler J. Story, Alison B. Miller
Publikováno v:
Epilepsybehavior : EB. 69
Seizures in patients with medically refractory epilepsy remain a substantial clinical challenge, not least because of the dearth of evidence-based guidelines as to which antiepileptic drug (AED) regimens are the most effective, and what doses of thes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1ad5bb18d37935986d0a74ce84dad3c
https://pubmed.ncbi.nlm.nih.gov/28235655
https://pubmed.ncbi.nlm.nih.gov/28235655
Autor:
John W. Miller, Nicholas P. Poolos, Raimondo D'Ambrosio, Joaquin N. Lugo, Aaron H. Sheerin, Terrance D. Jones, Sangwook Jung, Anne E. Anderson
Publikováno v:
The Journal of Neuroscience. 27:13012-13021
Ion channelopathy plays an important role in human epilepsy with a genetic cause and has been hypothesized to occur in epilepsy after acquired insults to the CNS as well. Acquired alterations of ion channel function occur after induction of status ep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c543cf8f933d8c4bfd95535ea21aec47
https://doi.org/10.1523/jneurosci.3605-07.2007
https://doi.org/10.1523/jneurosci.3605-07.2007
Publikováno v:
The Journal of Physiology. 579:431-443
In CA1 and neocortical pyramidal neurons, Ih is present primarily in the dendrites. We asked if all neurons of a pyramidal morphology have a similar density of Ih. We characterized a novel class of hippocampal neurons with pyramidal morphology found
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::48337720bc549bb42433ff23eb29877f
https://doi.org/10.1113/jphysiol.2006.123836
https://doi.org/10.1113/jphysiol.2006.123836
Autor:
David W. Skyrud, Aaron D. Williams, Lindsay N. Warner, Nicholas P. Poolos, Jason S. Fender, Raimondo D'Ambrosio, Yusha Liu, Sangwook Jung, Tina Y. Tai, John F. Neumaier, Francis A. Concepcion, Terrance D. Jones
Publikováno v:
Neuroscience. 349
Several phosphorylation signaling pathways have been implicated in the pathogenesis of epilepsy arising from both genetic causes and acquired insults to the brain. Identification of dysfunctional signaling pathways in epilepsy may provide novel targe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d054a06049737886edab0dae8e004314
https://pubmed.ncbi.nlm.nih.gov/28237815
https://pubmed.ncbi.nlm.nih.gov/28237815