Zobrazeno 1 - 10
of 120
pro vyhledávání: '"Nicholas P. Lockyer"'
Publikováno v:
Plants, Vol 11, Iss 9, p 1234 (2022)
The detection of chemical species and understanding their respective localisations in tissues have important implications in plant science. The conventional methods for imaging spatial localisation of chemical species are often restricted by the numb
Externí odkaz:
https://doaj.org/article/3accd34138494679b76559c552046acb
Autor:
Joanna L. Denbigh, David Perez-Guaita, Robbin R. Vernooij, Mark J. Tobin, Keith R. Bambery, Yun Xu, Andrew D. Southam, Farhat L. Khanim, Mark T. Drayson, Nicholas P. Lockyer, Royston Goodacre, Bayden R. Wood
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Abstract Acute myeloid leukaemia (AML) is a life threatening cancer for which there is an urgent clinical need for novel therapeutic approaches. A redeployed drug combination of bezafibrate and medroxyprogesterone acetate (BaP) has shown anti-leukaem
Externí odkaz:
https://doaj.org/article/ac60fdf6ada446ecbc4c12809e9d4109
Autor:
Hua Tian, John S. Fletcher, Raphael Thuret, Alex Henderson, Nancy Papalopulu, John C. Vickerman, Nicholas P. Lockyer
Publikováno v:
Journal of Lipid Research, Vol 55, Iss 9, Pp 1970-1980 (2014)
Time-of-flight secondary ion mass spectrometry (ToF-SIMS) imaging has been used for the direct analysis of single intact Xenopus laevis embryo surfaces, locating multiple lipids during fertilization and the early embryo development stages with subcel
Externí odkaz:
https://doaj.org/article/9584a651e652446fb60d99d886e4bf64
Autor:
Ehsan Gazi, Peter Gardner, Nicholas P. Lockyer, Claire A. Hart, Michael D. Brown, Noel W. Clarke
Publikováno v:
Journal of Lipid Research, Vol 48, Iss 8, Pp 1846-1856 (2007)
Various epidemiological studies show a positive correlation between high intake of dietary FAs and metastatic prostate cancer (CaP). Moreover, CaP metastasizes to the bone marrow, which harbors a rich source of lipids stored within adipocytes. Here,
Externí odkaz:
https://doaj.org/article/7f9263f6f75b4fce881164fe54319a23
Autor:
Mojtaba Abdi-Jalebi, Weiwei Li, Francesco Di Giacomo, Nicholas P. Lockyer, Felix Utama Kosasih, Katie L. Moore, Jordi Ferrer Orri, Elizabeth M. Tennyson, Fabio Matteocci, Caterina Ducati, Judith Driscoll, Samuel D. Stranks, Narges Yaghoobi Nia, Giorgio Divitini, Aldo Di Carlo, Kexue Li
Publikováno v:
Proceedings of the 13th Conference on Hybrid and Organic Photovoltaics.
Publikováno v:
Alnajeebi, A M, Vickerman, J & Lockyer, N 2018, ' The influence of polyatomic primary ion chemistry on matrix effects in secondary ion mass spectrometry analysis ', Rapid Communications in Mass Spectrometry, vol. 32, no. 22, pp. 1962-1970 . https://doi.org/10.1002/rcm.8265
RATIONALE The application of mass spectrometry imaging techniques to determine two- (2D) and three- (3D) dimensional chemical distribution ideally provides uniform, high sensitivity to multiple components and reliable quantification. These criteria a
Autor:
Danielle McDougall, Malama Chisanga, Nicholas P. Lockyer, Howbeer Muhamadali, Yun Xu, Royston Goodacre
Publikováno v:
The Analyst
Microbial communities play essential functions which drive various ecosystems supporting animal and aquatic life. However, linking bacteria with specific metabolic functions is difficult, since microbial communities consist of numerous and phylogenet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c3936f3f05ee26ef504d7642de45492
Publikováno v:
Aldossari, S, Mcmahon, G, Lockyer, N & Moore, K 2019, ' Microdistribution and quantification of the boron neutron capture therapy drug BPA in primary cell cultures of human glioblastoma tumour by NanoSIMS ', The Analyst . https://doi.org/10.1039/C9AN01336A
The ability of secondary ion mass spectrometry (SIMS) to provide high sensitivity imaging of elements and small-medium mass molecules in biological tissues and cells, makes it a very powerful tool for drug distribution studies. Here we report on the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28e8e601ff3eed3b13d5f87087820e7e
https://www.research.manchester.ac.uk/portal/en/publications/microdistribution-and-quantification-of-the-boron-neutron-capture-therapy-drug-bpa-in-primary-cell-cultures-of-human-glioblastoma-tumour-by-nanosims(f1c0779b-88e3-4405-b0d2-fa514e2e1072).html
https://www.research.manchester.ac.uk/portal/en/publications/microdistribution-and-quantification-of-the-boron-neutron-capture-therapy-drug-bpa-in-primary-cell-cultures-of-human-glioblastoma-tumour-by-nanosims(f1c0779b-88e3-4405-b0d2-fa514e2e1072).html
Publikováno v:
Palaeontology
McNamara, M E, Van Dongen, B E, Lockyer, N P, Bull, I D & Orr, P J 2016, ' Fossilization of melanosomes via sulfurization ', Palaeontology, vol. 59, no. 3, pp. 337-350 . https://doi.org/10.1111/pala.12238
McNamara, M E, Van Dongen, B E, Lockyer, N P, Bull, I D & Orr, P J 2016, ' Fossilization of melanosomes via sulfurization ', Palaeontology, vol. 59, no. 3, pp. 337-350 . https://doi.org/10.1111/pala.12238
Fossil melanin granules (melanosomes) are an important resource for inferring the evolutionary history of colour and its functions in animals. The taphonomy of melanin and melanosomes, however, is incompletely understood. In particular, the chemical
Publikováno v:
Rapid Communications in Mass Spectrometry. 29:1851-1862
RATIONALE To discover the degree to which water-containing cluster beams increase secondary ion yield and reduce the matrix effect in time-of-flight secondary ion mass spectrometry (TOF-SIMS) imaging of biological tissue. METHODS The positive SIMS io