Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Nicholas P Whitehead"'
Publikováno v:
PLoS ONE, Vol 5, Iss 12, p e15354 (2010)
Recent studies have shown that oxidative stress contributes to the pathogenesis of muscle damage in dystrophic (mdx) mice. In this study we have investigated the role of NADPH oxidase as a source of the oxidative stress in these mice. The NADPH oxida
Externí odkaz:
https://doaj.org/article/826629b012794c32807243f67805b67e
Publikováno v:
Journal of neuromuscular diseases. 8(5)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d07f5cc6a6ff192dffdeb81d299f4a98
https://pubmed.ncbi.nlm.nih.gov/34542081
https://pubmed.ncbi.nlm.nih.gov/34542081
Autor:
Min Jeong Kim, Kenneth L. Bible, Stanley C. Froehner, Nicholas P. Whitehead, Guy L. Odom, Marvin E. Adams
Publikováno v:
The Journal of Physiology. 594:7215-7227
Key points Duchenne muscular dystrophy (DMD) is a severe, degenerative muscle disease that is commonly studied using the mdx mouse. The mdx diaphragm muscle closely mimics the pathophysiological changes in DMD muscles. mdx diaphragm force is commonly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1a9da766b7c3f3feaf7d75d7f022f84e
https://doi.org/10.1113/jp272707
https://doi.org/10.1113/jp272707
Publikováno v:
Human molecular genetics. 28(3)
Syntrophins are a family of modular adaptor proteins that are part of the dystrophin protein complex, where they recruit and anchor a variety of signaling proteins. Previously we generated mice lacking α- and/or β2-syntrophin but showed that in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc57848ad863306ebde67eab5688170f
https://pubmed.ncbi.nlm.nih.gov/30256963
https://pubmed.ncbi.nlm.nih.gov/30256963
Autor:
Kenneth L. Bible, Stanley C. Froehner, Michael Regnier, Marvin E. Adams, Nicholas P. Whitehead, Min J. Kim
Publikováno v:
Physiological Reports, Vol 7, Iss 6, Pp n/a-n/a (2019)
Physiological Reports
Physiological Reports
Duchenne muscular dystrophy (DMD), caused by absence of the protein dystrophin, is a common, degenerative muscle disease affecting 1:5000 males worldwide. With recent advances in respiratory care, cardiac dysfunction now accounts for 50% of mortality
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc4bb1a20c28216ec3a66bc9b5379bfa
https://doi.org/10.14814/phy2.14018
https://doi.org/10.14814/phy2.14018
Autor:
Nicholas P, Whitehead, Kenneth L, Bible, Min Jeong, Kim, Guy L, Odom, Marvin E, Adams, Stanley C, Froehner
Publikováno v:
The Journal of physiology. 594(24)
Duchenne muscular dystrophy (DMD) is a severe, degenerative muscle disease that is commonly studied using the mdx mouse. The mdx diaphragm muscle closely mimics the pathophysiological changes in DMD muscles. mdx diaphragm force is commonly assessed e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4d0cea466c18fbbd8b244d1b5189ab73
https://pubmed.ncbi.nlm.nih.gov/27976400
https://pubmed.ncbi.nlm.nih.gov/27976400
Publikováno v:
Rare Diseases
Duchenne muscular dystrophy (DMD) is the most common and severe inherited neuromuscular disorder. DMD is caused by mutations in the gene encoding the dystrophin protein in muscle fibers. Dystrophin was originally proposed to be a structural protein t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4074277b3dbc9caba74db4ca56014fda
http://europepmc.org/articles/PMC4838314
http://europepmc.org/articles/PMC4838314
Autor:
Nicholas P. Whitehead, Evanthia Nanou, Min Jeong Kim, Jin Yan, William A. Catterall, Stanley C. Froehner, Todd Scheuer
Facilitation and inactivation of P/Q-type calcium (Ca(2+)) currents through the regulation of voltage-gated Ca(2+) (CaV) 2.1 channels by Ca(2+) sensor (CaS) proteins contributes to the facilitation and rapid depression of synaptic transmission in cul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3c1c1b1890420814b32b2b81db58549
https://europepmc.org/articles/PMC4743804/
https://europepmc.org/articles/PMC4743804/
Autor:
Justin M. Percival, Candace M. Adamo, Joseph A. Beavo, Stanley C. Froehner, Nicholas P. Whitehead, Marvin E. Adams
Publikováno v:
The Journal of Pathology. 228:77-87
Duchenne muscular dystrophy (DMD) is the most common form of muscular dystrophy caused by mutations in the dystrophin gene. Loss of dystrophin initiates a progressive decline in skeletal muscle integrity and contractile capacity which weakens respira
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::54c01810b940c429220a36783601016e
https://doi.org/10.1002/path.4054
https://doi.org/10.1002/path.4054
Autor:
David G. Allen, Othon L. Gervásio, Bao-Ting Zhang, Diane Fatkin, Ella W. Yeung, Trent F. Reardon, Molly Vale, Nicholas P. Whitehead, Alexander Dietrich
Publikováno v:
Journal of Applied Physiology. 112:2077-2086
Muscles that are stretched during contraction (eccentric contractions) show deficits in force production and a variety of structural changes, including loss of antibody staining of cytoskeletal proteins. Extracellular Ca2+ entry and activation of cal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b59fb3ad599e6d4d8ece70c602dc0c66
https://doi.org/10.1152/japplphysiol.00770.2011
https://doi.org/10.1152/japplphysiol.00770.2011