Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Nicholas P Lesner"'
Autor:
Nicholas P Lesner, Xun Wang, Zhenkang Chen, Anderson Frank, Cameron J Menezes, Sara House, Spencer D Shelton, Andrew Lemoff, David G McFadden, Janaka Wansapura, Ralph J DeBerardinis, Prashant Mishra
Publikováno v:
eLife, Vol 11 (2022)
Mitochondrial electron transport chain (ETC) dysfunction due to mutations in the nuclear or mitochondrial genome is a common cause of metabolic disease in humans and displays striking tissue specificity depending on the affected gene. The mechanisms
Externí odkaz:
https://doaj.org/article/bc53e8466ccf4687be0151852c83aa36
Autor:
Xun Wang, Yuemeng Jia, Jiawei Zhao, Nicholas P. Lesner, Cameron J. Menezes, Spencer D. Shelton, Siva Sai Krishna Venigalla, Jian Xu, Chunyu Cai, Prashant Mishra
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 23 (2022)
A fundamental issue in regenerative medicine is whether there exist endogenous regulatory mechanisms that limit the speed and efficiency of the repair process. We report the existence of a maturation checkpoint during muscle regeneration that pauses
Externí odkaz:
https://doaj.org/article/15b0cd65a0394ce191cd116aa3a38eda
Autor:
Abhimanyu Garg, Wee-Teik Keng, Zhenkang Chen, Adwait Amod Sathe, Chao Xing, Pavithira Devi Kailasam, Yanqiu Shao, Nicholas P. Lesner, Claire B. Llamas, Anil K. Agarwal, Prashant Mishra
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 23 (2022)
Multiple genetic loci have been reported for progeroid syndromes. However, the molecular defects in some extremely rare forms of progeria have yet to be elucidated. Here, we report a 21-year-old man of Chinese ancestry who has an autosomal recessive
Externí odkaz:
https://doaj.org/article/486f4ee4357c45cca2ea1e35adcccde2
Publikováno v:
The EMBO Journal. 42
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d9c9019b9852d3ab0182a4e071fa08da
https://doi.org/10.15252/embj.2022112067
https://doi.org/10.15252/embj.2022112067
Autor:
Divya Bezwada, Nicholas P. Lesner, Bailey Brooks, Hieu S. Vu, Zheng Wu, Ling Cai, Stacy Kasitinon, Sherwin Kelekar, Feng Cai, Arin B. Aurora, McKenzie Patrick, Ashley Leach, Rashed Ghandour, Yuanyuan Zhang, Duyen Do, Jessica Sudderth, Dennis Dumesnil, Sara House, Tracy Rosales, Alan M. Poole, Yair Lotan, Solomon Woldu, Aditya Bagrodia, Xiaosong Meng, Jeffrey A. Cadeddu, Prashant Mishra, Ivan Pedrosa, Payal Kapur, Kevin D. Courtney, Craig R. Malloy, Vitaly Margulis, Ralph J. DeBerardinis
Publikováno v:
bioRxiv
SummaryMost kidney cancers display evidence of metabolic dysfunction1–4but how this relates to cancer progression in humans is unknown. We used a multidisciplinary approach to infuse13C-labeled nutrients during surgical tumour resection in over 70
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b6d2448d68a99890c9685f4d79bf794
https://doi.org/10.1101/2023.02.06.527285
https://doi.org/10.1101/2023.02.06.527285
Autor:
Zhenkang Chen, Bogdan Bordieanu, Rushendhiran Kesavan, Nicholas P. Lesner, Siva Sai Krishna Venigalla, Spencer D. Shelton, Ralph J. DeBerardinis, Prashant Mishra
Publikováno v:
Science Advances. 9
Myopathies secondary to mitochondrial electron transport chain (ETC) dysfunction can result in devastating disease. While the consequences of ETC defects have been extensively studied in culture, little in vivo data are available. Using a mouse model
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a1eaf534f4464365d23b70aed02afd9
https://doi.org/10.1126/sciadv.add3216
https://doi.org/10.1126/sciadv.add3216
Autor:
Nicholas P Lesner, Xun Wang, Zhenkang Chen, Anderson Frank, Cameron J Menezes, Sara House, Spencer D Shelton, Andrew Lemoff, David G McFadden, Janaka Wansapura, Ralph J DeBerardinis, Prashant Mishra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bcf2dc2433a81ea5ccfc626aa09ce9cb
https://doi.org/10.7554/elife.80919.sa2
https://doi.org/10.7554/elife.80919.sa2
Autor:
Luiza Martins Nascentes Melo, Nicholas P. Lesner, Marie Sabatier, Jessalyn M. Ubellacker, Alpaslan Tasdogan
Publikováno v:
Trends in cancer. 8(12)
Metastasis is responsible for 90% of deaths in patients with cancer. Understanding the role of metabolism during metastasis has been limited by the development of robust and sensitive technologies that capture metabolic processes in metastasizing can
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa87b8f521c64d335e2b8313d8b0bdcd
https://pubmed.ncbi.nlm.nih.gov/35909026
https://pubmed.ncbi.nlm.nih.gov/35909026
Publikováno v:
Metabolic engineering
Pathogenic mutations in the mitochondrial genome (mtDNA) impair organellar ATP production, requiring mutant cells to activate metabolic adaptations for survival. Understanding how metabolism adapts to clinically relevant mtDNA mutations may provide i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd28c941b61df32bda6e234a181c2059
https://doi.org/10.1016/j.ymben.2020.03.010
https://doi.org/10.1016/j.ymben.2020.03.010
Autor:
Abhimanyu Garg, Wee-Teik Keng, Zhenkang Chen, Adwait Amod Sathe, Chao Xing, Pavithira Devi Kailasam, Yanqiu Shao, Nicholas P. Lesner, Claire B. Llamas, Anil K. Agarwal, Prashant Mishra
Publikováno v:
The Journal of clinical investigation. 132(23)
Multiple genetic loci have been reported for progeroid syndromes. However, the molecular defects in some extremely rare forms of progeria have yet to be elucidated. Here, we report a 21-year-old man of Chinese ancestry who has an autosomal recessive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad09711b9161c27770ef3230cfa90742
https://pubmed.ncbi.nlm.nih.gov/36282599
https://pubmed.ncbi.nlm.nih.gov/36282599