Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Nicholas P Kwiatkowski"'
Autor:
Mengyang Fan, Wenchao Lu, Jianwei Che, Nicholas P Kwiatkowski, Yang Gao, Hyuk-Soo Seo, Scott B Ficarro, Prafulla C Gokhale, Yao Liu, Ezekiel A Geffken, Jimit Lakhani, Kijun Song, Miljan Kuljanin, Wenzhi Ji, Jie Jiang, Zhixiang He, Jason Tse, Andrew S Boghossian, Matthew G Rees, Melissa M Ronan, Jennifer A Roth, Joseph D Mancias, Jarrod A Marto, Sirano Dhe-Paganon, Tinghu Zhang, Nathanael S Gray
Publikováno v:
eLife, Vol 11 (2022)
The transcription factor TEAD, together with its coactivator YAP/TAZ, is a key transcriptional modulator of the Hippo pathway. Activation of TEAD transcription by YAP has been implicated in a number of malignancies, and this complex represents a prom
Externí odkaz:
https://doaj.org/article/885c81e0f1964e4e986cf2271d9a8b62
Autor:
Mei Zeng, Nicholas P Kwiatkowski, Tinghu Zhang, Behnam Nabet, Mousheng Xu, Yanke Liang, Chunshan Quan, Jinhua Wang, Mingfeng Hao, Sangeetha Palakurthi, Shan Zhou, Qing Zeng, Paul T Kirschmeier, Khyati Meghani, Alan L Leggett, Jun Qi, Geoffrey I Shapiro, Joyce F Liu, Ursula A Matulonis, Charles Y Lin, Panagiotis A Konstantinopoulos, Nathanael S Gray
Publikováno v:
eLife, Vol 7 (2018)
High-grade serous ovarian cancer is characterized by extensive copy number alterations, among which the amplification of MYC oncogene occurs in nearly half of tumors. We demonstrate that ovarian cancer cells highly depend on MYC for maintaining their
Externí odkaz:
https://doaj.org/article/28fdc67b84ee4b348cb7df68b272d1b0
Autor:
Ingeborg Menzl, Tinghu Zhang, Angelika Berger-Becvar, Reinhard Grausenburger, Gerwin Heller, Michaela Prchal-Murphy, Leo Edlinger, Vanessa M. Knab, Iris Z. Uras, Eva Grundschober, Karin Bauer, Mareike Roth, Anna Skucha, Yao Liu, John M. Hatcher, Yanke Liang, Nicholas P. Kwiatkowski, Daniela Fux, Andrea Hoelbl-Kovacic, Stefan Kubicek, Junia V. Melo, Peter Valent, Thomas Weichhart, Florian Grebien, Johannes Zuber, Nathanael S. Gray, Veronika Sexl
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Cyclin-dependent kinases are deregulated in blood cancers. Here, the authors show that CDK8, independent of its kinase activity, regulates mTOR signalling for the maintenance of BCR-ABL1+ leukemia, and that the dual inhibition of CDK8 and mTOR signal
Externí odkaz:
https://doaj.org/article/90ab601100a74a6da15edcbbea0a9c4e
Autor:
Ricardo de Matos Simoes, Ryosuke Shirasaki, Sondra L. Downey-Kopyscinski, Geoffrey M. Matthews, Benjamin G. Barwick, Vikas A. Gupta, Daphné Dupéré-Richer, Shizuka Yamano, Yiguo Hu, Michal Sheffer, Eugen Dhimolea, Olga Dashevsky, Sara Gandolfi, Kazuya Ishiguro, Robin M. Meyers, Jordan G. Bryan, Neekesh V. Dharia, Paul J. Hengeveld, Johanna B. Brüggenthies, Huihui Tang, Andrew J. Aguirre, Quinlan L. Sievers, Benjamin L. Ebert, Brian J. Glassner, Christopher J. Ott, James E. Bradner, Nicholas P. Kwiatkowski, Daniel Auclair, Joan Levy, Jonathan J. Keats, Richard W. J. Groen, Nathanael S. Gray, Aedin C. Culhane, James M. McFarland, Joshua M. Dempster, Jonathan D. Licht, Lawrence H. Boise, William C. Hahn, Francisca Vazquez, Aviad Tsherniak, Constantine S. Mitsiades
Publikováno v:
de Matos Simoes, R, Shirasaki, R, Downey-Kopyscinski, S L, Matthews, G M, Barwick, B G, Gupta, V A, Dupéré-Richer, D, Yamano, S, Hu, Y, Sheffer, M, Dhimolea, E, Dashevsky, O, Gandolfi, S, Ishiguro, K, Meyers, R M, Bryan, J G, Dharia, N V, Hengeveld, P J, Brüggenthies, J B, Tang, H, Aguirre, A J, Sievers, Q L, Ebert, B L, Glassner, B J, Ott, C J, Bradner, J E, Kwiatkowski, N P, Auclair, D, Levy, J, Keats, J J, Groen, R W J, Gray, N S, Culhane, A C, McFarland, J M, Dempster, J M, Licht, J D, Boise, L H, Hahn, W C, Vazquez, F, Tsherniak, A & Mitsiades, C S 2023, ' Genome-scale functional genomics identify genes preferentially essential for multiple myeloma cells compared to other neoplasias ', Nature Cancer, vol. 4, no. 5, pp. 754-773 . https://doi.org/10.1038/s43018-023-00550-x
Nature Cancer, 4(5), 754-773. Nature Research
Nature Cancer, 4(5), 754-773. Nature Research
Clinical progress in multiple myeloma (MM), an incurable plasma cell (PC) neoplasia, has been driven by therapies that have limited applications beyond MM/PC neoplasias and do not target specific oncogenic mutations in MM. Instead, these agents targe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c38520e5128234e34753590416d0e64
https://doi.org/10.1038/s43018-023-00550-x
https://doi.org/10.1038/s43018-023-00550-x
Autor:
Yang Gao, Baishan Jiang, Hellen Kim, Matthew J. Berberich, Jianwei Che, Katherine A. Donovan, John M. Hatcher, Fidel Huerta, Nicholas P. Kwiatkowski, Yingpeng Liu, Peter P. Liuni, Rebecca J. Metivier, Vineeth K. Murali, Radosław P. Nowak, Tinghu Zhang, Eric S. Fischer, Nathanael S. Gray, Lyn H. Jones
Publikováno v:
Journal of Medicinal Chemistry. 66:5524-5535
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::52ba941eed228f45c1fa29dc3785c8d3
https://doi.org/10.1021/acs.jmedchem.2c01864
https://doi.org/10.1021/acs.jmedchem.2c01864
Autor:
Monica J. Bohmer, Jinhua Wang, Eva S. Istvan, Madeline R. Luth, Jennifer E. Collins, Edward L. Huttlin, Lushun Wang, Nimisha Mittal, Mingfeng Hao, Nicholas P. Kwiatkowski, Steven P. Gygi, Ratna Chakrabarti, Xianming Deng, Daniel E. Goldberg, Elizabeth A. Winzeler, Nathanael S. Gray, Debopam Chakrabarti
Publikováno v:
ACS Infectious Diseases. 9:1004-1021
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6d1095be44db8cc485df1077fb5d3391
https://doi.org/10.1021/acsinfecdis.3c00025
https://doi.org/10.1021/acsinfecdis.3c00025
Autor:
Pasi A. Jänne, Nathanael S. Gray, Michael J. Eck, Michael D. Cameron, Prafulla C. Gokhale, Man Xu, Stephen Wang, Michael J. Poitras, Pinar Ö. Eser, Nicholas P. Kwiatkowski, John M. Hatcher, Mika Lin, Alyssa Verano, Heidi M. Haikala, Yoonji Eum, Tyler S. Beyett, Jaebong Jang, Jieun Son
Supplementary Data from A Novel HER2-Selective Kinase Inhibitor Is Effective in HER2 Mutant and Amplified Non–Small Cell Lung Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fa51d44206e743a06a491f4c4226891
https://doi.org/10.1158/0008-5472.22431270
https://doi.org/10.1158/0008-5472.22431270
Autor:
Pasi A. Jänne, Nathanael S. Gray, Michael J. Eck, Michael D. Cameron, Prafulla C. Gokhale, Man Xu, Stephen Wang, Michael J. Poitras, Pinar Ö. Eser, Nicholas P. Kwiatkowski, John M. Hatcher, Mika Lin, Alyssa Verano, Heidi M. Haikala, Yoonji Eum, Tyler S. Beyett, Jaebong Jang, Jieun Son
In-frame insertions in exon 20 of HER2 are the most common HER2 mutations in patients with non–small cell lung cancer (NSCLC), a disease in which approved EGFR/HER2 tyrosine kinase inhibitors (TKI) display poor efficiency and undesirable side effec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::97a8ef884fce9cee6f7c5310978d793e
https://doi.org/10.1158/0008-5472.c.6513855.v1
https://doi.org/10.1158/0008-5472.c.6513855.v1
Autor:
Nathanael S. Gray, David M. Sabatini, Kwok-Kin Wong, Pasi A. Janne, Stephen J. Elledge, Danny M. Chou, Kathryn D. Held, Hidemasa Kawamura, Abigail Altabef, Tanya Tupper, Yuchuan Wang, Matthew P. Patricelli, Seong A. Kang, Carson C. Thoreen, Mario Niepel, Dalia Ercan, Peng Gao, Kenneth D. Westover, Jinhua Wang, Nicholas P. Kwiatkowski, Yan Liu, Wooyoung Hur, Xin Zhang, Sivapriya Kirubakaran, Chunxiao Xu, Qingsong Liu
PDF file - 719K, Supplemental figure 1. Torin2 on PC-3 wide type cell line, the IB was made after 30 min treatment of drug at indicated concentrations. Supplemental figure 2. Torin1, Torin2, AZD8055 and BEZ235 on HeLa and HCT-116 cell line at differe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02f1b766942775ec1d341f6520972504
https://doi.org/10.1158/0008-5472.22398726.v1
https://doi.org/10.1158/0008-5472.22398726.v1
Autor:
Nathanael S. Gray, David M. Sabatini, Kwok-Kin Wong, Pasi A. Janne, Stephen J. Elledge, Danny M. Chou, Kathryn D. Held, Hidemasa Kawamura, Abigail Altabef, Tanya Tupper, Yuchuan Wang, Matthew P. Patricelli, Seong A. Kang, Carson C. Thoreen, Mario Niepel, Dalia Ercan, Peng Gao, Kenneth D. Westover, Jinhua Wang, Nicholas P. Kwiatkowski, Yan Liu, Wooyoung Hur, Xin Zhang, Sivapriya Kirubakaran, Chunxiao Xu, Qingsong Liu
PDF file - 401K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cfd6389bcfe5cc37d8e136047ce9803
https://doi.org/10.1158/0008-5472.22398723.v1
https://doi.org/10.1158/0008-5472.22398723.v1