Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Nicholas P J Brindle"'
Autor:
Neil Bate, Christos G Savva, Peter C E Moody, Edward A Brown, Sian E Evans, Jonathan K Ball, John W R Schwabe, Julian E Sale, Nicholas P J Brindle
Publikováno v:
PLoS Pathogens, Vol 18, Iss 7, p e1010733 (2022)
Emerging SARS-CoV-2 variants are creating major challenges in the ongoing COVID-19 pandemic. Being able to predict mutations that could arise in SARS-CoV-2 leading to increased transmissibility or immune evasion would be extremely valuable in develop
Externí odkaz:
https://doaj.org/article/1c450b5c20754a42910056edeab3abf1
Publikováno v:
PLoS ONE, Vol 7, Iss 1, p e29319 (2012)
Angiopoietin-1 (Ang1) signals via the receptor tyrosine kinase Tie2 which exists in complex with the related protein Tie1 at the endothelial cell surface. Tie1 undergoes regulated ectodomain cleavage in response to phorbol esters, vascular endothelia
Externí odkaz:
https://doaj.org/article/a1ccefb4f8ea49b2bbd6f0370f6a2544
Autor:
Nicholas P J Brindle
Publikováno v:
Eye. 9:167-172
Following transplantation endothelial cells lining an allograft come into contact with immune cells of the recipient. Activation of an immune response, by graft endothelial or other cells, will lead to local increases in cytokine production and cell-
Autor:
Nicholas P. J. Brindle
Publikováno v:
Cardiovascular Research. 27:1162-1172
Publikováno v:
Biochemical Journal. 280:99-104
The role of insulin in the regulation of plasma triacylglycerol is poorly understood. Conflicting actions of insulin on rat liver cells have been reported, insulin inhibiting triacylglycerol secretion in short incubations (less than 24 h) and stimula
Publikováno v:
International journal of oncology. 31(4)
The receptor tyrosine kinase Tie1 is expressed primarily in vascular endothelial cells. The receptor has also been detected in epithelial tumours in breast, thyroid and gastric cancers and in tumour cell lines where it appears as a 45 kDa truncated r
1. We studied the effect of two structurally-related, selective inhibitors of protein kinase C, Ro 31-8220 and Ro 31-7549, on the reinitiation of proliferation in quiescent first passage rabbit aortic smooth muscle cells in response to (a) the direct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::383c3e8368701439724469a9a3a98d84
https://europepmc.org/articles/PMC1510373/
https://europepmc.org/articles/PMC1510373/
Publikováno v:
Growth Factors and the Cardiovascular System ISBN: 9781461363545
Proliferation of vascular smooth muscle cells (VSMC) is a characteristic feature of repair following vascular injury and adaptation to increased intraluminal pressure such as occurs in arteriovenous fistulas and in pulmonary hypertension. The intimai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::630c29abd401f5da41c7c55608cb5faf
https://doi.org/10.1007/978-1-4615-3098-5_12
https://doi.org/10.1007/978-1-4615-3098-5_12
The effects of insulin and anti-(insulin receptor) monoclonal antibodies on tyrosine phosphorylation were investigated in fibroblasts transfected with human insulin receptor cDNA (NIH 3T3HIR3.5 cells) using anti-phosphotyrosine immunoblotting. Insuli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92fb1a8f7ed27e8774918e81edfd1e11
https://europepmc.org/articles/PMC1131483/
https://europepmc.org/articles/PMC1131483/
Publikováno v:
Biochemical Society Transactions. 26:S365-S365