Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Nicholas P Gauthier"'
Autor:
Elin Nyman, Richard R Stein, Xiaohong Jing, Weiqing Wang, Benjamin Marks, Ioannis K Zervantonakis, Anil Korkut, Nicholas P Gauthier, Chris Sander
Publikováno v:
PLoS Computational Biology, Vol 16, Iss 7, p e1007909 (2020)
Cancer cells have genetic alterations that often directly affect intracellular protein signaling processes allowing them to bypass control mechanisms for cell death, growth and division. Cancer drugs targeting these alterations often work initially,
Externí odkaz:
https://doaj.org/article/b2671e67147a44b588e191bac675364c
Autor:
Brenna Norton-Baker, Mackenzie C. R. Denton, Natasha P. Murphy, Benjamin Fram, Samuel Lim, Erika Erickson, Nicholas P. Gauthier, Gregg T. Beckham
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract As genomic databases expand and artificial intelligence tools advance, there is a growing demand for efficient characterization of large numbers of proteins. To this end, here we describe a generalizable pipeline for high-throughput protein
Externí odkaz:
https://doaj.org/article/663421856240400c9acd2223616ba2ec
Autor:
Benjamin Fram, Yang Su, Ian Truebridge, Adam J. Riesselman, John B. Ingraham, Alessandro Passera, Eve Napier, Nicole N. Thadani, Samuel Lim, Kristen Roberts, Gurleen Kaur, Michael A. Stiffler, Debora S. Marks, Christopher D. Bahl, Amir R. Khan, Chris Sander, Nicholas P. Gauthier
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract A major challenge in protein design is to augment existing functional proteins with multiple property enhancements. Altering several properties likely necessitates numerous primary sequence changes, and novel methods are needed to accurately
Externí odkaz:
https://doaj.org/article/a182732b5fb749998a8d6aa717746d50
Autor:
Evan J Molinelli, Anil Korkut, Weiqing Wang, Martin L Miller, Nicholas P Gauthier, Xiaohong Jing, Poorvi Kaushik, Qin He, Gordon Mills, David B Solit, Christine A Pratilas, Martin Weigt, Alfredo Braunstein, Andrea Pagnani, Riccardo Zecchina, Chris Sander
Publikováno v:
PLoS Computational Biology, Vol 9, Iss 12, p e1003290 (2013)
We present a powerful experimental-computational technology for inferring network models that predict the response of cells to perturbations, and that may be useful in the design of combinatorial therapy against cancer. The experiments are systematic
Externí odkaz:
https://doaj.org/article/b42abf9d37ee45299b42ecb7866bb94f
Autor:
Roc Reguant, Yevgeniy Antipin, Rob Sheridan, Christian Dallago, Drew Diamantoukos, Augustin Luna, Chris Sander, Nicholas Paul Gauthier
Publikováno v:
F1000Research, Vol 9 (2020)
AlignmentViewer is a web-based tool to view and analyze multiple sequence alignments of protein families. The particular strengths of AlignmentViewer include flexible visualization at different scales as well as analysis of conservation patterns and
Externí odkaz:
https://doaj.org/article/0b1f07fc91814428a93556b311023fdf
Autor:
Benjamin Fram, Ian Truebridge, Yang Su, Adam J. Riesselman, John B. Ingraham, Alessandro Passera, Eve Napier, Nicole N. Thadani, Samuel Lim, Kristen Roberts, Gurleen Kaur, Michael Stiffler, Debora S. Marks, Christopher D. Bahl, Amir R. Khan, Chris Sander, Nicholas P. Gauthier
Designing optimized proteins is important for a range of practical applications. Protein design is a rapidly developing field that would benefit from approaches that enable many changes in the amino acid primary sequence, rather than a small number o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c1122d941ed1ee89a4b27e1d88ee82c7
https://doi.org/10.1101/2023.05.09.539914
https://doi.org/10.1101/2023.05.09.539914
Autor:
Debora S. Marks, Nicholas P. Gauthier, Richard R. Stein, Sachdev S. Sidhu, Michael A Stiffler, Kelly P Brock, Joan Teyra, Frank J. Poelwijk, Adam J. Riesselman, Chris Sander
Publikováno v:
Cell systems. 10(1)
Summary Natural evolution encodes rich information about the structure and function of biomolecules in the genetic record. Previously, statistical analysis of co-variation patterns in natural protein families has enabled the accurate computation of 3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad3666d2d66407cf02c7b0e44f087ef6
https://pubmed.ncbi.nlm.nih.gov/31838147
https://pubmed.ncbi.nlm.nih.gov/31838147
Autor:
Chris Sander, Nicholas P. Gauthier, Joan Teyra, Kelly P Brock, Michael A Stiffler, Debora S. Marks, Frank J. Poelwijk, Richard R. Stein, Sachdev S. Sidhu
Natural evolution encodes rich information about the structure and function of biomolecules in the genetic record. Previously, statistical analysis of co-variation patterns in natural protein families has enabled the accurate computation of 3D struct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24d491b5facd8e146ce328ab05afc66b
https://doi.org/10.1101/667790
https://doi.org/10.1101/667790
Autor:
Weiqing Wang, Ioannis K. Zervantonakis, Xiaohong Jing, Elin Nyman, Benjamin Marks, Nicholas P. Gauthier, Richard R. Stein, Chris Sander, Anil Korkut
Publikováno v:
PLoS Computational Biology, Vol 16, Iss 7, p e1007909 (2020)
PLoS Computational Biology
PLoS Computational Biology
Cancer cells have genetic alterations that often directly affect intracellular protein signaling processes allowing them to bypass control mechanisms for cell death, growth and division. Cancer drugs targeting these alterations often work initially,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b88548b6d97c12d1e3f65d04c1267c38
https://doi.org/10.1101/568758
https://doi.org/10.1101/568758
Autor:
Rob Sheridan, Augustin Luna, Drew Diamantoukos, Chris Sander, Nicholas P. Gauthier, Yevgeniy Antipin, Roc Reguant, Christian Dallago
Publikováno v:
F1000Research
AlignmentViewer is a web-based tool to view and analyze multiple sequence alignments of protein families. The particular strengths of AlignmentViewer include flexible visualization at different scales as well as analysis of conservation patterns and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e8756193e8a4c2fc3b9fb415608f154
https://doi.org/10.12688/f1000research.22242.2
https://doi.org/10.12688/f1000research.22242.2