Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Nicholas P Blockley"'
Autor:
Jesús Molinar-Díaz, Andi Arjuna, Nichola Abrehart, Alison McLellan, Roy Harris, Md Towhidul Islam, Ahlam Alzaidi, Chris R. Bradley, Charlotte Gidman, Malcolm J. W. Prior, Jeremy Titman, Nicholas P. Blockley, Peter Harvey, Luca Marciani, Ifty Ahmed
Publikováno v:
Molecules, Vol 29, Iss 18, p 4296 (2024)
In this research, resorbable phosphate-based glass (PBG) compositions were developed using varying modifier oxides including iron (Fe2O3), copper (CuO), and manganese (MnO2), and then processed via a rapid single-stage flame spheroidisation process t
Externí odkaz:
https://doaj.org/article/546ea4a30ba348fcb47f1a9f7a04a58a
Autor:
Linh N. N. Le, Gregory J. Wheeler, Emily N. Holy, Corinne A. Donnay, Nicholas P. Blockley, Alan H. Yee, Kwan L. Ng, Audrey P. Fan
Publikováno v:
Frontiers in Physiology, Vol 14 (2023)
Introduction: We aimed to demonstrate non-invasive measurements of regional oxygen extraction fraction (OEF) from quantitative BOLD MRI modeling at baseline and after pharmacological vasodilation. We hypothesized that OEF decreases in response to vas
Externí odkaz:
https://doaj.org/article/c8286de59be542a5878058b87ffe90ea
Publikováno v:
Frontiers in Physiology, Vol 14 (2023)
Introduction: Cerebral blood flow (CBF) is an important physiological parameter that can be quantified non-invasively using arterial spin labelling (ASL) imaging. Although most ASL studies are based on single-timepoint strategies, multi-timepoint app
Externí odkaz:
https://doaj.org/article/4486597fdcf1445a83382e410ecb9eac
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
Externí odkaz:
https://doaj.org/article/739fc81c00f447268d92d2ac2812901e
Autor:
Sana Suri, Daniel Bulte, Scott T. Chiesa, Klaus P. Ebmeier, Peter Jezzard, Sebastian W. Rieger, Jemma E. Pitt, Ludovica Griffanti, Thomas W. Okell, Martin Craig, Michael A. Chappell, Nicholas P. Blockley, Mika Kivimäki, Archana Singh-Manoux, Ashraf W. Khir, Alun D. Hughes, John E. Deanfield, Daria E. A. Jensen, Sebastian F. Green, Veronika Sigutova, Michelle G. Jansen, Enikő Zsoldos, Clare E. Mackay
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
BackgroundIt is well-established that what is good for the heart is good for the brain. Vascular factors such as hypertension, diabetes, and high cholesterol, and genetic factors such as the apolipoprotein E4 allele increase the risk of developing bo
Externí odkaz:
https://doaj.org/article/fd6cdf6493f34421b7162fca5d4a66a0
Autor:
Yunus Msayib, George W. J. Harston, Kevin J. Ray, James R. Larkin, Brad A. Sutherland, Fintan Sheerin, Nicholas P. Blockley, Thomas W. Okell, Peter Jezzard, Andrew Baldwin, Nicola R. Sibson, James Kennedy, Michael A. Chappell
Purpose In chemical exchange saturation transfer imaging, saturation effects between − 2 to − 5 ppm (nuclear Overhauser effects, NOEs) have been shown to exhibit contrast in preclinical stroke models. Our previous work on NOEs in human stroke use
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46e4d428a55fd324d550fe81df8632b9
https://doi.org/10.1002/mrm.29187
https://doi.org/10.1002/mrm.29187
Publikováno v:
PLoS ONE, Vol 9, Iss 1 (2014)
Externí odkaz:
https://doaj.org/article/6b823e3c45e14a568a73e6e6f1623b5f
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e68122 (2013)
Functional MRI (fMRI) using the blood oxygenation level dependent (BOLD) signal is a common technique in the study of brain function. The BOLD signal is sensitive to the complex interaction of physiological changes including cerebral blood flow (CBF)
Externí odkaz:
https://doaj.org/article/fb08b98f854a452c8c7c4c9e29ab0987
Autor:
Nicholas P. Blockley, Alan J. Stone
Streamlined-qBOLD (sqBOLD) is a recently proposed refinement of the quantitative BOLD (qBOLD) technique capable of producing non-invasive and quantitative maps of oxygen extraction fraction (OEF) in a clinically feasible scan time. However, sqBOLD me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2f7ff6c5123bc1b62a046cc3f690b763
https://doi.org/10.1101/2020.06.14.151134
https://doi.org/10.1101/2020.06.14.151134
Autor:
Michael A. Chappell, Alexander Seiler, Ulrike Nöth, Marlies Wagner, Oliver C. Singer, Johannes C. Klein, Ralf Deichmann, Nicholas P. Blockley
Publikováno v:
Journal of Cerebral Blood Flow & Metabolism. 39:454-465
Oxygenation-sensitive spin relaxation time T2′ and relaxation rate R2′ (1/T2′) are presumed to be markers of the cerebral oxygen extraction fraction (OEF) in acute ischemic stroke. In this study, we investigate the relationship of T2′/R2′ w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce971b0803f9c90c1096332ddbcd8beb
https://doi.org/10.1177/0271678x17732448
https://doi.org/10.1177/0271678x17732448