Zobrazeno 1 - 10
of 359
pro vyhledávání: '"Nicholas P, West"'
Autor:
XinYue Wang, William J. Jowsey, Chen-Yi Cheung, Caitlan J. Smart, Hannah R. Klaus, Noon EJ Seeto, Natalie JE Waller, Michael T. Chrisp, Amanda L. Peterson, Boatema Ofori-Anyinam, Emily Strong, Brunda Nijagal, Nicholas P. West, Jason H. Yang, Peter C. Fineran, Gregory M. Cook, Simon A. Jackson, Matthew B. McNeil
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Drug-resistant strains of Mycobacterium tuberculosis are a major global health problem. Resistance to the front-line antibiotic isoniazid is often associated with mutations in the katG-encoded bifunctional catalase-peroxidase. We hypothesise
Externí odkaz:
https://doaj.org/article/138d2c76fe9b40538e5e763113a839ee
Autor:
Kanishta Srihar, Arief Gusnanto, Susan D. Richman, Nicholas P. West, Leanne Galvin, Daniel Bottomley, Gemma Hemmings, Amy Glover, Subaashini Natarajan, Rebecca Miller, Sameira Arif, Hannah Rossington, Thomas L. Dunwell, Simon C. Dailey, Gracielle Fontarum, Agnes George, Winnie Wu, Phil Quirke, Henry M. Wood
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-9 (2024)
Abstract Microsatellite instability (MSI) occurs across a number of cancers and is associated with different clinical characteristics when compared to microsatellite stable (MSS) cancers. As MSI cancers have different characteristics, routine MSI tes
Externí odkaz:
https://doaj.org/article/a79db419a61e40a695fcb42742c491c4
Autor:
Krishanth Naidu, Pierre H. Chapuis, Charles Chan, Matthew J.F.X Rickard, Nicholas P. West, David G. Jayne, Kheng-Seong Ng
Publikováno v:
World Journal of Surgical Oncology, Vol 22, Iss 1, Pp 1-11 (2024)
Abstract Background Ex vivo tissue morphometric (TM) measurements have been proposed as a quality marker for colorectal cancer (CRC) surgery. However, their survival associations require clarification. This study aimed to evaluate the feasibility of
Externí odkaz:
https://doaj.org/article/4b94ab27d2f6400ea7f1cb87765151c9
Autor:
Cheng-Yu Chiang, Nicholas P. West
Publikováno v:
PeerJ, Vol 12, p e18404 (2024)
Tuberculosis (TB) caused by Mycobacterium tuberculosis has been a threat to human health for thousands of years and still leads to millions of deaths each year. TB is a disease that is refractory to treatment, partially due to its capacity for in-hos
Externí odkaz:
https://doaj.org/article/51c7e70802a24fe192981ea90620fed7
Autor:
Marco Gustav, Nic Gabriel Reitsam, Zunamys I. Carrero, Chiara M. L. Loeffler, Marko van Treeck, Tanwei Yuan, Nicholas P. West, Philip Quirke, Titus J. Brinker, Hermann Brenner, Loëtitia Favre, Bruno Märkl, Albrecht Stenzinger, Alexander Brobeil, Michael Hoffmeister, Julien Calderaro, Anaïs Pujals, Jakob Nikolas Kather
Publikováno v:
npj Precision Oncology, Vol 8, Iss 1, Pp 1-11 (2024)
Abstract In the spectrum of colorectal tumors, microsatellite-stable (MSS) tumors with DNA polymerase ε (POLE) mutations exhibit a hypermutated profile, holding the potential to respond to immunotherapy similarly to their microsatellite-instable (MS
Externí odkaz:
https://doaj.org/article/43aa367ce4a841f587e2ab532d5c55a4
Autor:
Philip A Wheeler, Nicholas S West, Richard Powis, Rhydian Maggs, Michael Chu, Rachel A Pearson, Nick Willis, Bartlomiej Kurec, Katie L. Reed, David G. Lewis, John Staffurth, Emiliano Spezi, Anthony E. Millin
Publikováno v:
Radiation Oncology, Vol 19, Iss 1, Pp 1-11 (2024)
Abstract Background Current automated planning solutions are calibrated using trial and error or machine learning on historical datasets. Neither method allows for the intuitive exploration of differing trade-off options during calibration, which may
Externí odkaz:
https://doaj.org/article/e896d6b30ee2484b927251cdf6a63ef2
Autor:
Kyle M. Hatton-Jones, Nicholas P. West, Mike W.C. Thang, Pin-Yen Chen, Peter Davoren, Allan W. Cripps, Amanda J. Cox
Publikováno v:
Journal of Obesity & Metabolic Syndrome, Vol 33, Iss 1, Pp 64-75 (2024)
Background : The contributions of the gut microbiota to obesity and metabolic disease represent a potentially modifiable factor that may explain variation in risk between individuals. This study aimed to explore relationships among microbial composit
Externí odkaz:
https://doaj.org/article/907c6fde88ad4c48a8ea515c0b523831
Autor:
Matthias Görges, Jonath Sujan, Nicholas C West, Rama Syamala Sreepada, Michael D Wood, Beth A Payne, Swati Shetty, Jean P Gelinas, Ainsley M Sutherland
Publikováno v:
JMIR Perioperative Medicine, Vol 7, p e54926 (2024)
BackgroundExposure to opioids after surgery is the initial contact for some people who develop chronic opioid use disorder. Hence, effective postoperative pain management, with less reliance on opioids, is critical. The Perioperative Opioid Quality I
Externí odkaz:
https://doaj.org/article/80818d57220741fe99a82d9e0e75eb8e
Autor:
Anne B Chang, Keith Grimwood, Katherine J Baines, Gabrielle B McCallum, Peter S Morris, Paul J Torzillo, Andre Schultz, Stephanie T Yerkovich, Steven McPhail, Nicholas P West, Vikas Goyal, Julie M Marchant, Robyn L Marsh, Anita Champion, Lucy C Morgan, Lucy Burr, Lesley Versteegh, Mark D Chatfield, Hannah O’Farrell, Kah P Eg, Margaret McElrea, Anne M Nathan, Marion O Sanchez, Marianne Parsons
Publikováno v:
BMJ Open Respiratory Research, Vol 11, Iss 1 (2024)
Introduction Bronchiectasis is a worldwide chronic lung disorder where exacerbations are common. It affects people of all ages, but especially Indigenous populations in high-income nations. Despite being a major contributor to chronic lung disease, t
Externí odkaz:
https://doaj.org/article/a299fd5277874a52a2cbd66cfaa46866
Autor:
Miljan Stupar, Lendl Tan, Edward D. Kerr, Christopher J. De Voss, Brian M. Forde, Benjamin L. Schulz, Nicholas P. West
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract The ability of Mycobacterium tuberculosis (Mtb) to persist in the host complicates and prolongs tuberculosis (TB) patient chemotherapy. Here we demonstrate that a neglected two-component system (TCS) of Mtb, TcrXY, is an autoregulated acid-s
Externí odkaz:
https://doaj.org/article/54acaefe3dc54bb8a1d52f6454f667e1