Zobrazeno 1 - 10
of 108
pro vyhledávání: '"Nicholas P, Tobin"'
Autor:
Pedro Fonseca, Weiyingqi Cui, Nona Struyf, Le Tong, Ayushi Chaurasiya, Felipe Casagrande, Honglei Zhao, Dinura Fernando, Xinsong Chen, Nicholas P. Tobin, Brinton Seashore-Ludlow, Andreas Lundqvist, Johan Hartman, Anita Göndör, Päivi Östling, Lars Holmgren
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 43, Iss 1, Pp 1-23 (2024)
Abstract Background Tumor cells have the ability to invade and form small clusters that protrude into adjacent tissues, a phenomenon that is frequently observed at the periphery of a tumor as it expands into healthy tissues. The presence of these clu
Externí odkaz:
https://doaj.org/article/33dfb61ce30b4942b583460a044384b6
Autor:
Miguel Castresana-Aguirre, Annelie Johansson, Alexios Matikas, Theodoros Foukakis, Linda S. Lindström, Nicholas P. Tobin
Publikováno v:
Breast Cancer Research, Vol 26, Iss 1, Pp 1-11 (2024)
Abstract Background The clinical utility of gene signatures in older breast cancer patients remains unclear. We aimed to determine signature prognostic capacity in this patient subgroup. Methods Research versions of the genomic grade index (GGI), 70-
Externí odkaz:
https://doaj.org/article/7787a17cbd274b328d037a1979a3c874
Autor:
Le Tong, Veronika Kremer, Shi Yong Neo, Yaxuan Liu, Yi Chen, Arnika Kathleen Wagner, Ying Yang, Ziqing Chen, Christina Seitz, Nicholas Patrick Tobin, Maarten Alexander Ligtenberg, Evren Alici, Xinsong Chen, Felix Haglund, Barbara Seliger, Ulrika Harmenberg, Eugenia Colón, Ann‐Helén Scherman Plogell, Lisa Lei Liu, Andreas Lundqvist
Publikováno v:
Cancer Communications, Vol 43, Iss 7, Pp 855-859 (2023)
Externí odkaz:
https://doaj.org/article/f754139632394b4abbaab496545dde86
Publikováno v:
npj Precision Oncology, Vol 6, Iss 1, Pp 1-10 (2022)
Abstract Genomic alterations resulting in loss of control over the cell cycle is a fundamental hallmark of human malignancies. Whilst pan-cancer studies have broadly assessed tumour genomics and their impact on oncogenic pathways, analyses taking the
Externí odkaz:
https://doaj.org/article/9751e728fcc047beaf2952563a1b6249
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 3, p e1010020 (2022)
High throughput biology enables the measurements of relative concentrations of thousands of biomolecules from e.g. tissue samples. The process leaves the investigator with the problem of how to best interpret the potentially large number of differenc
Externí odkaz:
https://doaj.org/article/737ad51f27f344649ab07554f7c763dd
Autor:
Ioannis Zerdes, Emmanouil G. Sifakis, Alexios Matikas, Sebastian Chrétien, Nicholas P. Tobin, Johan Hartman, George Z. Rassidakis, Jonas Bergh, Theodoros Foukakis
Publikováno v:
Molecular Oncology, Vol 14, Iss 5, Pp 951-963 (2020)
Gene and protein expression of programmed death‐ligand 1 (PD‐L1) are prognostic in early breast cancer (BC), but their prognostic information is inconsistent at least in some biological subgroups. The validated prognostic gene signatures (GS) in
Externí odkaz:
https://doaj.org/article/35cba073e6ea4fa1bf36cbaeb5a2366b
Autor:
Jessica Svedlund, Carina Strell, Xiaoyan Qian, Kilian J.C. Zilkens, Nicholas P. Tobin, Jonas Bergh, Anieta M. Sieuwerts, Mats Nilsson
Publikováno v:
EBioMedicine, Vol 48, Iss , Pp 212-223 (2019)
Background: Gene expression analysis of breast cancer largely relies on homogenized tissue samples. Due to the high degree of cellular and molecular heterogeneity of tumor tissues, bulk tissue-based analytical approaches can only provide very limited
Externí odkaz:
https://doaj.org/article/f5f93d401bf2454087abbe0b8a1391c0
Autor:
Annelie, Johansson, Huma, Dar, Laura J, van 't Veer, Nicholas P, Tobin, Gizeh, Perez-Tenorio, Anna, Nordenskjöld, Ulla, Johansson, Johan, Hartman, Lambert, Skoog, Christina, Yau, Christopher C, Benz, Laura J, Esserman, Olle, Stål, Bo, Nordenskjöld, Tommy, Fornander, Linda S, Lindström
Publikováno v:
Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 40(35)
To assess the long-term (20-year) endocrine therapy benefit in premenopausal patients with breast cancer.Secondary analysis of the Stockholm trial (STO-5, 1990-1997) randomly assigning 924 premenopausal patients to 2 years of goserelin (3.6 mg subcut
Autor:
Mohammad A. Alzubi, Tia H. Turner, Amy L. Olex, Sahib S. Sohal, Nicholas P. Tobin, Susana G. Recio, Jonas Bergh, Thomas Hatschek, Joel S. Parker, Carol A. Sartorius, Charles M. Perou, Mikhail G. Dozmorov, J. Chuck Harrell
Publikováno v:
Breast Cancer Research, Vol 21, Iss 1, Pp 1-15 (2019)
Abstract Background The seed and soil hypothesis was proposed over a century ago to describe why cancer cells (seeds) grow in certain organs (soil). Since then, the genetic properties that define the cancer cells have been heavily investigated; howev
Externí odkaz:
https://doaj.org/article/4c6513371deb4dd18f222731bbba6ee5
Autor:
Arian Lundberg, Linda S. Lindström, Jingmei Li, J. Chuck Harrell, Eva Darai-Ramqvist, Emmanouil G. Sifakis, Theodoros Foukakis, Charles M. Perou, Kamila Czene, Jonas Bergh, Nicholas P. Tobin
Publikováno v:
Breast Cancer Research, Vol 21, Iss 1, Pp 1-10 (2019)
Abstract Background Use of cyclin D1 (CCND1) gene amplification as a breast cancer biomarker has been hampered by conflicting assessments of the relationship between cyclin D1 protein levels and patient survival. Here, we aimed to clarify its prognos
Externí odkaz:
https://doaj.org/article/8be3793f16a749efa5f0ae8a141a5f09