Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Nicholas O. Stevers"'
Autor:
Takahide Nejo, Lin Wang, Kevin K. Leung, Albert Wang, Senthilnath Lakshmanachetty, Marco Gallus, Darwin W. Kwok, Chibo Hong, Lee H. Chen, Diego A. Carrera, Michael Y. Zhang, Nicholas O. Stevers, Gabriella C. Maldonado, Akane Yamamichi, Payal B. Watchmaker, Akul Naik, Anny Shai, Joanna J. Phillips, Susan M. Chang, Arun P. Wiita, James A. Wells, Joseph F. Costello, Aaron A. Diaz, Hideho Okada
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-17 (2024)
Abstract Despite advancements in cancer immunotherapy, solid tumors remain formidable challenges. In glioma, profound inter- and intra-tumoral heterogeneity of antigen landscape hampers therapeutic development. Therefore, it is critical to consider a
Externí odkaz:
https://doaj.org/article/4c9ca26f096d46feb278b4dfc8e66f04
Autor:
Hongwei Chen, Alfred E. Chang, Hayley J. Paholak, Nicholas O. Stevers, Kanokwan Sansanaphongpricha, Qiao Li, Joseph Burnett, Duxin Sun, Xin Luan, Miao He
Publikováno v:
Nanomedicine (Lond)
Aim: We aim to demonstrate that a local nanoparticle-mediated hyperthermia can effectively eliminate tumor-associated Tregs and thereby boost checkpoint blockade-based immunotherapy. Materials & methods: Photothermal therapy (PTT), mediated with syst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::239f9449d63c602adc08daf8e4ba3175
https://doi.org/10.2217/nnm-2019-0190
https://doi.org/10.2217/nnm-2019-0190
Autor:
Christina Leann Appin, Abigail K. Suwala, Stephanie Hilz, Radhika Mathur, Ivan V. Smirnov, Chibo Hong, Nicholas O. Stevers, Anny Shai, Albert Wang, Mitchel S. Berger, Susan M. Chang, Joanna J. Phillips, Joseph F. Costello
Publikováno v:
Cancer Research. 82:3797-3797
TERT promoter mutation (TPM) is found in over 80% of IDH-wildtype glioblastomas (GBMs) and IDH-mutant oligodendrogliomas (ODs). As TPM-mediated reactivation of telomerase is tumor specific, TPM- tumor cells could be selectively targeted to reverse tu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9f5e648db4dde0988cb2c0493e148f32
https://doi.org/10.1158/1538-7445.am2022-3797
https://doi.org/10.1158/1538-7445.am2022-3797
Autor:
Nicholas O. Stevers, Carter Barger, Olivia Lenzo, Chibo Hong, Katarzyna Soczek, Samuel H. Wu, Andrew M. McKinney, Abigail Suwala, Jennifer A. Doudna, Joseph F. Costello
Publikováno v:
Cancer Research. 82:2302-2302
Ninety percent of human tumors reactivate telomerase reverse transcriptase (TERT) to achieve cellular immortality. The route to immortality found in over 50 cancer types is mutation of the TERT promoter (TERTp) mutations. Studies in glioblastoma have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::847a8162b5d27efd587e841f72afe947
https://doi.org/10.1158/1538-7445.am2022-2302
https://doi.org/10.1158/1538-7445.am2022-2302
Autor:
Hongwei Chen, Ryan M. Clauson, Guoping Wang, Jinhui Liao, Chun Tao, Ashley Sough, Bing Liu, Duxin Sun, Ila Moncion, Sangyeul Hwang, Kanokwan Sansanaphongpricha, Nicholas O. Stevers, Hayley J. Paholak, Xin Luan, Hongxiang Hu
Publikováno v:
ACS applied materialsinterfaces. 11(27)
Although the functionalization of magnetic nanoparticles (MNPs) with biomolecules has been widely explored for various biological applications, achieving efficient bioconjugations with a wide range of biomolecules through a single, universal, and ver
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98e67564ea666ad93a523e58a5fc721c
https://pubmed.ncbi.nlm.nih.gov/31245984
https://pubmed.ncbi.nlm.nih.gov/31245984
Autor:
Duxin Sun, Hasan Korkaya, Nicholas O. Stevers, Hongwei Chen, Qiao Li, Miao He, Hayley J. Paholak, Joseph Burnett, Yadwinder S. Deol, Shawn G. Clouthier, Sean P. McDermott, Max S. Wicha, Tahra Luther
Publikováno v:
Biomaterials. 104:145-157
Increasing evidence suggesting breast cancer stem cells (BCSCs) drive metastasis and evade traditional therapies underscores a critical need to exploit the untapped potential of nanotechnology to develop innovative therapies that will significantly i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f14c79f19b05d2c731305f5688645846
https://doi.org/10.1016/j.biomaterials.2016.06.045
https://doi.org/10.1016/j.biomaterials.2016.06.045
Autor:
Nicholas O. Stevers, Ramdane Harouaka, Chang-Ching Lin, Hui Jiang, Mari Gasparyan, Miao-Chia Lo, Max S. Wicha, Samantha L. Tinsley, Duxin Sun, Rebecca Moody
Publikováno v:
Cancer Letters. 480:51
Triple-negative breast cancer (TNBC) is the most difficult subtype of breast cancer to treat due to a paucity of effective targeted therapies. Many studies have reported that breast cancer stem cells (BCSCs) are enriched in TNBC and are responsible f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::505ab11ecb646fe5019cb9fa2d98bd2d
https://doi.org/10.1016/j.canlet.2020.01.013
https://doi.org/10.1016/j.canlet.2020.01.013
Autor:
Ramdane Harouaka, Rebecca Moody, Nicholas O. Stevers, Miao-Chia Lo, Hui Jiang, Samantha L. Tinsley, Duxin Sun, Chang-Ching Lin, Max S. Wicha, Mari Gasparyan
Publikováno v:
Cancer letters. 438
Triple-negative breast cancer (TNBC) is the most difficult subtype of breast cancer to treat due to a paucity of effective targeted therapies. Many studies have reported that breast cancer stem cells (BCSCs) are enriched in TNBC and are responsible f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4af1f16c9212332fa05b260a63c81b92
https://pubmed.ncbi.nlm.nih.gov/32229161
https://pubmed.ncbi.nlm.nih.gov/32229161
Autor:
Nicholas O. Stevers, Samantha L. Tinsley, Chang-Ching Lin, Duxin Sun, Miao-Chia Lo, Rebecca Moody
Publikováno v:
Oncology Reports.
Targeting cancer stem cells (CSCs) is a key strategy to prevent cancers from developing drug resistance and metastasis. Mitochondria have been reported to be a vulnerability of CSCs by multiple studies. Here, we report that doxycycline, functioning a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53dac9b43c0ba6d9e224213ce60b7d6d
https://doi.org/10.3892/or.2018.6337
https://doi.org/10.3892/or.2018.6337
Autor:
Nicholas O. Stevers, Miao Chia Lo, Chang-Ching Lin, Jeanne A. Stuckey, Samantha L. Tinsley, Aleksas Matvekas, Duxin Sun, Jennifer L. Meagher, Rebecca Moody, Inkyung Jung
Publikováno v:
The Journal of biological chemistry. 293(6)
The transcription factor BCL11A has recently been reported to be a driving force in triple-negative breast cancer (TNBC), contributing to the maintenance of a chemoresistant breast cancer stem cell (BCSC) population. Although BCL11A was shown to supp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b72a6479fc9414cc0c53cd9f2324cce
https://pubmed.ncbi.nlm.nih.gov/29263092
https://pubmed.ncbi.nlm.nih.gov/29263092