Zobrazeno 1 - 10
of 86
pro vyhledávání: '"Nicholas O, Fischer"'
Autor:
Mariam Mohagheghi, Abisola Abisoye-Ogunniyan, Angela C. Evans, Alexander E. Peterson, Gregory A. Bude, Steven Hoang-Phou, Byron Dillon Vannest, Dominique Hall, Amy Rasley, Dina R. Weilhammer, Nicholas O. Fischer, Wei He, Beverly V. Robinson, Sukumar Pal, Anatoli Slepenkin, Luis de la Maza, Matthew A. Coleman
Publikováno v:
Vaccines, Vol 12, Iss 11, p 1246 (2024)
Background: Vaccine development against Chlamydia, a prevalent sexually transmitted infection (STI), is imperative due to its global public health impact. However, significant challenges arise in the production of effective subunit vaccines based on
Externí odkaz:
https://doaj.org/article/8a73fe6443b6407f917f96d9f4d91582
Autor:
Doris Lam, Heather A. Enright, Jose Cadena, Vivek Kurien George, David A. Soscia, Angela C. Tooker, Michael Triplett, Sandra K. G. Peters, Piyush Karande, Alexander Ladd, Chandrakumar Bogguri, Elizabeth K. Wheeler, Nicholas O. Fischer
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 17 (2023)
Externí odkaz:
https://doaj.org/article/46bf1bf290a6473294bc10f5300da66c
Autor:
Doris Lam, Heather A. Enright, Jose Cadena, Vivek Kurien George, David A. Soscia, Angela C. Tooker, Michael Triplett, Sandra K. G. Peters, Piyush Karande, Alexander Ladd, Chandrakumar Bogguri, Elizabeth K. Wheeler, Nicholas O. Fischer
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 17 (2023)
While there is a growing appreciation of three-dimensional (3D) neural tissues (i.e., hydrogel-based, organoids, and spheroids), shown to improve cellular health and network activity to mirror brain-like activity in vivo, functional assessment using
Externí odkaz:
https://doaj.org/article/3d854a25be3a4aa590525715e4cbe6c1
Autor:
Nicholas D. Henkel, Marissa A. Smail, Xiaojun Wu, Heather A. Enright, Nicholas O. Fischer, Hunter M. Eby, Robert E. McCullumsmith, Rammohan Shukla
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract Animal models have expanded our understanding of temporal lobe epilepsy (TLE). However, translating these to cell-specific druggable hypotheses is not explored. Herein, we conducted an integrative insilico-analysis of an available transcript
Externí odkaz:
https://doaj.org/article/96f33045d9774ed79f416b8982c1c3dd
Autor:
Doris Lam, Aimy Sebastian, Chandrakumar Bogguri, Nicholas R. Hum, Alexander Ladd, Jose Cadena, Carlos A. Valdez, Nicholas O. Fischer, Gabriela G. Loots, Heather A. Enright
Publikováno v:
Frontiers in Toxicology, Vol 4 (2022)
Fentanyl is one of the most common opioid analgesics administered to patients undergoing surgery or for chronic pain management. While the side effects of chronic fentanyl abuse are recognized (e.g., addiction, tolerance, impairment of cognitive func
Externí odkaz:
https://doaj.org/article/e29acf262dd54a4293736846a13d9a09
Autor:
Abisola Abisoye-Ogunniyan, Isabella M. Carrano, Dina R. Weilhammer, Sean F. Gilmore, Nicholas O. Fischer, Sukumar Pal, Luis M. de la Maza, Matthew A. Coleman, Amy Rasley
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
A worldwide estimate of over one million STIs are acquired daily and there is a desperate need for effective preventive as well as therapeutic measures to curtail this global health burden. Vaccines have been the most effective means for the control
Externí odkaz:
https://doaj.org/article/0fdef6d619294b57b153251ba39f8257
Autor:
Dina R. Weilhammer, Alexis D. Dunkle, Tyler Boone, Sean F. Gilmore, Mark Khemmani, Sandra K. G. Peters, Paul D. Hoeprich, Nicholas O. Fischer, Craig D. Blanchette, Adam Driks, Amy Rasley
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Subunit vaccines are theoretically safe and easy to manufacture but require effective adjuvants and delivery systems to yield protective immunity, particularly at critical mucosal sites such as the lung. We investigated nanolipoprotein particles (NLP
Externí odkaz:
https://doaj.org/article/ca91e8ee57e54aeda6984465ee70cda7
Autor:
Jose Cadena, Ana Paula Sales, Doris Lam, Heather A Enright, Elizabeth K Wheeler, Nicholas O Fischer
Publikováno v:
PLoS Computational Biology, Vol 16, Iss 5, p e1007834 (2020)
Neurons form complex networks that evolve over multiple time scales. In order to thoroughly characterize these networks, time dependencies must be explicitly modeled. Here, we present a statistical model that captures both the underlying structural a
Externí odkaz:
https://doaj.org/article/f359b178d0224a089a3eb228b7c4b7e6
Autor:
Delia F. Tifrea, Wei He, Sukumar Pal, Angela C. Evans, Sean F. Gilmore, Nicholas O. Fischer, Amy Rasley, Matthew A. Coleman, Luis M. de la Maza
Publikováno v:
Vaccines, Vol 9, Iss 7, p 755 (2021)
Chlamydia trachomatis is a sexually transmitted bacterium that infects over 130 million individuals worldwide annually. To implement a vaccine, we developed a cell-free co-translational system to express the Chlamydia muridarum major outer membrane p
Externí odkaz:
https://doaj.org/article/f51779adbaa644d184c15c06e7d33201
Autor:
Nicholas R. Hum, Doris Lam, Bryan Petkus, Heather A. Enright, Kristen S. Kulp, Joanne Osburn, Elizabeth K. Wheeler, David A. Soscia, Sandra K. G. Peters, Ana Paula Sales, Jose Cadena, Nicholas O. Fischer, Gabriela G. Loots, Aimy Sebastian
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
Scientific Reports
Scientific reports, vol 10, iss 1
Scientific Reports
Scientific reports, vol 10, iss 1
Brain-on-a-chip systems are designed to simulate brain activity using traditional in vitro cell culture on an engineered platform. It is a noninvasive tool to screen new drugs, evaluate toxicants, and elucidate disease mechanisms. However, successful
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7d8db6a32e53d3d63360194e401cb83
http://link.springer.com/article/10.1038/s41598-020-67691-2
http://link.springer.com/article/10.1038/s41598-020-67691-2