Výsledky vyhledávání - "Nicholas McGregor"

Akademický článek

Molecular Characterization of N-glycan Degradation and Transport in Streptococcus pneumoniae and Its Contribution to Virulence.

Autor: Melissa Robb, Joanne K Hobbs, Shireen A Woodiga, Sarah Shapiro-Ward, Michael D L Suits, Nicholas McGregor, Harry Brumer, Hasan Yesilkaya, Samantha J King, Alisdair B Boraston

Publikováno v: PLoS Pathogens, Vol 13, Iss 1, p e1006090 (2017)

The carbohydrate-rich coating of human tissues and cells provide a first point of contact for colonizing and invading bacteria. Commensurate with N-glycosylation being an abundant form of protein glycosylation that has critical functional roles in th

Externí odkaz: https://doaj.org/article/829893825f9f4a5cae1f8874ab6bcf65

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Structure of a GH51 α-L-arabinofuranosidase from Meripilus giganteus: conserved substrate recognition from bacteria to fungi

Autor: Jens Erik Nielsen, Herman S. Overkleeft, Kristian B. R. M. Krogh, Keith A. Stubbs, Gideon J. Davies, Marta Artola, Johan P. Turkenburg, Nicholas McGregor

Publikováno v: Acta Crystallografica Section D. Structural Biology, 76(11), 1124-1133
Acta Crystallographica. Section D, Structural Biology

The structure of a fungal α-l-arabinofuranosidase has been determined using sulfur SAD data collected in vacuo using beamline I23 at Diamond Light Source. Complexes with l-arabinose, an iminosugar and two covalent inhibitors confirm the identity of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd17ba7265eb2563f1008e5fdeb969f2
http://hdl.handle.net/1887/3134980

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Rational Design of Mechanism-Based Inhibitors and Activity-Based Probes for the Identification of Retaining α-L-Arabinofuranosidases

Autor: Jean-Guy Berrin, Jos Reijngoud, Marie-Noëlle Rosso, D. Linzel, Herman S. Overkleeft, Alba Nin-Hill, Gideon J. Davies, G. A. Van Der Marel, G.P. van Wezel, Jeroen D. C. Codée, Marta Artola, Mireille Haon, Carme Rovira, Arthur F. J. Ram, Nicholas McGregor

Publikováno v: Journal of the American Chemical Society
Journal of the American Chemical Society, American Chemical Society, 2020, ⟨10.1021/jacs.9b11351⟩
Journal of the American Chemical Society, 142(10), 4648-4662
Journal of the American Chemical Society, 2020, ⟨10.1021/jacs.9b11351⟩

Identifying and characterizing the enzymes responsible for an observed activity within a complex eukaryotic catabolic system remains one of the most significant challenges in the study of biomass-degrading systems. The debranching of both complex hem

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::934d42b8426e125ab3c7e4e95a374cf4
https://hal.archives-ouvertes.fr/hal-02482205

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Dynamic and Functional Profiling of Xylan-Degrading Enzymes in Aspergillus Secretomes Using Activity-Based Probes

Publikováno v: ACS Central Science, 5(6), 1067-1078
ACS Central Science, . (2019)
ACS Central Science
ACS Central Science, 2019, ⟨10.1021/acscentsci.9b00221⟩
ACS Central Science, ACS Publications, 2019, ⟨10.1021/acscentsci.9b00221⟩
ACS Central Science, Vol 5, Iss 6, Pp 1067-1078 (2019)

International audience; Plant polysaccharides represent a virtually unlimited feedstock for the generation of biofuels and other commodities. However, the extraordinary recalcitrance of plant polysaccharides toward breakdown necessitates a continued

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e8566695ec7f168f7770a99376bf7ac
https://europepmc.org/articles/PMC6598175/

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Correction: Glycosylated cyclophellitol-derived activity-based probes and inhibitors for cellulases

Autor: Bogdan I. Florea, Arthur F. J. Ram, Nicholas McGregor, Evert Peterse, Jianbing Jiang, Herman S. Overkleeft, Jeroen D. C. Codée, Jos Reijngoud, Gideon J. Davies, Gijsbert A. van der Marel, Sybrin P. Schröder, Gilles P. van Wezel, Casper de Boer

Publikováno v: RSC Chemical Biology

Cellulases and related β-1,4-glucanases are essential components of lignocellulose-degrading enzyme mixtures. The detection of β-1,4-glucanase activity typically relies on monitoring the breakdown of purified lignocellulose-derived substrates or sy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::002b3b5177ea2bc5f15699a670f296fa
https://doi.org/10.1039/d1cb90031e

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Structural Dynamics and Catalytic Properties of a Multimodular Xanthanase

Publikováno v: ACS Catalysis
ACS Catalysis, 2018, 8 (7), pp.6021-6034. ⟨10.1021/acscatal.8b00666⟩
Roskilde University
ACS Catalysis, American Chemical Society, 2018, 8 (7), pp.6021-6034. ⟨10.1021/acscatal.8b00666⟩

International audience; The precise catalytic strategies used for the breakdown of the complex bacterial polysaccharide xanthan, an increasingly frequent component of processed human foodstuffs, have remained a mystery. Here, we present characterizat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58c0893a6fd432ee441f20d68430883d
https://hal.inrae.fr/hal-02621066

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Quantitative Kinetic Characterization of Glycoside Hydrolases Using High-Performance Anion-Exchange Chromatography (HPAEC)

Autor: Nicholas, McGregor, Gregory, Arnal, Harry, Brumer

Publikováno v: Methods in molecular biology (Clifton, N.J.). 1588

High-performance anion-exchange chromatography coupled to pulsed amperometric detection (HPAEC-PAD) is a powerful analytical technique enabling the high-resolution separation and sensitive quantification of oligosaccharides. Here, we describe a gener

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::eaf4c0e26e248e4b865d42d6185f1ad2
https://pubmed.ncbi.nlm.nih.gov/28417357

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Quantitative Kinetic Characterization of Glycoside Hydrolases Using High-Performance Anion-Exchange Chromatography (HPAEC)

Autor: Gregory Arnal, Harry Brumer, Nicholas McGregor

Publikováno v: Methods in Molecular Biology ISBN: 9781493968985

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ef2474910687aa07605c9a8698954582
https://doi.org/10.1007/978-1-4939-6899-2_2

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The Podospora anserina lytic polysaccharide monooxygenase PaLPMO9H catalyzes oxidative cleavage of diverse plant cell wall matrix glycans

Autor: Jean-Guy Berrin, Harry Brumer, Mathieu Fanuel, Sona Garajova, Nicholas McGregor, David Ropartz, Hélène Rogniaux

Publikováno v: Biotechnology for Biofuels
Biotechnology for Biofuels, BioMed Central, 2017, 10 (1), ⟨10.1186/s13068-017-0749-5⟩
Biotechnology for Biofuels, 2017, 10 (1), ⟨10.1186/s13068-017-0749-5⟩
Biotechnology for Biofuels 1 (10), . (2017)

The enzymatic conversion of plant biomass has been recently revolutionized by the discovery of lytic polysaccharide monooxygenases (LPMO) that catalyze oxidative cleavage of polysaccharides. These powerful enzymes are secreted by a large number of fu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::537f2d007d29beeaf3f64b77a51e37d5
https://hal.archives-ouvertes.fr/hal-01499750/document

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The

Autor: Mathieu, Fanuel, Sona, Garajova, David, Ropartz, Nicholas, McGregor, Harry, Brumer, Hélène, Rogniaux, Jean-Guy, Berrin

Publikováno v: Biotechnology for Biofuels

Background The enzymatic conversion of plant biomass has been recently revolutionized by the discovery of lytic polysaccharide monooxygenases (LPMO) that catalyze oxidative cleavage of polysaccharides. These powerful enzymes are secreted by a large n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b9742ad46aadccf717d995dfa0d46af0
https://pubmed.ncbi.nlm.nih.gov/28293293

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