Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Nicholas M.P. King"'
Autor:
Jane Owens, Nicholas M.P. King, Roscoe L. Warner, Kent J. Johnson, David Potter, Jiri Aubrecht, Jane Larkindale, Lindsay Tomlinson, Shelli J. Schomaker, Amy C. Porter, John-Michael Sauer
Publikováno v:
PLoS ONE
PLoS ONE, Vol 15, Iss 5, p e0229753 (2020)
PLoS ONE, Vol 15, Iss 5, p e0229753 (2020)
Serum activities of alanine and aspartate aminotransferases (ALT and AST) are used as gold standard biomarkers for the diagnosis of hepatocellular injury. Since ALT and AST lack liver specificity, the diagnosis of the onset of hepatocellular injury i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da2553bc549ea4310c2ae435d8ce0883
http://europepmc.org/articles/PMC7224523
http://europepmc.org/articles/PMC7224523
Autor:
Raúl J. Andrade, Michael Merz, Jiri Aubrecht, John Michael Sauer, Jens C. Goepfert, Frances Hackman, Herbert L. Bonkovsky, Gerd A. Kullak-Ublick, Patrick Kirby, Thierry Poynard, Francis S. Wolenski, Rachel J. Church, John Marcinak, Nadir Arber, Florian van Bömmel, Robert J. Fontana, Sif Ormarsdottir, Ina Schuppe-Koistinen, Paul B. Watkins, Naga Chalasani, Nicholas M.P. King, Simon Kirby, Shelli J. Schomaker
Publikováno v:
Hepatology. 69:760-773
Current blood biomarkers are suboptimal in detecting drug-induced liver injury (DILI) and predicting its outcome. We sought to characterize the natural variabilty and performance characteristics of fourteen promising DILI biomarker candidates. Serum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ce4688b3454f33aa20d8a9b2a7e5542
https://doi.org/10.1002/hep.29802
https://doi.org/10.1002/hep.29802
Autor:
Elizabeth M. McNally, Deborah Ascheim, Christopher F. Spurney, Kan Hor, Kathi Kinnett, Linda H. Cripe, Nicholas M.P. King, Larry W. Markham, Chet R. Villa, Lawrence Charnas, Lee Sweeney, John-Michael Sauer
Publikováno v:
Open Heart
Open Heart, Vol 8, Iss 1 (2021)
Open Heart, Vol 8, Iss 1 (2021)
Cardiac disease is now the leading cause of death in Duchenne muscular dystrophy (DMD). Clinical evaluations over time have demonstrated asymptomatic cardiac troponin elevations and acute elevations are associated with symptoms and cardiac dysfunctio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a094dc88407b75f2e3e5b3ae8e1e4c11
https://doi.org/10.1136/openhrt-2021-001592
https://doi.org/10.1136/openhrt-2021-001592
Autor:
David Serra, Vijay R. More, Steven K. Engle, Matthew Gallacher, Prajakta Shimpi, Michael E. Dunn, Nicholas M.P. King, Thomas G. Manfredi, Kathryn E. Gropp, Heidi M. Colton, Josh Powe, Frederick J. Vetter, Luis A Rodriguez, Kevin Agostinucci
Publikováno v:
Toxicologic Pathology. 45:344-352
Given the proven utility of natriuretic peptides as serum biomarkers of cardiovascular maladaptation and dysfunction in humans and the high cross-species sequence conservation of atrial natriuretic peptides, natriuretic peptides have the potential to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f0d2691f50122c454d6677b129f75f2
https://doi.org/10.1177/0192623316634231
https://doi.org/10.1177/0192623316634231
Autor:
Tanja S. Zabka, Bradley E. Enerson, Michael P. Lawton, Raymond J. Gonzalez, Marshall S. Scicchitano, Peter Hoffmann, Deidre A. Dalmas, Mark Cameron, James L. Weaver, Nicholas M.P. King, Holly W. Smith, Igor Mikaelian, Silvia Guionaud, Roberta A. Thomas
Publikováno v:
Toxicologic Pathology. 42:635-657
Better biomarkers are needed to identify, characterize, and/or monitor drug-induced vascular injury (DIVI) in nonclinical species and patients. The Predictive Safety Testing Consortium (PSTC), a precompetitive collaboration of pharmaceutical companie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::682df031e89863ce652005e46452377f
https://doi.org/10.1177/0192623314525686
https://doi.org/10.1177/0192623314525686
Autor:
Nicholas M.P. King, Henk Granzier, Qianli Yu, Michael H. Radke, Carsten Tschöpe, Dirk Westermann, Douglas F. Larson, Mark McNabb, Siegfried Labeit, Jun Peng, Katharina Rost, O. Lynne Nelson, Michael Gotthardt
Publikováno v:
Circulation Research. 105:557-564
Rationale: The giant protein titin plays key roles in myofilament assembly and determines the passive mechanical properties of the sarcomere. The cardiac titin molecule has 2 mayor elastic elements, the N2B and the PEVK region. Both have been suggest
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c76a03e66c13239e62bf44302df75431
https://doi.org/10.1161/circresaha.109.200964
https://doi.org/10.1161/circresaha.109.200964
Autor:
Heidi Colton, Luis A. Rodriguez, Petra Vinken, Nick Goeminne, Nicholas M.P. King, Wayne R. Buck, William J. Reagan, Ray Liu, Jie Lai-Zhang, Steven K. Engle, Gaby Barbacci
Publikováno v:
Journal of pharmacological and toxicological methods. 77
Introduction Natriuretic peptides, including N-terminal-proatrial natriuretic peptide (NT-proANP) are cardiac hormones that are produced in response to myocardial stretch and have been used in rats and humans as blood based functional cardiac biomark
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a03526ea91d95c3027aa33544b3abb4
https://pubmed.ncbi.nlm.nih.gov/26516096
https://pubmed.ncbi.nlm.nih.gov/26516096
Autor:
Henk Granzier, Nicholas M.P. King, Guillermo Torre-Amione, Siegfried Labeit, Sunshine Lahmers, Yiming Wu, Katy Becker, Gopi Shah, Christian C. Witt, Sherif F. Nagueh
Publikováno v:
Circulation. 110:155-162
Background— The role of the giant protein titin in patients with heart failure is not well established. We investigated titin expression in patients with end-stage heart failure resulting from nonischemic dilated cardiomyopathy, in particular as it
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bc2c4f1a972696f6aa4f4d5f67fe2f1
https://doi.org/10.1161/01.cir.0000135591.37759.af
https://doi.org/10.1161/01.cir.0000135591.37759.af
Autor:
Joshua Nedrud, Methajit Methawasin, Henk Granzier, Nicholas M.P. King, Charles S. Chung, Michiel Helmes
Publikováno v:
Biophysical Journal. 100(3)
We investigated the contribution of actomyosin interactions in unactivated intact and skinned cardiomyocytes in physiologic conditions.A carbon fiber based cell-attachment system was used to measure the diastolic stress-sarcomere length (SL) relation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2693380ab665951552941125ea343a28
Autor:
Ornella I. Selmin, Raymond B. Runyan, Henk Granzier, Nicholas M.P. King, Om Makwana, Lauren Ahles
Publikováno v:
Cardiovascular toxicology. 10(2)
Trichloroethylene is an organic solvent used as an industrial degreasing agent. Due to its widespread use and volatile nature, TCE is a common environmental contaminant. Trichloroethylene exposure has been implicated in the etiology of heart defects
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::147ac8b1305709536ad95453f697015e
https://pubmed.ncbi.nlm.nih.gov/20186580
https://pubmed.ncbi.nlm.nih.gov/20186580