Výsledky vyhledávání - "Nicholas M. Waltz"

Use of Gastrointestinal Simulator, Mass Transport Analysis, and Absorption Simulation to Investigate the Impact of pH Modifiers in Mitigating Weakly Basic Drugs’ Performance Issues Related to Gastric pH: Palbociclib Case Study

Autor: Gislaine Kuminek, Niloufar Salehi, Nicholas M. Waltz, David C. Sperry, Dale E. Greenwood, Siddhi S. Hate, Gregory E. Amidon

Publikováno v: Molecular Pharmaceutics. 20:147-158

It is well known that reduced gastric acidity, for example with concomitant administration of acid reducing agents, can result in variable pharmacokinetics and decreased absorption of weakly basic drugs. It is important to identify the risk of reduce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ef46657843d2dfc1941966ce7d6411e
https://doi.org/10.1021/acs.molpharmaceut.2c00545

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Improving Dissolution Behavior and Oral Absorption of Drugs with pH-Dependent Solubility Using pH Modifiers: A Physiologically Realistic Mass Transport Analysis

Autor: Jozef Al-Gousous, Gislaine Kuminek, David C. Sperry, Gordon L. Amidon, Nicholas M Waltz, Dale Greenwood, Gregory E. Amidon, Niloufar Salehi, Robert M. Ziff

Publikováno v: Molecular Pharmaceutics. 18:3326-3341

Orally dosed drugs must dissolve in the gastrointestinal (GI) tract before being absorbed through the epithelial cell membrane. In vivo drug dissolution depends on the GI tract's physiological conditions such as pH, residence time, luminal buffers, i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db85072cd8755b354c426bb44bb0e14f
https://doi.org/10.1021/acs.molpharmaceut.1c00262

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