Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Nicholas M. Thomson"'
Publikováno v:
Annals of Microbiology, Vol 74, Iss 1, Pp 1-12 (2024)
Abstract Purpose It has previously been shown that organic acids produced by Escherichia coli suppress the growth of Pseudomonas aeruginosa in co-cultures under conditions of glucose excess, due to overflow metabolism. Inactivation of genes involved
Externí odkaz:
https://doaj.org/article/391596573e344fa19aa643c9d235e011
Autor:
Dave J. Baker, Alp Aydin, Thanh Le-Viet, Gemma L. Kay, Steven Rudder, Leonardo de Oliveira Martins, Ana P. Tedim, Anastasia Kolyva, Maria Diaz, Nabil-Fareed Alikhan, Lizzie Meadows, Andrew Bell, Ana Victoria Gutierrez, Alexander J. Trotter, Nicholas M. Thomson, Rachel Gilroy, Luke Griffith, Evelien M. Adriaenssens, Rachael Stanley, Ian G. Charles, Ngozi Elumogo, John Wain, Reenesh Prakash, Emma Meader, Alison E. Mather, Mark A. Webber, Samir Dervisevic, Andrew J. Page, Justin O’Grady
Publikováno v:
Genome Medicine, Vol 13, Iss 1, Pp 1-11 (2021)
Abstract We present CoronaHiT, a platform and throughput flexible method for sequencing SARS-CoV-2 genomes (≤ 96 on MinION or > 96 on Illumina NextSeq) depending on changing requirements experienced during the pandemic. CoronaHiT uses transposase-b
Externí odkaz:
https://doaj.org/article/98dd46104e6f4fbca3a45aad81ec5d08
Autor:
Nicholas M. Thomson, Mark J. Pallen
Publikováno v:
Current Research in Biotechnology, Vol 2, Iss , Pp 45-52 (2020)
Flagellin is the major constituent of the flagellar filament and faithful restoration of wild-type motility to flagellin mutants may be beneficial for studies of flagellar biology and biotechnological exploitation of the flagellar system. However, ge
Externí odkaz:
https://doaj.org/article/023ea0fd8afa4c4b9bbb6116f4c6e834
Autor:
Nicholas M. Thomson, Rachel Gilroy, Maria Getino, Ebenezer Foster-Nyarko, Arnoud H.M. van Vliet, Roberto M. La Ragione, Mark J. Pallen
Publikováno v:
PeerJ, Vol 10, p e12935 (2022)
The genus Escherichia has been extensively studied and it is known to encompass a range of commensal and pathogenic bacteria that primarily inhabit the gastrointestinal tracts of warm-blooded vertebrates. However, the presence of E. coli as a model o
Externí odkaz:
https://doaj.org/article/30c06b0594a74e20868957e73ac283dc
Publikováno v:
BMC Biotechnology, Vol 20, Iss 1, Pp 1-10 (2020)
Abstract Background Gene doctoring is an efficient recombination-based genetic engineering approach to mutagenesis of the bacterial chromosome that combines the λ-Red recombination system with a suicide donor plasmid that is cleaved in vivo to gener
Externí odkaz:
https://doaj.org/article/8c270e9c621046d1aea88e7d5d651343
Publikováno v:
PLoS ONE, Vol 13, Iss 11, p e0206544 (2018)
Flagella, the primary means of motility in bacteria, are helical filaments that function as microscopic propellers composed of thousands of copies of the protein flagellin. Here, we show that many bacteria encode "giant" flagellins, greater than a th
Externí odkaz:
https://doaj.org/article/2a1b6c823e424b43a9a462bbfdc3df0e
Autor:
Nicholas M. Thomson, A. Keith Turner, Muhammad Yasir, Sarah Bastkowski, Martin Lott, Mark A. Webber, Ian G. Charles
Publikováno v:
Frontiers in Antibiotics. 1
We report here the identification of four gene functions of principal importance for the tolerance of meropenem stress in Escherichia coli: cell division, cell envelope synthesis and maintenance, ATP metabolism, and transcription regulation. The prim
Autor:
Alexander J. Trotter, Emma Meader, Maria Diaz, Alp Aydin, Ana Victoria Gutierrez, Lizzie Meadows, Reenesh Prakash, Steven Rudder, Ana P. Tedim, Alison E. Mather, Anastasia Kolyva, Justin O'Grady, Andrew J. Page, Dave Baker, Thanh Le-Viet, Mark A. Webber, Ian G. Charles, Nicholas M. Thomson, Evelien M. Adriaenssens, Leonardo de Oliveira Martins, Rachel Gilroy, Rachael Stanley, Nabil-Fareed Alikhan, John Wain, Samir Dervisevic, Gemma L. Kay, Ngozi Elumogo, Andrew Bell, Luke Griffith
Publikováno v:
Genome Medicine, Vol 13, Iss 1, Pp 1-11 (2021)
Genome Medicine
Genome Medicine
The COVID-19 pandemic has spread to almost every country in the world since it started in China in late 2019. Controlling the pandemic requires a multifaceted approach including whole genome sequencing to support public health interventions at local
Autor:
Nicholas M, Thomson, Rachel, Gilroy, Maria, Getino, Ebenezer, Foster-Nyarko, Arnoud H M, van Vliet, Roberto M, La Ragione, Mark J, Pallen
Publikováno v:
PeerJ. 10
The genus
Autor:
Colin S Brown, Maria Diaz, Luke Bedford, Ana P. Tedim, Steven Rudder, Meera Chand, Muhammad Yasir, Luke Griffith, Will Potter, Rachel Gilroy, Nicholas M. Thomson, Rachael Stanley, Emma Meader, Robert A Kingsley, Ana Victoria Gutierrez, S. J. Louise Smith, Thanh Le-Viet, John Wain, Ian G. Charles, Alexander J. Trotter, Alp Aydin, Ngozi Elumogo, Justin O'Grady, Gemma L. Kay, Reenesh Prakash, Dheeraj K. Sethi, Rose K Davidson, Claire Stuart, Evelien M. Adriaenssens, Alison E Mather, Dinesh Aggarwal, Nabil-Fareed Alikhan, Andrew J. Page, Lizzie Meadows, Anastasia Kolyva, David Baker, Mark A. Webber, Lindsay Coupland, Leonardo de Oliveira Martins, Andrew Bell, Tracey E. Swingler, Samir Dervisevic
Publikováno v:
Microbial genomics
The COVID-19 pandemic has spread rapidly throughout the world. In the UK, the initial peak was in April 2020; in the county of Norfolk (UK) and surrounding areas, which has a stable, low-density population, over 3200 cases were reported between March