Zobrazeno 1 - 10
of 71
pro vyhledávání: '"Nicholas M. Smith"'
Autor:
Jan Naseer Kaur, Navaldeep Singh, Nicholas M. Smith, Jack F. Klem, Raymond Cha, Yinzhi Lang, Liang Chen, Barry Kreiswirth, Patricia N. Holden, Jürgen B. Bulitta, Brian T. Tsuji
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-9 (2024)
Abstract Antimicrobial resistance has emerged as one of the leading public health threats of the twenty-first century. Gram-negative pathogens have been a major contributor to the declining efficacy of antibiotics through both acquired resistance and
Externí odkaz:
https://doaj.org/article/7f6679478e6646e4b2715cd7705e81b5
Autor:
Nicholas M. Smith, Harpreet Kaur, Ravneet Kaur, Trisha Minoza, Michael Kent, Ayeh Barekat, Justin R. Lenhard
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
ObjectivesWe sought to evaluate the pharmacodynamics of β-lactam antibacterials against polymicrobial communities of clinically relevant gram-positive and gram-negative pathogens.MethodsTwo Enterococcus faecalis isolates, two Staphylococcus aureus i
Externí odkaz:
https://doaj.org/article/26154e8a04c14c278093f44a36b494f5
Autor:
Nicholas M. Smith, Thomas D. Nguyen, Wai Hoe Chin, Jacob T. Sanborn, Harriet de Souza, Brian M. Ho, Tiffany Luong, Dwayne R. Roach
Publikováno v:
Frontiers in Microbiology, Vol 14 (2023)
Bacteriophage (phage) therapy is being explored as a possible response to the antimicrobial resistance public health emergency. Administering a mixture of different phage types as a cocktail is one proposed strategy for therapeutic applications, but
Externí odkaz:
https://doaj.org/article/fa5a1162f125461eaa56d7c84b7263e8
Publikováno v:
Antibiotics, Vol 11, Iss 1, p 34 (2021)
The emergence of mobile colistin resistance (mcr)-mediated polymyxin resistance has resulted in a significant detriment to the utility of the polymyxins in the clinical setting. Though the risk for horizontal transfer of an mcr-containing plasmid is
Externí odkaz:
https://doaj.org/article/e742ee4a4edb4bbca6862858d4b293ec
Autor:
Nicholas M. Smith, Katie Rose Boissonneault, Liang Chen, Vidmantas Petraitis, Ruta Petraitiene, Xun Tao, Jieqiang Zhou, Yinzhi Lang, Povilas Kavaliauskas, Zackery P. Bulman, Patricia N. Holden, Raymond Cha, Jürgen B. Bulitta, Barry N. Kreiswirth, Thomas J. Walsh, Brian T. Tsuji
Publikováno v:
Antimicrob Agents Chemother
Metallo-β-lactamase (MBL)-producing Gram-negative bacteria cause infections associated with high rates of morbidity and mortality. Currently, a leading regimen to treat infections caused by MBL-producing bacteria is aztreonam combined with ceftazidi
Publikováno v:
Antibiotics, Vol 11, Iss 34, p 34 (2022)
Antibiotics
Antibiotics; Volume 11; Issue 1; Pages: 34
Antibiotics
Antibiotics; Volume 11; Issue 1; Pages: 34
The emergence of mobile colistin resistance (mcr)-mediated polymyxin resistance has resulted in a significant detriment to the utility of the polymyxins in the clinical setting. Though the risk for horizontal transfer of an mcr-containing plasmid is
Autor:
Anant P. Shah, Nicholas M. Smith, Harriet de Souza, Arthur Chan, Laura A Wilkinson, Thomas D. Nguyen, Kari A. Mergenhagen, Hubert C. Chua, David Z. D'Argenio
Publikováno v:
PharmacotherapyREFERENCES. 41(11)
Recent updates in the therapeutic drug monitoring (TDM) guidelines for vancomycin have rekindled interest in maximum a posteriori-Bayesian (MAP-Bayesian) estimation of patient-specific pharmacokinetic parameters. To create a versatile infrastructure
Autor:
Nicholas M. Smith, Katelyn Macias, Justin R. Lenhard, Sarah James, Jasleen Sidhu, Fanny Tan, Alexa Ang
Publikováno v:
Antimicrobial Agents and Chemotherapy. 65
We sought to determine if Acinetobacter baumannii is capable of altering the pharmacodynamics of an anti-staphylococcal β-lactam. Two strains of methicillin-susceptible Staphylococcus aureus (MSSA) and two A. baumannii isolates were studied in 24-h
Publikováno v:
European Journal of Heart Failure
Autor:
Nicholas M, Smith, Alexa, Ang, Fanny, Tan, Katelyn, Macias, Sarah, James, Jasleen, Sidhu, Justin R, Lenhard
Publikováno v:
Antimicrob Agents Chemother
We sought to determine if Acinetobacter baumannii is capable of altering the pharmacodynamics of an antistaphylococcal β-lactam. Two strains of methicillin-susceptible Staphylococcus aureus (MSSA) and two A. baumannii isolates were studied in 24-h s