Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Nicholas M. Njuguna"'
Autor:
Agnes W. Mathenge, Paul M. Njaria, Alex Njoroge Mwangi, Shital M. Maru, Geoffrey Kabue Kiriiri, Nicholas M. Njuguna, Peter M. Njogu
Publikováno v:
Saudi Pharmaceutical Journal : SPJ
Purpose The study designed, formulated and evaluated meloxicam emulgels as a potential alternative topical treatment option for rheumatism. Methods A 32 factorial design was employed to formulate nine preliminary meloxicam emulgels (Formulations F1
Publikováno v:
Cogent Medicine, Vol 7, Iss 1 (2020)
Objective: Oral dispersible isoniazid 50 mg/pyridoxine 6.25 mg fixed-dose combination (FDC) tablets were formulated for Isoniazid Preventive Therapy in pediatrics weighing less than 5 kg. Significance: The Kenyan clinical market lacks age-appropriate
Publikováno v:
Journal of Herbal Medicine. 29:100475
Herbal medicines’ use is steadily increasing globally, thus creating a compelling need for quality assurance. The present study assessed the microbial contamination of 86 herbal preparations marketed in the Nairobi metropolis used in the management
Publikováno v:
Pharmaceutical Chemistry Journal. 51:153-158
Asimple, rapid isocratic liquid chromatography method was developed for the simultaneous determination of diphenhydramine, promethazine, chlorpheniramine, and ephedrine in cold-cough syrups commonly available in the Kenyan market. The influence of th
Publikováno v:
Expert Opinion on Therapeutic Patents
Introduction: Chloroquine (CQ) has been well known for its antimalarial effects since World War II. However, it is gradually being phased out from clinical use against malaria due to emergence of CQ-resistant Plasmodium falciparum strains. Besides lo
Autor:
Peggoty Mutai, Kelly Chibale, Nicholas M. Njuguna, Dennis S.B. Ongarora, Paul W. Smith, Mathew Njoroge
Publikováno v:
Chemical Reviews. 114:11138-11163
Autor:
Kelly Chibale, Nicholas M. Njuguna, Dennis S.B. Ongarora, Dyanne L. Cruickshank, Mino R. Caira, Yassir Younis
Publikováno v:
CrystEngComm. 16:5781-5792
3-(6-Methoxypyridin-3-yl)-5-(4-methylsulfonyl phenyl)-pyridin-2-amine (MMP) is a member of a novel class of orally active antimalarial drugs. This aminopyridine molecule has shown potent in vitro antiplasmodial activity and in vivo antimalarial activ
Autor:
Digby F. Warner, Kawaljit Singh, Mathew Njoroge, Kelly Chibale, Nicholas M. Njuguna, Elizabeth Kigondu
Publikováno v:
Med. Chem. Commun.. 5:502-506
The antimycobacterial activities of chlorpromazine and its metabolites were evaluated alone and in combination with antitubercular drugs. Although associated with limited antimycobacterial activity when tested individually, chlorpromazine and its met
Autor:
Nicholas M. Njuguna, Felix Huth, Gian Camenisch, Kelly Chibale, Hilmar Schiller, Kenichi Umehara
Publikováno v:
Drug Metabolism and Personalized Therapy. 31
The fraction of an absorbed drug metabolized by the different hepatic cytochrome P450 (CYP) enzymes, relative to total hepatic CYP metabolism (fmCYP), can be estimated by measuring the inhibitory effects of presumably selective CYP inhibitors on the
Autor:
Nicholas M. Njuguna, Julio Caballero, Marlene Espinoza-Moraga, Kelly Chibale, Grace Mugumbate
Publikováno v:
Journal of chemical information and modeling. 53(3)
The chemical space based on physicochemical properties and structural features of a diverse group of natural products with reported in vitro activity against different Mycobacterium tuberculosis strains is investigated using in silico tools. This is