Zobrazeno 1 - 10
of 255
pro vyhledávání: '"Nicholas M. Boulis"'
Publikováno v:
Neurotrauma Reports, Vol 5, Iss 1, Pp 172-180 (2024)
Peripheral nerve injuries (PNIs) are common and devastating. The current standard of care relies on the slow and inefficient process of nerve regeneration after surgical intervention. Electrical stimulation (ES) has been shown to both experimentally
Externí odkaz:
https://doaj.org/article/8d1ddb9511f5456ea59ccf23d5004ae1
Autor:
Muhibullah S. Tora, Stewart G. Neill, Yuliya Lakhina, Hemza Assed, Michelle Zhang, Purva P. Nagarajan, Thais Federici, Juanmarco Gutierrez, Kimberly B. Hoang, Yuhong Du, Kecheng Lei, Nicholas M. Boulis
Publikováno v:
Journal of Translational Medicine, Vol 21, Iss 1, Pp 1-12 (2023)
Abstract Background Spinal cord glioma (SCG) is considered an orphan disease that lacks effective treatment options with margins that are surgically inaccessible and an overall paucity of literature on the topic. The tumor microenvironment is a criti
Externí odkaz:
https://doaj.org/article/32602bf37c574cc6a654e0f3b3fc2421
Autor:
Nicholas M. Boulis, Anthony Donsante
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 29, Iss , Pp 236-237 (2023)
Externí odkaz:
https://doaj.org/article/0b0bdefb5c2b4a56a8825512f3a3b8dd
Autor:
Letizia Mazzini, Maurizio Gelati, Daniela Celeste Profico, Gianni Sorarù, Daniela Ferrari, Massimiliano Copetti, Gianmarco Muzi, Claudia Ricciolini, Sandro Carletti, Cesare Giorgi, Cristina Spera, Domenico Frondizi, Stefano Masiero, Alessandro Stecco, Carlo Cisari, Enrica Bersano, Fabiola De Marchi, Maria Francesca Sarnelli, Giorgia Querin, Roberto Cantello, Francesco Petruzzelli, Annamaria Maglione, Cristina Zalfa, Elena Binda, Alberto Visioli, Domenico Trombetta, Barbara Torres, Laura Bernardini, Alessandra Gaiani, Maurilio Massara, Silvia Paolucci, Nicholas M. Boulis, Angelo L. Vescovi, on behalf of the ALS‐NSCs Trial Study Group
Publikováno v:
Stem Cells Translational Medicine, Vol 8, Iss 9, Pp 887-897 (2019)
Abstract The main objective of this phase I trial was to assess the feasibility and safety of microtransplanting human neural stem cell (hNSC) lines into the spinal cord of patients with amyotrophic lateral sclerosis (ALS). Eighteen patients with a d
Externí odkaz:
https://doaj.org/article/1b266c15eb0b4c92a1cb1b70a47533cf
Autor:
Purva P. Nagarajan, Muhibullah S. Tora, Stewart G. Neill, Thais Federici, Pavlos Texakalidis, Anthony Donsante, Peter Canoll, Kecheng Lei, Nicholas M. Boulis
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 23, p 12943 (2021)
Intramedullary spinal cord tumors are a rare and understudied cancer with poor treatment options and prognosis. Our prior study used a combination of PDGF-B, HRAS, and p53 knockdown to induce the development of high-grade glioma in the spinal cords o
Externí odkaz:
https://doaj.org/article/676bbded09a84088892b4ca2dbe4bb8b
Publikováno v:
Journal of Clinical Medicine, Vol 10, Iss 15, p 3344 (2021)
Ischemic stroke remains a major cause of disability in the United States and worldwide. Following the large-scale implementation of stroke thrombectomy and the optimization of treatment protocols for acute stroke, the reduction in stroke-associated m
Externí odkaz:
https://doaj.org/article/9fc729b45ebc4011b3bb685f85d41626
Autor:
Raymond T. Bartus, Alexandre Bétourné, Anthony Basile, Bethany L. Peterson, Jonathan Glass, Nicholas M. Boulis
Publikováno v:
Neurobiology of Disease, Vol 85, Iss , Pp 11-24 (2016)
Amyotrophic lateral sclerosis (ALS) is a chronic and progressive neuromuscular disease for which no cure exists and better treatment options are desperately needed. We hypothesize that currently approved β2-adrenoceptor agonists may effectively trea
Externí odkaz:
https://doaj.org/article/53c428238159499bacf69212faa14549
Autor:
Thais Federici, Nicholas M. Boulis
Publikováno v:
Neurobiology of Disease, Vol 48, Iss 2, Pp 236-242 (2012)
Gene therapy continues to be a potential option for amyotrophic lateral sclerosis (ALS). This chapter will inform the reader about promising therapeutic transgenes and proof-of-principle studies in transgenic rodent models of ALS. Challenges regardin
Externí odkaz:
https://doaj.org/article/8d39d012833748dbb95532369fe2474a
Autor:
Eleanor M. Donnelly, Eric T. Quach, Terence M. Hillery, Brenten L. Heeke, Brooke R. Snyder, Chalonda R. Handy, Deirdre M. O'Connor, Nicholas M. Boulis, Thais Federici
Publikováno v:
Neurobiology of Disease, Vol 45, Iss 3, Pp 992-998 (2012)
Spinal muscular atrophy (SMA) is an autosomal recessive neuromuscular disease, which is the leading genetic cause of mortality in children. To date no effective treatment exists for SMA. The genetic basis for SMA has been well documented as a mutatio
Externí odkaz:
https://doaj.org/article/8b865ceb2cc341f8b50a0739c7a8b385
Autor:
Colin K. Franz, Thais Federici, Jun Yang, Carey Backus, Sang Su Oh, Qingshan Teng, Erin Carlton, Kathie M. Bishop, Mehdi Gasmi, Raymond T. Bartus, Eva L. Feldman, Nicholas M. Boulis
Publikováno v:
Neurobiology of Disease, Vol 33, Iss 3, Pp 473-481 (2009)
Background: Amyotrophic lateral sclerosis (ALS) is a devastating disease that is characterized by the progressive loss of motor neurons. Patients with ALS usually die from respiratory failure due to respiratory muscle paralysis. Consequently, therapi
Externí odkaz:
https://doaj.org/article/b08a536399554ec89b5daddd1dab6e3b