Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Nicholas M. Adams"'
Autor:
Christia M. Victoriano, Megan E. Pask, Nicole A. Malofsky, Adam Seegmiller, Steve Simmons, Jonathan E. Schmitz, Frederick R. Haselton, Nicholas M. Adams
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract PCR-based diagnostics generally require nucleic acid extraction from patient specimens prior to amplification. As highlighted early in the COVID-19 pandemic, extraction steps may be difficult to scale during times of massive demand and limit
Externí odkaz:
https://doaj.org/article/de69f5555a644c808ef462f0d7e32cc4
Autor:
Zackary A. Zimmers, Alexander D. Boyd, Hannah E. Stepp, Nicholas M. Adams, Frederick R. Haselton
Publikováno v:
Micromachines, Vol 12, Iss 10, p 1204 (2021)
Among nucleic acid diagnostic strategies, non-enzymatic tests are the most promising for application at the point of care in low-resource settings. They remain relatively under-utilized, however, due to inadequate sensitivity. Inspired by a recent de
Externí odkaz:
https://doaj.org/article/d20f4db2a4b840f79fbbe34a5360458d
Autor:
Geunhyo Jang, Stephania Contreras Castillo, Eduardo Esteva, Samik Upadhaya, Jue Feng, Nicholas M. Adams, Elodie Richard, Rajeshwar Awatramani, Catherine M. Sawai, Boris Reizis
Publikováno v:
Proceedings of the National Academy of Sciences. 120
Mammalian aging is associated with multiple defects of hematopoiesis, most prominently with the impaired development of T and B lymphocytes. This defect is thought to originate in hematopoietic stem cells (HSCs) of the bone marrow, specifically due t
Autor:
Candace D. McNaughton, Jonathan E. Schmitz, Thomas A. Lasko, Carl Hirschie Johnson, Nicholas M. Adams, Michael J. Ward
Publikováno v:
J Biol Rhythms
False negative tests for SARS-CoV-2 are common and have important public health and medical implications. We tested the hypothesis of diurnal variation in viral shedding by assessing the proportion of positive versus negative SARS-CoV-2 reverse trans
Autor:
Endi K. Santosa, Simon Grassmann, Sam Sheppard, Gabriela M. Wiedemann, Colleen M. Lau, Jean-Benoît Le Luduec, Joseph C. Sun, Katharine C. Hsu, Nicholas M. Adams, Celeste Dang
Publikováno v:
Nat Immunol
Cytokine signaling via signal transducer and activator of transcription (STAT) proteins is crucial for optimal antiviral responses of natural killer (NK) cells. However, the pleiotropic effects of both cytokine and STAT signaling preclude the ability
Autor:
Ioanna Tiniakou, Pei-Feng Hsu, Lorena S. Lopez-Zepeda, Colleen M. Lau, Chetna Soni, Eduardo Esteva, Nicholas M. Adams, Fan Liu, Alireza Khodadadi-Jamayran, Tori C. Rodrick, Drew Jones, Aristotelis Tsirigos, Uwe Ohler, Mark T. Bedford, Stephen D. Nimer, Boris Reizis
SummaryDendritic cells (DCs) are immune sentinel cells that comprise antigen-presenting conventional DCs (cDCs) and cytokine-producing plasmacytoid DCs (pDCs). Cytokine Flt3 ligand (Flt3L) supports the proliferation of hematopoietic progenitors, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1d54502faa257f498110d4ce7e273bd4
https://doi.org/10.1101/2022.05.11.491577
https://doi.org/10.1101/2022.05.11.491577
Publikováno v:
J Immunol
Heterogeneity among naive adaptive lymphocytes determines their individual functions and fate decisions during an immune response. NK cells are innate lymphocytes capable of generating “adaptive” responses during infectious challenges. However, t
Autor:
Erin M. Euliano, Nicholas M. Adams, William E. Gabella, Frederick R. Haselton, Austin N. Hardcastle, Christia M. Victoriano
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)
Scientific Reports
Scientific Reports
Reverse transcription polymerase chain reaction (RT-PCR) is the gold standard for the molecular diagnosis of many infectious diseases, including RNA viruses, but is generally limited to settings with access to trained personnel and laboratory resourc
Autor:
Xi Chen, Jin Cao, James R. Carlyle, Joseph C. Sun, David S.J. Allan, Han Dong, Nicholas M. Adams, Yichi Xu, Laurie H. Glimcher
Publikováno v:
Nature Immunology. 20:865-878
Natural killer (NK) cells are critical mediators of host immunity to pathogens. Here, we demonstrate that the endoplasmic reticulum stress sensor inositol-requiring enzyme 1 (IRE1α) and its substrate transcription factor X-box-binding protein 1 (XBP
Autor:
Nicholas M. Adams, Candace D. McNaughton, Michael J. Ward, Carl Hirschie Johnson, Thomas A. Lasko
False negative tests for SARS-CoV-2 are common and have important public health and medical implications. We tested the hypothesis that the proportion of positive SARS-CoV-2 real-time polymerase chain reaction (RT-PCR) tests varied by time of day, su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1decfffbe6cf601389ce6b3b1e524e1d
https://doi.org/10.1101/2021.03.12.21253015
https://doi.org/10.1101/2021.03.12.21253015