Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Nicholas M Pearce"'
Autor:
Daniel A Keedy, Zachary B Hill, Justin T Biel, Emily Kang, T Justin Rettenmaier, José Brandão-Neto, Nicholas M Pearce, Frank von Delft, James A Wells, James S Fraser
Publikováno v:
eLife, Vol 7 (2018)
Allostery is an inherent feature of proteins, but it remains challenging to reveal the mechanisms by which allosteric signals propagate. A clearer understanding of this intrinsic circuitry would afford new opportunities to modulate protein function.
Externí odkaz:
https://doaj.org/article/f31e59e6c613444c8e3b921c3cf0906f
Autor:
Nicholas M. Pearce, Piet Gros
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Here, the authors present a hierarchical disorder model for the analysis of disorder in both crystal and cryo-EM structures. They apply their approach to several structures of three proteins, including SARS-CoV-2 proteins, and discuss mechanistic and
Externí odkaz:
https://doaj.org/article/4f91ff9851374d8cac908210c30b09f1
Autor:
Manfred S. Weiss, Jan Wollenhaupt, Galen J. Correy, James S. Fraser, Andreas Heine, Gerhard Klebe, Tobias Krojer, Marjolein Thunissen, Nicholas M. Pearce
Publikováno v:
Protein science : a publication of the Protein Society, vol 31, iss 9
Weiss, M S, Wollenhaupt, J, Correy, G J, Fraser, J S, Heine, A, Klebe, G, Krojer, T, Thunissen, M & Pearce, N M 2022, ' Of problems and opportunities—How to treat and how to not treat crystallographic fragment screening data ', Protein Science, vol. 31, no. 9, e4391, pp. 1-5 . https://doi.org/10.1002/pro.4391
Protein Science, 31(9):e4391, 1-5. Cold Spring Harbor Laboratory Press
Weiss, M S, Wollenhaupt, J, Correy, G J, Fraser, J S, Heine, A, Klebe, G, Krojer, T, Thunissen, M & Pearce, N M 2022, ' Of problems and opportunities—How to treat and how to not treat crystallographic fragment screening data ', Protein Science, vol. 31, no. 9, e4391, pp. 1-5 . https://doi.org/10.1002/pro.4391
Protein Science, 31(9):e4391, 1-5. Cold Spring Harbor Laboratory Press
In their recent commentary in Protein Science, Jaskolski et al. analyzed three randomly picked diffraction data sets from fragment-screening group depositions from the PDB and, based on that, they claimed that such data are principally problematic. W
Autor:
Nicholas M. Pearce, Tobias Krojer, Anthony R. Bradley, Patrick Collins, Radosław P. Nowak, Romain Talon, Brian D. Marsden, Sebastian Kelm, Jiye Shi, Charlotte M. Deane, Frank von Delft
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-8 (2017)
Building a ligand into a weak region of an electron density map of a protein is a subjective process. Here, the authors present a new method to obtain a clear electron density for a bound ligand based on multi-crystal experiments and 3D background co
Externí odkaz:
https://doaj.org/article/c88bb825cf794f33ac6c39f01dd123b7
Autor:
Alan Gerber, Sven Hennig, Rosa Bellavita, Isabel Everard, Thirza van Ramshorst, Elisabetta Chiarparin, Nina Louisa Efrém, Nicholas M Pearce, Paul R. J. Davey, Tom N. Grossmann, Paolo Grieco, Mathias Wendt, Mercedes Vazquez-Chantada
Publikováno v:
Angewandte Chemie (International Ed. in English)
Angewandte Chemie-International Edition, 60(25), 13937-13944. Wiley
Wendt, M, Bellavita, R, Gerber, A, Efrém, N L, van Ramshorst, T, Pearce, N M, Davey, P R J, Everard, I, Vazquez-Chantada, M, Chiarparin, E, Grieco, P, Hennig, S & Grossmann, T N 2021, ' Bicyclic β-Sheet Mimetics that Target the Transcriptional Coactivator β-Catenin and Inhibit Wnt Signaling ', Angewandte Chemie-International Edition, vol. 60, no. 25, pp. 13937-13944 . https://doi.org/10.1002/anie.202102082
Angewandte Chemie-International Edition, 60(25), 13937-13944. John Wiley and Sons Ltd
Angewandte Chemie-International Edition, 60(25), 13937-13944. Wiley
Wendt, M, Bellavita, R, Gerber, A, Efrém, N L, van Ramshorst, T, Pearce, N M, Davey, P R J, Everard, I, Vazquez-Chantada, M, Chiarparin, E, Grieco, P, Hennig, S & Grossmann, T N 2021, ' Bicyclic β-Sheet Mimetics that Target the Transcriptional Coactivator β-Catenin and Inhibit Wnt Signaling ', Angewandte Chemie-International Edition, vol. 60, no. 25, pp. 13937-13944 . https://doi.org/10.1002/anie.202102082
Angewandte Chemie-International Edition, 60(25), 13937-13944. John Wiley and Sons Ltd
Protein complexes are defined by the three‐dimensional structure of participating binding partners. Knowledge about these structures can facilitate the design of peptidomimetics which have been applied for example, as inhibitors of protein–protei
Autor:
Nicholas M. Pearce, Anthony R. Bradley, Tobias Krojer, Brian D. Marsden, Charlotte M. Deane, Frank von Delft
Publikováno v:
Structural Dynamics, Vol 4, Iss 3, Pp 032104-032104-9 (2017)
Crystallographic fragment screening uses low molecular weight compounds to probe the protein surface and although individual protein-fragment interactions are high quality, fragments commonly bind at low occupancy, historically making identification
Externí odkaz:
https://doaj.org/article/cdde16e1b96246b997599d4048614c67
Publikováno v:
Frontiers in molecular biosciences. 9
The throughput of macromolecular X-ray crystallography experiments has surged over the last decade. This remarkable gain in efficiency has been facilitated by increases in the availability of high-intensity X-ray beams, (ultra)fast detectors and high
Autor:
Thomas M, Wood, Matthieu R, Zeronian, Ned, Buijs, Kristine, Bertheussen, Hanieh K, Abedian, Aidan V, Johnson, Nicholas M, Pearce, Martin, Lutz, Johan, Kemmink, Tjalling, Seirsma, Leendert W, Hamoen, Bert J C, Janssen, Nathaniel I, Martin
Publikováno v:
Chemical science. 13(10)
The continued rise of antibiotic resistance is a global concern that threatens to undermine many aspects of modern medical practice. Key to addressing this threat is the discovery and development of new antibiotics that operate by unexploited modes o
Autor:
Louise E. Bird, Muhammad Faheem, Juliana Roberta Torini, Nicholas M Pearce, Humberto D'Muniz Pereira, Raymond J. Owens, José Brandão-Neto, Dom Bellini, João Alexandre Ribeiro Gonçalves Barbosa, Frank von Delft, Napoleão Fonseca Valadares, P.M. Collins
Publikováno v:
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Universidade de São Paulo (USP)
instacron:USP
Several Schistosoma species cause Schistosomiasis, an endemic disease in 78 countries that is ranked second amongst the parasitic diseases in terms of its socioeconomic impact and human health importance. The drug recommended for treatment by the WHO
Autor:
Piet Gros, Paul M. P. van Bergen en Henegouwen, Martin Lutz, Loes M. J. Kroon-Batenburg, Nicholas M. Pearce, Jip Manshande, Sofia Doulkeridou, Wouter Pos, Viviana Neviani, Katerina T. Xenaki, Wout Oosterheert
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::68f7767ade0143944e02599102de7c41
https://doi.org/10.15252/rc.2022546203
https://doi.org/10.15252/rc.2022546203