Zobrazeno 1 - 10
of 204
pro vyhledávání: '"Nicholas M Luscombe"'
Autor:
Alexandre P Thiery, Ailin Leticia Buzzi, Eva Hamrud, Chris Cheshire, Nicholas M Luscombe, James Briscoe, Andrea Streit
Publikováno v:
eLife, Vol 12 (2023)
The vertebrate ‘neural plate border’ is a transient territory located at the edge of the neural plate containing precursors for all ectodermal derivatives: the neural plate, neural crest, placodes and epidermis. Elegant functional experiments in
Externí odkaz:
https://doaj.org/article/9b42e2be862a4735ace0ce2c307ddd07
Autor:
Katherine E Trevers, Hui-Chun Lu, Youwen Yang, Alexandre P Thiery, Anna C Strobl, Claire Anderson, Božena Pálinkášová, Nidia MM de Oliveira, Irene M de Almeida, Mohsin AF Khan, Natalia Moncaut, Nicholas M Luscombe, Leslie Dale, Andrea Streit, Claudio D Stern
Publikováno v:
eLife, Vol 12 (2023)
During early vertebrate development, signals from a special region of the embryo, the organizer, can redirect the fate of non-neural ectoderm cells to form a complete, patterned nervous system. This is called neural induction and has generally been i
Externí odkaz:
https://doaj.org/article/e71ffa06fd894781bce97c9289058beb
Autor:
Radhika A Varier, Theodora Sideri, Charlotte Capitanchik, Zornitsa Manova, Enrica Calvani, Alice Rossi, Raghu R Edupuganti, Imke Ensinck, Vincent WC Chan, Harshil Patel, Joanna Kirkpatrick, Peter Faull, Ambrosius P Snijders, Michiel Vermeulen, Markus Ralser, Jernej Ule, Nicholas M Luscombe, Folkert J van Werven
Publikováno v:
eLife, Vol 11 (2022)
N6- methyladenosine (m6A) RNA modification impacts mRNA fate primarily via reader proteins, which dictate processes in development, stress, and disease. Yet little is known about m6A function in Saccharomyces cerevisiae, which occurs solely during ea
Externí odkaz:
https://doaj.org/article/1fdf12dea2744b80b90c259dff7abe55
Publikováno v:
PLoS ONE, Vol 13, Iss 8, p e0202344 (2018)
Prognostic modelling is important in clinical practice and epidemiology for patient management and research. Electronic health records (EHR) provide large quantities of data for such models, but conventional epidemiological approaches require signifi
Externí odkaz:
https://doaj.org/article/d89565fbdcc044bfa000e188b6070366
Autor:
Borbala Mifsud, Inigo Martincorena, Elodie Darbo, Robert Sugar, Stefan Schoenfelder, Peter Fraser, Nicholas M Luscombe
Publikováno v:
PLoS ONE, Vol 12, Iss 4, p e0174744 (2017)
Hi-C is one of the main methods for investigating spatial co-localisation of DNA in the nucleus. However, the raw sequencing data obtained from Hi-C experiments suffer from large biases and spurious contacts, making it difficult to identify true inte
Externí odkaz:
https://doaj.org/article/34572f7f552f4608b385e9edc53e4c30
Autor:
Sophia M Blake, Stefan H Stricker, Hanna Halavach, Anna R Poetsch, George Cresswell, Gavin Kelly, Nnennaya Kanu, Silvia Marino, Nicholas M Luscombe, Steven M Pollard, Axel Behrens
Publikováno v:
eLife, Vol 5 (2016)
Glioblastoma multiforme (GBM) is the most aggressive human primary brain cancer. Using a Trp53-deficient mouse model of GBM, we show that genetic inactivation of the Atm cofactor Atmin, which is dispensable for embryonic and adult neural development,
Externí odkaz:
https://doaj.org/article/073bb96623004e5382578e901c23c945
Publikováno v:
eLife, Vol 2 (2013)
Transcriptional control ensures genes are expressed in the right amounts at the correct times and locations. Understanding quantitatively how regulatory systems convert input signals to appropriate outputs remains a challenge. For the first time, we
Externí odkaz:
https://doaj.org/article/f63e9308fc4043c79013e2829f0c7b6d
Autor:
Kin Chung Lam, Friederike Mühlpfordt, Juan M Vaquerizas, Sunil Jayaramaiah Raja, Herbert Holz, Nicholas M Luscombe, Thomas Manke, Asifa Akhtar
Publikováno v:
PLoS Genetics, Vol 8, Iss 6, p e1002736 (2012)
MOF is the major histone H4 lysine 16-specific (H4K16) acetyltransferase in mammals and Drosophila. In flies, it is involved in the regulation of X-chromosomal and autosomal genes as part of the MSL and the NSL complexes, respectively. While the func
Externí odkaz:
https://doaj.org/article/2f69c88ba54942c397e24b7221410fc5
Autor:
Zhen Wang, Melis Kayikci, Michael Briese, Kathi Zarnack, Nicholas M Luscombe, Gregor Rot, Blaž Zupan, Tomaž Curk, Jernej Ule
Publikováno v:
PLoS Biology, Vol 8, Iss 10, p e1000530 (2010)
The regulation of alternative splicing involves interactions between RNA-binding proteins and pre-mRNA positions close to the splice sites. T-cell intracellular antigen 1 (TIA1) and TIA1-like 1 (TIAL1) locally enhance exon inclusion by recruiting U1
Externí odkaz:
https://doaj.org/article/a8d5a0e896eb4e3c9d1ffb8f295dfa6b
Publikováno v:
PLoS Genetics, Vol 6, Iss 2, p e1000846 (2010)
Transcriptional regulation is one of the most important processes for modulating gene expression. Though much of this control is attributed to transcription factors, histones, and associated enzymes, it is increasingly apparent that the spatial organ
Externí odkaz:
https://doaj.org/article/abe41bae31df4621bab21f95279d6bb7