Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Nicholas M, Provine"'
Autor:
Geng Liu, Wojciech Barczak, Lian Ni Lee, Amit Shrestha, Nicholas M. Provine, Gulsah Albayrak, Hong Zhu, Claire Hutchings, Paul Klenerman, Nicholas B. La Thangue
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-14 (2023)
The clinical HDAC inhibitor zabadinostat increases MHC class I and II expression in dendritic cells, activates T and B cells, and enhances adaptive immune responses to COVID-19 spike protein in mice.
Externí odkaz:
https://doaj.org/article/677c416326a64b9dac386ff4677a2afa
Autor:
Carl-Philipp Hackstein, Dana Costigan, Linnea Drexhage, Claire Pearson, Samuel Bullers, Nicholas Ilott, Hossain Delowar Akther, Yisu Gu, Michael E. B. FitzPatrick, Oliver J. Harrison, Lucy C. Garner, Elizabeth H. Mann, Sumeet Pandey, Matthias Friedrich, Nicholas M. Provine, Holm H. Uhlig, Emanuele Marchi, Fiona Powrie, Paul Klenerman, Emily E. Thornton
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
Interactions between the host immune response and the commensal microbiota play essential roles in health and disease. Here the authors identify a population of MHC class II, innate like, commensal reactive cells in the gut of mice and humans.
Externí odkaz:
https://doaj.org/article/7533503d8e2b41c48a9f686bb5ff0167
Autor:
Anna L. McNaughton, Robert S. Paton, Matthew Edmans, Jonathan Youngs, Judith Wellens, Prabhjeet Phalora, Alex Fyfe, Sandra Belij-Rammerstorfer, Jai S. Bolton, Jonathan Ball, George W. Carnell, Wanwisa Dejnirattisai, Christina Dold, David W. Eyre, Philip Hopkins, Alison Howarth, Kreepa Kooblall, Hannah Klim, Susannah Leaver, Lian Ni Lee, César López-Camacho, Sheila F. Lumley, Derek C. Macallan, Alexander J. Mentzer, Nicholas M. Provine, Jeremy Ratcliff, Jose Slon-Compos, Donal Skelly, Lucas Stolle, Piyada Supasa, Nigel Temperton, Chris Walker, Beibei Wang, Duncan Wyncoll, Oxford Protective T Cell Immunology for COVID-19 (OPTIC) consortium, Scottish National Blood Transfusion Service (SNBTS) consortium, Peter Simmonds, Teresa Lambe, John Kenneth Baillie, Malcolm G. Semple, Peter J.M. Openshaw, International Severe Acute Respiratory and emerging Infection Consortium Coronavirus Clinical Characterisation Consortium (ISARIC4C) investigators, Uri Obolski, Marc Turner, Miles Carroll, Juthathip Mongkolsapaya, Gavin Screaton, Stephen H. Kennedy, Lisa Jarvis, Eleanor Barnes, Susanna Dunachie, José Lourenço, Philippa C. Matthews, Tihana Bicanic, Paul Klenerman, Sunetra Gupta, Craig P. Thompson
Publikováno v:
JCI Insight, Vol 7, Iss 13 (2022)
The role of immune responses to previously seen endemic coronavirus epitopes in severe acute respiratory coronavirus 2 (SARS-CoV-2) infection and disease progression has not yet been determined. Here, we show that a key characteristic of fatal outcom
Externí odkaz:
https://doaj.org/article/842340fbdef543a0831407713fb7ad30
Autor:
Joe N. Frost, David Arnold, Fergus Hamilton, Akshay Shah, Karen T. Elvers, Alice Milne, Andrew E. Armitage, Marie Attwood, Jorgen McKernon, Luzheng Xue, Peter Ghazal, Yi-Ling Chen, Nicholas M. Provine, Jonathan Youngs, Hal Drakesmith, Tihana Bicanic, Paul Klenerman
Publikováno v:
Wellcome Open Research, Vol 7 (2022)
Background: Marked reductions in serum iron concentrations are commonly induced during the acute phase of infection. This phenomenon, termed hypoferremia of inflammation, leads to inflammatory anemia, but could also have broader pathophysiological im
Externí odkaz:
https://doaj.org/article/9e8a2809e69c4cd9a90807bd3fbbf1d6
Autor:
Matthew S. Buckland, James B. Galloway, Caoimhe Nic Fhogartaigh, Luke Meredith, Nicholas M. Provine, Stuart Bloor, Ane Ogbe, Wioleta M. Zelek, Anna Smielewska, Anna Yakovleva, Tiffeney Mann, Laura Bergamaschi, Lorinda Turner, Frederica Mescia, Erik J. M. Toonen, Carl-Philipp Hackstein, Hossain Delowar Akther, Vinicius Adriano Vieira, Lourdes Ceron-Gutierrez, Jimstan Periselneris, Sorena Kiani-Alikhan, Sofia Grigoriadou, Devan Vaghela, Sara E. Lear, M. Estée Török, William L. Hamilton, Joanne Stockton, Josh Quick, Peter Nelson, Michael Hunter, Tanya I. Coulter, Lisa Devlin, CITIID-NIHR COVID-19 BioResource Collaboration, MRC-Toxicology Unit COVID-19 Consortium, John R. Bradley, Kenneth G. C. Smith, Willem H. Ouwehand, Lise Estcourt, Heli Harvala, David J. Roberts, Ian B. Wilkinson, Nick Screaton, Nicholas Loman, Rainer Doffinger, Paul A. Lyons, B. Paul Morgan, Ian G. Goodfellow, Paul Klenerman, Paul J. Lehner, Nicholas J. Matheson, James E. D. Thaventhiran
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Remdesivir is under evaluation for treatment of COVID-19 in clinical trials. Here, the authors report results of remdesivir treatment in a patient with COVID-19 and the genetic antibody deficiency XLA. They show a temporally correlated clinical and v
Externí odkaz:
https://doaj.org/article/c14cbd11e914499b8bdaf50363c87805
Autor:
Hannah R. Sharpe, Nicholas M. Provine, Georgina S. Bowyer, Pedro Moreira Folegatti, Sandra Belij-Rammerstorfer, Amy Flaxman, Rebecca Makinson, Adrian V.S. Hill, Katie J. Ewer, Andrew J. Pollard, Paul Klenerman, Sarah Gilbert, Teresa Lambe
Publikováno v:
JCI Insight, Vol 7, Iss 6 (2022)
Cytomegalovirus (CMV) is a globally ubiquitous pathogen with a seroprevalence of approximately 50% in the United Kingdom. CMV infection induces expansion of immunosenescent T cell and NK cell populations, with these cells demonstrating lower responsi
Externí odkaz:
https://doaj.org/article/e4a4682673c846b98452e03a01c6e769
Autor:
Jonathan Youngs, Nicholas M Provine, Nicholas Lim, Hannah R Sharpe, Ali Amini, Yi-Ling Chen, Jian Luo, Matthew D Edmans, Panagiota Zacharopoulou, Wentao Chen, Oliver Sampson, Robert Paton, William J Hurt, David A Duncan, Anna L McNaughton, Vincent N Miao, Susannah Leaver, Duncan L A Wyncoll, Jonathan Ball, Philip Hopkins, Oxford Immunology Network Covid-19 response T cell Consortium, Oxford Protective T cell Immunology for COVID-19 (OPTIC) Clinical team, Donal T Skelly, Eleanor Barnes, Susanna Dunachie, Graham Ogg, Teresa Lambe, Ian Pavord, Alex K Shalek, Craig P Thompson, Luzheng Xue, Derek C Macallan, Philip Goulder, Paul Klenerman, Tihana Bicanic
Publikováno v:
PLoS Pathogens, Vol 17, Iss 9, p e1009804 (2021)
Prior studies have demonstrated that immunologic dysfunction underpins severe illness in COVID-19 patients, but have lacked an in-depth analysis of the immunologic drivers of death in the most critically ill patients. We performed immunophenotyping o
Externí odkaz:
https://doaj.org/article/ae2109d6ebeb4156b32fca8cdf3e3593
Autor:
Nicholas M Provine
Publikováno v:
Immunology & Cell Biology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f02d69be6bc58d0a5e0514f56bd79c90
https://doi.org/10.1111/imcb.12648
https://doi.org/10.1111/imcb.12648
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Mucosal-associated invariant T (MAIT) cells and invariant natural killer T (iNKT) cells are innate-like T cells that function at the interface between innate and adaptive immunity. They express semi-invariant T cell receptors (TCRs) and recognize unc
Externí odkaz:
https://doaj.org/article/49a645d92d414c3c861403750de968a9
Autor:
Nicholas M. Provine, Benedikt Binder, Michael E. B. FitzPatrick, Anita Schuch, Lucy C. Garner, Kate D. Williamson, Bonnie van Wilgenburg, Robert Thimme, Paul Klenerman, Maike Hofmann
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Mucosal-associated invariant T (MAIT) cells are innate-like T cells abundant in humans that can be activated in a TCR-independent manner by inflammatory and antiviral cytokines. In humans, the capacity for TCR-independent activation is functionally l
Externí odkaz:
https://doaj.org/article/d4d95a5365344813bf961464d276c02a