Zobrazeno 1 - 10
of 204
pro vyhledávání: '"Nicholas M, Luscombe"'
Autor:
Marisol Alvarez-Martinez, Luke S. Cox, Xuemei Wu, Leona Gabryšová, James Briscoe, Raphaëlle Luisier, Nicholas M. Luscombe, Anne O'Garra
Publikováno v:
Wellcome Open Research, Vol 8 (2023)
Background CD4+ Th1 cells producing IFN-γ are required to eradicate intracellular pathogens, however if uncontrolled these cells can cause immunopathology. The cytokine IL-10 is produced by multiple immune cells including Th1 cells during infection
Externí odkaz:
https://doaj.org/article/8fd33ec27fca4212bad436890c69a8b4
Autor:
Alexandre P Thiery, Ailin Leticia Buzzi, Eva Hamrud, Chris Cheshire, Nicholas M Luscombe, James Briscoe, Andrea Streit
Publikováno v:
eLife, Vol 12 (2023)
The vertebrate ‘neural plate border’ is a transient territory located at the edge of the neural plate containing precursors for all ectodermal derivatives: the neural plate, neural crest, placodes and epidermis. Elegant functional experiments in
Externí odkaz:
https://doaj.org/article/9b42e2be862a4735ace0ce2c307ddd07
Autor:
Charlotte West, Chris Cheshire, Charlotte Capitanchik, Nicholas M. Luscombe, Anob Chakrabarti, Jernej Ule
Publikováno v:
Wellcome Open Research, Vol 8 (2023)
Crosslinking and immunoprecipitation (CLIP) technologies have become a central component of the molecular biologists’ toolkit to study protein-RNA interactions and thus to uncover core principles of RNA biology. There has been a proliferation of CL
Externí odkaz:
https://doaj.org/article/92bb60edcbc54ba9b5f6f394a914bf6a
Autor:
Katherine E Trevers, Hui-Chun Lu, Youwen Yang, Alexandre P Thiery, Anna C Strobl, Claire Anderson, Božena Pálinkášová, Nidia MM de Oliveira, Irene M de Almeida, Mohsin AF Khan, Natalia Moncaut, Nicholas M Luscombe, Leslie Dale, Andrea Streit, Claudio D Stern
Publikováno v:
eLife, Vol 12 (2023)
During early vertebrate development, signals from a special region of the embryo, the organizer, can redirect the fate of non-neural ectoderm cells to form a complete, patterned nervous system. This is called neural induction and has generally been i
Externí odkaz:
https://doaj.org/article/e71ffa06fd894781bce97c9289058beb
Autor:
Adrien Leger, Paulo P. Amaral, Luca Pandolfini, Charlotte Capitanchik, Federica Capraro, Valentina Miano, Valentina Migliori, Patrick Toolan-Kerr, Theodora Sideri, Anton J. Enright, Konstantinos Tzelepis, Folkert J. van Werven, Nicholas M. Luscombe, Isaia Barbieri, Jernej Ule, Tomas Fitzgerald, Ewan Birney, Tommaso Leonardi, Tony Kouzarides
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Nanopore direct RNA Sequencing data contain information about the presence of RNA modifications, but their detection poses substantial challenges. Here the authors introduce Nanocompore, a new methodology for modification detection from Nanopore data
Externí odkaz:
https://doaj.org/article/b763993df55a44c68f28be519d53614f
Autor:
Radhika A Varier, Theodora Sideri, Charlotte Capitanchik, Zornitsa Manova, Enrica Calvani, Alice Rossi, Raghu R Edupuganti, Imke Ensinck, Vincent WC Chan, Harshil Patel, Joanna Kirkpatrick, Peter Faull, Ambrosius P Snijders, Michiel Vermeulen, Markus Ralser, Jernej Ule, Nicholas M Luscombe, Folkert J van Werven
Publikováno v:
eLife, Vol 11 (2022)
N6- methyladenosine (m6A) RNA modification impacts mRNA fate primarily via reader proteins, which dictate processes in development, stress, and disease. Yet little is known about m6A function in Saccharomyces cerevisiae, which occurs solely during ea
Externí odkaz:
https://doaj.org/article/1fdf12dea2744b80b90c259dff7abe55
Publikováno v:
Genome Biology, Vol 22, Iss 1, Pp 1-19 (2021)
Abstract Background Eukaryotic genomes undergo pervasive transcription, leading to the production of many types of stable and unstable RNAs. Transcription is not restricted to regions with annotated gene features but includes almost any genomic conte
Externí odkaz:
https://doaj.org/article/5dff81d4083f4964bb2b7fd2d7bc7b49
Autor:
Aleksandra Bliznina, Aki Masunaga, Michael J. Mansfield, Yongkai Tan, Andrew W. Liu, Charlotte West, Tanmay Rustagi, Hsiao-Chiao Chien, Saurabh Kumar, Julien Pichon, Charles Plessy, Nicholas M. Luscombe
Publikováno v:
BMC Genomics, Vol 22, Iss 1, Pp 1-18 (2021)
Abstract Background The larvacean Oikopleura dioica is an abundant tunicate plankton with the smallest (65–70 Mbp) non-parasitic, non-extremophile animal genome identified to date. Currently, there are two genomes available for the Bergen (OdB3) an
Externí odkaz:
https://doaj.org/article/6cbd2f5d71814f96a6432ac5d4289d27
Autor:
Lisa M. Strittmatter, Charlotte Capitanchik, Andrew J. Newman, Martina Hallegger, Christine M. Norman, Sebastian M. Fica, Chris Oubridge, Nicholas M. Luscombe, Jernej Ule, Kiyoshi Nagai
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
ATP-dependent helicases remodel the spliceosome and proofread splice site recognition. A new method – Purified Spliceosome iCLIP (psiCLIP) – probes protein-RNA interactions in defined spliceosome complexes to reveal how the helicases Prp16 and Pr
Externí odkaz:
https://doaj.org/article/0fcc6541964d40bfa8b86f4263c781c4
Autor:
Minghao Chia, Cai Li, Sueli Marques, Vicente Pelechano, Nicholas M. Luscombe, Folkert J. van Werven
Publikováno v:
Genome Biology, Vol 22, Iss 1, Pp 1-37 (2021)
Abstract Background The start and end sites of messenger RNAs (TSSs and TESs) are highly regulated, often in a cell-type-specific manner. Yet the contribution of transcript diversity in regulating gene expression remains largely elusive. We perform a
Externí odkaz:
https://doaj.org/article/257454bca56b4a35821c6634789b2745