Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Nicholas Lyons"'
Autor:
Sean M. Gross, Mark A. Dane, Rebecca L. Smith, Kaylyn L. Devlin, Ian C. McLean, Daniel S. Derrick, Caitlin E. Mills, Kartik Subramanian, Alexandra B. London, Denis Torre, John Erol Evangelista, Daniel J. B. Clarke, Zhuorui Xie, Cemal Erdem, Nicholas Lyons, Ted Natoli, Sarah Pessa, Xiaodong Lu, James Mullahoo, Jonathan Li, Miriam Adam, Brook Wassie, Moqing Liu, David F. Kilburn, Tiera A. Liby, Elmar Bucher, Crystal Sanchez-Aguila, Kenneth Daily, Larsson Omberg, Yunguan Wang, Connor Jacobson, Clarence Yapp, Mirra Chung, Dusica Vidovic, Yiling Lu, Stephan Schurer, Albert Lee, Ajay Pillai, Aravind Subramanian, Malvina Papanastasiou, Ernest Fraenkel, Heidi S. Feiler, Gordon B. Mills, Jake D. Jaffe, Avi Ma’ayan, Marc R. Birtwistle, Peter K. Sorger, James E. Korkola, Joe W. Gray, Laura M. Heiser
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-20 (2022)
Comprehensive profiling of ligand-induced perturbation responses of the MCF10A mammary epithelial cell line provides an exhaustive resource for identification of the molecular basis of cellular phenotypes.
Externí odkaz:
https://doaj.org/article/50400b000ed946209179e826cd85298c
Autor:
Shuang Zhang, Nicholas Lyons, Marijke Koedam, Jeroen van de Peppel, Johannes P.T.M. van Leeuwen, Bram C. J. van der Eerden
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
Several physiological and pathological conditions such as aging, obesity, diabetes, anorexia nervosa are associated with increased adipogenesis in the bone marrow. A lack of effective drugs hinder the improved treatment for aberrant accumulation of b
Externí odkaz:
https://doaj.org/article/2fa104be394e48ceb5bac3ab0764c218
Autor:
Tashbib Khan, Mitchell A. Sullivan, Jennifer H. Gunter, Thomas Kryza, Nicholas Lyons, Yaowu He, John D. Hooper
Publikováno v:
Frontiers in Oncology, Vol 10 (2020)
Once thought to be exclusively a storage hub for glucose, glycogen is now known to be essential in a range of physiological processes and pathological conditions. Glycogen lies at the nexus of diverse processes that promote malignancy, including prol
Externí odkaz:
https://doaj.org/article/5ee251c7b0914f95a69662f28d0c9995
Publikováno v:
Day 2 Tue, October 04, 2022.
Since the late 1970's, research on the efficiency and cutting life of polycrystalline diamond compact (PDC) cutters identified elevated temperature due to frictional heating as one of the primary accelerants of wear to the diamond cutting edge. Tempe
Publikováno v:
British Journal of Surgery. 109
Aims The ability to identify cancerous tissue intraoperatively has the potential to allow for real time identification of involved margins, lymph node involvement and extra-colonic deposits. Here we investigate whether antibodies targeting a novel re
Publikováno v:
British Journal of Surgery. 109
Aims EphA2 is a potential therapeutic target for the treatment of colorectal cancer (CRC), however reports of EphA2 expression in CRC are inconsistent and often lack the context of a normal tissue comparator. The aim of this investigation is to under
Autor:
Alison Griffin, Simon Puttick, Paul Thomas, T. Cuda, Vicki L. J. Whitehall, Jennifer Borowsky, Elizabeth Ahern, Cheng Liu, Andrew D. Riddell, David Wyld, John D. Hooper, Nicholas Lyons, Matthew Burge, David A. Clark, Stephen E. Rose, Andrew R. L. Stevenson
Publikováno v:
Journal of Nuclear Medicine. 61:1576-1579
At diagnosis, 22% of colorectal cancer (CRC) patients have metastases, and 50% later develop metastasis. Peptide receptor radionuclide therapy (PRRT), such as 177Lu-PSMA-617, is used to treat metastatic prostate cancer. 177Lu-PSMA-617 targets prostat
Autor:
Stephen E. Rose, Chao Li, Paul Thomas, James C. Whisstock, Kamil A. Sokolowski, Simon Puttick, T. Cuda, Elena I. Deryugina, James P. Quigley, Cameron Snell, David Wyld, Ashleigh Parkin, Tashbib Khan, Ruby H. P. Law, Thomas Kryza, Marina Pajic, Andrew D. Riddell, Brian W.C. Tse, Madeline Gough, Yaowu He, John D. Hooper, Nicholas Lyons, Andrew Barbour, Julia Yin
Publikováno v:
Theranostics
Background: CUB domain-containing protein 1 (CDCP1) is a cell surface receptor regulating key signalling pathways in malignant cells. CDCP1 has been proposed as a molecular target to abrogate oncogenic signalling pathways and specifically deliver ant
Autor:
Kamil A. Sokolowski, Simon Puttick, Cheng Liu, Madeline Gough, Brian W.C. Tse, T. Cuda, Yaowu He, Andrew R. L. Stevenson, Stephen E. Rose, Andrew D. Riddell, Cameron Snell, David A. Clark, Nicholas Lyons, Paul Thomas, Tashbib Khan, David Wyld, Thomas Kryza, John D. Hooper
Publikováno v:
Contrast Media & Molecular Imaging
Contrast Media & Molecular Imaging, Vol 2021 (2021)
Contrast Media & Molecular Imaging, Vol 2021 (2021)
Colorectal cancer (CRC) is the third most common malignancy in the world, with 22% of patients presenting with metastatic disease and a further 50% destined to develop metastasis. Molecular imaging uses antigen-specific ligands conjugated to radionuc
Autor:
Charlotte C. Williams, Simon Puttick, Nicholas Lyons, Lesley A. Pearce, Lewis Perrin, Thomas Hodgkinson, Tashbib Khan, Trent P. Munro, Sinead Barry, Michael D. Lee, Timothy E. Adams, C. Blake Gilks, Thomas Kryza, Rohan Lourie, Claire M. Davies, Yaowu He, Madeline Gough, John D. Hooper, Justin B. Goh, Martina L. Jones, Rebecca Rogers, Naven Chetty
Publikováno v:
Molecular pharmaceutics. 18(9)
Optimal cytoreduction for ovarian cancer is often challenging because of aggressive tumor biology and advanced stage. It is a critical issue since the extent of residual disease after surgery is the key predictor of ovarian cancer patient survival. F