Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Nicholas Luksha"'
Autor:
Martin J. Allen, Kirk Roffi, Danielle Meyer, Sandeep Kumar, Jeffrey Mitchell, David Cirelli, Dheeraj S. Tomar, Nicholas Luksha, Li Li
Publikováno v:
Protein Engineering, Design and Selection. 31:313-325
Developability considerations should be integrated with lead engineering of antibody drug candidates in interest of their cost effective translations into medicines. To explore feasibility of this imperative, we have performed rational mutagenesis st
Autor:
Li Li, Matthew P. Broulidakis, Christopher T Burns, Dheeraj S. Tomar, Nicholas Luksha, Sandeep Kumar, Satish K. Singh
Publikováno v:
mAbs. 9:476-489
Early stage developability assessments of monoclonal antibody (mAb) candidates can help reduce risks and costs associated with their product development. Forecasting viscosity of highly concentrated mAb solutions is an important aspect of such develo
Autor:
Patrick M. Buck, Satish K. Singh, Davin Boardman, Li Li, Nicholas Luksha, Nicholas W. Warne, Sandeep Kumar, Christopher J. Burns, Pilarin E. Nichols, Janelle Lavoie
Publikováno v:
Pharmaceutical Research. 31:3161-3178
Early identification of monoclonal antibody candidates whose development, as high concentration (≥100 mg/mL) drug products, could prove challenging, due to high viscosity, can help define strategies for candidate engineering and selection. Concentr