Výsledky vyhledávání - "Nicholas Larocque"

Using a Multi-Stage hESC Model to Characterize BDE-47 Toxicity During Neurogenesis

Autor: Charles J Fernandez, Helia Seifikar, Yvonne Kim, Joshua F. Robinson, Nicomedes Abello, Nicholas Larocque, Ibrahim Khatib, Hao Chen

Publikováno v: Toxicol Sci
Toxicological sciences : an official journal of the Society of Toxicology, vol 171, iss 1

Although the ramifications associated with polybrominated diphenyl ethers (PBDEs) exposures during human pregnancy have yet to be determined, increasing evidence in humans and animal models suggests that these compounds cause neurodevelopmental toxic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::231021fa08edff8e18c87433563e4ebf
https://doi.org/10.1093/toxsci/kfz136

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An Investigation of the Single and Combined Phthalate Metabolite Effects on Human Chorionic Gonadotropin Expression in Placental Cells

Autor: Ulf-Håkan Stenman, Ilpo Huhtaniemi, Mirhan Kapidzic, Yaqi Zhao, Nicholas Larocque, Hannu Koistinen, Lei V. Zhan, Jennifer J. Adibi

Publikováno v: Environmental Health Perspectives
Environmental health perspectives, vol 125, iss 10

Background: Observational studies have reported associations between maternal phthalate levels and adverse outcomes at birth and in the health of the child. Effects on placental function have been suggested as a biologic basis for these findings. Obj

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c554fd89d119456bce4791179e9f8048
http://europepmc.org/articles/PMC5933420

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Human stem cells from single blastomeres reveal pathways of embryonic or trophoblast fate specification

Publikováno v: Zdravkovic, Tamara; Nazor, Kristopher L; Larocque, Nicholas; Gormley, Matthew; Donne, Matthew; Hunkapillar, Nathan; et al.(2015). Human stem cells from single blastomeres reveal pathways of embryonic or trophoblast fate specification.. Development (Cambridge, England), 142(23), 4010-4025. doi: 10.1242/dev.122846. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/4kw1r5qj
Development (Cambridge, England), vol 142, iss 23
Development (Cambridge, England)

Mechanisms of initial cell fate decisions differ among species. To gain insights into lineage allocation in humans, we derived ten human embryonic stem cell lines (designated UCSFB1-10) from single blastomeres of four 8-cell embryos and one 12-cell e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff468bd92a9c5c6179421b35ddd1f965
http://www.escholarship.org/uc/item/4kw1r5qj

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Establishment of Human Trophoblast Progenitor Cell Lines from the Chorion

Autor: Mirhan Kapidzic, Gabriel Goldfien, Nicholas Larocque, Michael T. McMaster, Olga Genbacev, Matthew Gormley, Matthew Donne, Tamara Zdravkovic, Jacqueline Gilmore, Julie D. Lamb, Susan J. Fisher

Publikováno v: Stem Cells. 29:1427-1436

Placental trophoblasts are key determinants of in utero development. Mouse trophoblast (TB) stem cells, which were first derived over a decade ago, are a powerful cell culture model for studying their self-renewal or differentiation. Our attempts to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::002b81aafd62e5dcc47acbe5b816f3e7
https://doi.org/10.1002/stem.686

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Human embryonic stem cells as a model system for studying the effects of smoke exposure on the embryo

Autor: Michael T. McMaster, Olga Genbacev, Nicholas Larocque, Susan J. Fisher, Tamara Zdravkovic

Publikováno v: Reproductive Toxicology. 26:86-93

Human embryonic stem cells (hESCs) share many characteristics including pluripotency with cells of the early embryo and so are potentially useful tools for studying the harmful effects of xenobiotics during early development. Here, we used hESCs as a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13b58487f969747b0c0e28b40cee39f1
https://doi.org/10.1016/j.reprotox.2008.07.004

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Nuclear FAK Promotes Cell Proliferation and Survival through FERM-Enhanced p53 Degradation

Autor: Kyle Howerton, Ssang-Taek Lim, Dan A. Hanson, Yangmi Lim, Susan J. Fisher, Nicholas Larocque, Xiao Lei Chen, David D. Schlaepfer, Dusko Ilic, Thanh-Trang Vo

Publikováno v: Molecular Cell. 29:9-22

Summary FAK is known as an integrin- and growth factor-associated tyrosine kinase promoting cell motility. Here we show that, during mouse development, FAK inactivation results in p53- and p21-dependent mesodermal cell growth arrest. Reconstitution o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b899b2c5cb797248b25e3cd599eeb9c
https://doi.org/10.1016/j.molcel.2007.11.031

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Focal Adhesion Kinase Controls pH-Dependent Epidermal Barrier Homeostasis by Regulating Actin-Directed Na+/H+ Exchanger 1 Plasma Membrane Localization

Autor: Kenneth R. Feingold, Ossovskaya Valeria S, Dusko Ilic, Susan J. Fisher, Gregory Dolganov, Man Mao-Qiang, Peter M. Elias, Nicholas Larocque, Pu Xu, Debra Crumrine, David D. Schlaepfer, Barbara E. Brown, Ssang-Taek Lim, Theodora M. Mauro, Marianne Demerjian

Publikováno v: The American Journal of Pathology. 170:2055-2067

Ubiquitously expressed focal adhesion kinase (FAK), linked to multiple intracellular signaling pathways, has previously been shown to control cell motility, invasion, proliferation, and survival. Using mice with a keratinocyte-restricted deletion of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fdc594e59bc479537e586c74228a8f4
https://doi.org/10.2353/ajpath.2007.061277

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Hair cycle and wound healing in mice with a keratinocyte-restricted deletion of FAK

Autor: José L. Jorcano, Susan J. Fisher, S Essayem, Gregory Dolganov, Nicholas Larocque, Susan McDonagh, Angel Ramirez, Daniel M. Ramos, Dusko Ilic, Kyle Howerton, Theodora M. Mauro, Louis F. Reichardt, Hilary E. Beggs, Branka Kovacic-Milivojevic, Clark Baumbusch

Publikováno v: Oncogene. 25:1081-1089

Focal adhesion kinase (FAK) is a critical component in transducing signals downstream of both integrins and growth factor receptors. To determine how the loss of FAK affects the epidermis in vivo, we have generated a mouse model with a keratinocyte-r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::593d688d592d14084c1ed310dafd9e30
https://doi.org/10.1038/sj.onc.1209130

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