Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Nicholas L. Syn"'
Autor:
Benjamin Koh, Darren Jun Hao Tan, Wen Hui Lim, Jeffrey S L Wong, Cheng Han Ng, Kai En Chan, Meng Wang, Wei Peng Yong, Yock Young Dan, Louis Z Wang, Nigel Tan, Mark Muthiah, Alfred Kow, Nicholas L. Syn, Daniel Q. Huang, Thomas Yau
Publikováno v:
OncoImmunology, Vol 12, Iss 1 (2023)
ABSTRACTThe use of immune checkpoint inhibitors (ICIs) targeting PD-L1/PD-1 and CTLA-4 has transformed the oncology practice of hepatocellular carcinoma. However, only 25–30% of the patients with advanced HCC treated with atezolizumab-bevacizumab o
Externí odkaz:
https://doaj.org/article/98077533239642c291b0017f7ac49635
Autor:
Tira J. Tan, W. X. Gladys Ang, Who-Whong Wang, Hui-Shan Chong, Sze Huey Tan, Rachael Cheong, John Whay-Kuang Chia, Nicholas L. Syn, Wai Ho Shuen, Rebecca Ba, Nivashini Kaliaperumal, Bijin Au, Richard Hopkins, Xinhua Li, Aaron C. Tan, Amanda O. L. Seet, John E. Connolly, Thaschawee Arkachaisri, Valerie Chew, Ahmad bin Mohamed Lajam, Dianyan Guo, Marvin Z. W. Chew, Martin Wasser, Pavanish Kumar, Salvatore Albani, Han Chong Toh
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
Ad-sig-hMUC1/ecdCD40L is a recombinant adenovirus vaccine comprising human MUC1 antigen fused to the extracellular domain of the CD40 ligand. Here the authors report the result of a phase I clinical trial of Ad-sig-hMUC1/ecdCD40L in patients with adv
Externí odkaz:
https://doaj.org/article/bc9966f3f06642699fbd9cc02be4f7e3
Autor:
Nicole Li Xian Yap, Qianyi Kor, Yao Neng Teo, Yao Hao Teo, Nicholas L. Syn, Lauren Kay Mance Evangelista, Benjamin YQ. Tan, Weiqin Lin, Leonard LL. Yeo, William KF. Kong, Yao Feng Chong, Raymond CC. Wong, Kian Keong Poh, Tiong-Cheng Yeo, Vijay Kumar Sharma, Ping Chai, Mark Y. Chan, Fang Qin Goh, Ching-Hui Sia
Publikováno v:
Hellenic Journal of Cardiology, Vol 67, Iss , Pp 48-58 (2022)
Introduction: The burden of cognitive impairment in heart failure (HF) patients is significant and leads to longer hospital stay, higher readmission rates, and increased mortality. This review seeks to synthesize the available studies to determine th
Externí odkaz:
https://doaj.org/article/1124eebef0204526939ab820ede0165e
Autor:
Joseph J. Zhao, Nicholas L. Syn, Benjamin Kye Jyn Tan, Dominic Wei Ting Yap, Chong Boon Teo, Yiong Huak Chan, Raghav Sundar
Publikováno v:
BMC Medical Research Methodology, Vol 22, Iss 1, Pp 1-10 (2022)
Abstract Background Data from certain subgroups of clinical interest may not be presented in primary manuscripts or conference abstract presentations. In an effort to enable secondary data analyses, we propose a workflow to retrieve unreported subgro
Externí odkaz:
https://doaj.org/article/75e425d48078444aa57c647159a38bd5
Autor:
Ser Yue Loo, Nicholas L. Syn, Angele Pei-Fern Koh, Janet Cheng-Fei Teng, Amudha Deivasigamani, Tuan Zea Tan, Aye Aye Thike, Shireen Vali, Shweta Kapoor, Xiaoyuan Wang, Jiong Wei Wang, Puay Hoon Tan, George W. Yip, Gautam Sethi, Ruby Yun-Ju Huang, Kam Man Hui, Lingzhi Wang, Boon Cher Goh, Alan Prem Kumar
Publikováno v:
Cell Death Discovery, Vol 7, Iss 1, Pp 1-15 (2021)
Abstract Clinical trials repurposing peroxisome proliferator-activated receptor-gamma (PPARγ) agonists as anticancer agents have exhibited lackluster efficacy across a variety of tumor types. Here, we report that increased PPARG expression is associ
Externí odkaz:
https://doaj.org/article/82fb2ea92fce4d45b46ee3f019c45a37
Autor:
Joshua Y. P. Yeo, Claire X. Y. Goh, Ying Kiat Tan, Bryan T. S. Sim, Beverly L. X. Chan, Nicholas L. Syn, Yinghao Lim, Amanda C. Y. Chan, Vijay K. Sharma, Jonathan J. Y. Ong, Leonard L. L. Yeo, Ching-Hui Sia, Benjamin Y. Q. Tan
Publikováno v:
Frontiers in Neurology, Vol 13 (2022)
IntroductionWhite matter hyperintensities (WMHs) have been observed with greater frequency in patients with migraine and are thought to be associated with impaired cognition and function. The relationship between WMHs and right-to-left shunt (RLS) in
Externí odkaz:
https://doaj.org/article/2e114fbf45f8468aadcedb947b63b33c
Autor:
Lionel Chen, Nicholas L. Syn, Brian K. P. Goh, Peng Chung Cheow, Prema Raj, Yexin Koh, Alexander Chung, Ser Yee Lee, London Lucien Ooi, Chung Yip Chan, Jin Yao Teo
Publikováno v:
World Journal of Surgical Oncology, Vol 18, Iss 1, Pp 1-9 (2020)
Abstract Background Resection of colorectal liver metastases (CLM) has been established as the standard of care. This study aims to compare the change in clinicopathological characteristics of patients who underwent curative resection of CLM across t
Externí odkaz:
https://doaj.org/article/4fd6ff0600d649fab227054e01558fbb
Autor:
Joel Shi Quan Tan, Waikit Fung, Beverley Shu Wen Tan, Jia Ying Low, Nicholas L. Syn, Ying Xian Goh, Junxiong Pang
Publikováno v:
One Health, Vol 13, Iss , Pp 100343- (2021)
Introduction: The negative impact of the coronavirus disease 2019 (COVID-19) pandemic on mental health and physical activity is well reported. While prior studies showed a positive influence of pet ownership on physical activity and mental health, th
Externí odkaz:
https://doaj.org/article/a0d4155e6d834f1db171e01013addce1
Autor:
Li Ren Kong, Nur Afiqah Binte Mohamed Salleh, Richard Weijie Ong, Tuan Zea Tan, Nicholas L. Syn, Robby Miguel Goh, Chee Wai Fhu, Daniel S. W. Tan, N. Gopalakrishna Iyer, Srinivasaraghavan Kannan, Chandra S. Verma, Yaw Chyn Lim, Ross Soo, Jingshan Ho, Yiqing Huang, Joline S. J. Lim, Benedict Junrong Yan, Min En Nga, Seng Gee Lim, H. Phillip Koeffler, Soo Chin Lee, Dennis Kappei, Huynh The Hung, Boon Cher Goh
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
The MET receptor is frequently activated in cancer. Here, the authors show that in head and neck and lung squamous carcinoma, a polymorphic MET variant enhances binding to HER2, resulting in activation of HER2 signalling and progression of the cancer
Externí odkaz:
https://doaj.org/article/29d0a642abdc45549ef07f126485d155
Autor:
Sneha Rajiv Jain, Wilson Sim, Cheng Han Ng, Yip Han Chin, Wen Hui Lim, Nicholas L. Syn, Nur Haidah Bte Ahmad Kamal, Mehek Gupta, Valerie Heong, Xiao Wen Lee, Nur Sabrina Sapari, Xue Qing Koh, Zul Fazreen Adam Isa, Lucius Ho, Caitlin O’Hara, Arvindh Ulagapan, Shi Yu Gu, Kashyap Shroff, Rei Chern Weng, Joey S. Y. Lim, Diana Lim, Brendan Pang, Lai Kuan Ng, Andrea Wong, Ross Andrew Soo, Wei Peng Yong, Cheng Ean Chee, Soo-Chin Lee, Boon-Cher Goh, Richie Soong, David S.P. Tan
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
PurposePrecision oncology, such as next generation sequencing (NGS) molecular analysis and bioinformatics are used to guide targeted therapies. The laboratory turnaround time (TAT) is a key performance indicator of laboratory performance. This study
Externí odkaz:
https://doaj.org/article/480d74809a6444808db8f8d1fd0737bc