Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Nicholas L. Kovach"'
Autor:
Tsutomu Tsuji, Wilma Puzon-McLaughlin, Atsushi Irie, Xi Ping Zhang, Ken Ichi Takeuchi, Nicholas L. Kovach, Suzanne Laferté, Nicole L. Prokopishyn, Yoshikazu Takada
Publikováno v:
Biochemistry. 38:14424-14431
Integrin/ligand interaction is a therapeutic target for many diseases. We previously reported that residues critical for ligand binding are clustered in N-terminal repeat 3 (in the predicted 2-3 loop) of alpha 4, alpha 5 and alpha IIb. Here we have l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::719681931aca08d48221ccafed2aaf11
https://doi.org/10.1021/bi990323b
https://doi.org/10.1021/bi990323b
Autor:
Dana Strahl, Zhuang T. Fang, Mary C. Territo, Carlos Cabañas, Tatiana P. Ugarova, Devendra K. Vora, Joy S. Frank, Peggy T. Shih, Mariano J. Elices, Nicholas L. Kovach, Judith A. Berliner
Publikováno v:
Journal of Clinical Investigation. 103:613-625
We have shown previously that treatment of human aortic endothelial cells (HAECs) with minimally modified low-density lipoprotein (MM-LDL) induces monocyte but not neutrophil binding. This monocyte binding was not mediated by endothelial E-selectin,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd990a6a415f5352a2a6ababc42cfe39
https://doi.org/10.1172/jci5710
https://doi.org/10.1172/jci5710
Publikováno v:
Circulation Research. 79:310-316
Local alterations in the hemodynamic environment regulate endothelial cell function, but the signal-transduction mechanisms involved in this process remain unclear. We previously demonstrated that mitogen-activated protein (MAP) kinase is rapidly sti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b990ea23fe0a71d23572bba62022f26
https://doi.org/10.1161/01.res.79.2.310
https://doi.org/10.1161/01.res.79.2.310
Autor:
Alexander W. Clowes, John M. Harlan, Jiro Seki, Nicholas L. Kovach, Noriyuki Koyama, Ted Yednock
Publikováno v:
Circulation Research. 78:596-605
Abstract Avidity modulation and function of β 1 -integrin receptors in cultured human vascular smooth muscle cells (SMCs) were investigated using monoclonal antibody (mAb) 8A2, which binds to the β 1 subunit of integrin heterodimers and induces a h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::319b21652b6b12403da6294679ecd417
https://doi.org/10.1161/01.res.78.4.596
https://doi.org/10.1161/01.res.78.4.596
Publikováno v:
Blood. 87:2450-2458
Chronic myelogenous leukemia (CML) is a malignant disease of the hematopoietic stem cell characterized by abnormal circulation and proliferation of malignant progenitors. In contrast to their normal counterparts, CML progenitors adhere poorly to bone
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f1b460348d8320836373f3bc0774692
https://doi.org/10.1182/blood.v87.6.2450.bloodjournal8762450
https://doi.org/10.1182/blood.v87.6.2450.bloodjournal8762450
Publikováno v:
Journal of Biological Chemistry. 270:26232-26238
Osteopontin (OPN) is an extracellular matrix protein that binds to integrin αvβ3. Here we demonstrate that two other integrins, αvβ1 and αvβ5, are also receptors for OPN. Human embryonic kidney 293 cells adhere to human recombinant osteopontin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a11bc025f06cc332a6e525a51677e28a
https://doi.org/10.1074/jbc.270.44.26232
https://doi.org/10.1074/jbc.270.44.26232
Publikováno v:
Blood. 85:159-167
Interactions between hematopoietic cells and bone marrow (BM) stroma, composed of extracellular matrix and stromal cells, are crucial for hematopoiesis. Integrins facilitate these interactions by mediating adherence of hematopoiesis. Integrins facili
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b209d45a2ea5991c339c88e0721018cb
https://doi.org/10.1182/blood.v85.1.159.bloodjournal851159
https://doi.org/10.1182/blood.v85.1.159.bloodjournal851159
Autor:
Catherine G. Lindgren, Alexander Fefer, Ted Yednock, Nicholas L. Kovach, John A. Thompson, John M. Harlan
Publikováno v:
Blood. 84:2234-2242
Peripheral blood lymphocytes (PBLs) cultured in the presence of recombinant human interleukin-2 (rhIL-2) develop a natural killer (NK) cell phenotype (CD16+, CD56+, CD3-) and are referred to as lymphokine- activated killer cells (LAK). In developing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::32dc561fc8f71b076ea312a735cdad4f
https://doi.org/10.1182/blood.v84.7.2234.2234
https://doi.org/10.1182/blood.v84.7.2234.2234
Publikováno v:
Europe PubMed Central
Extracellular matrix receptors of the integrin family have a dual role in the epidermis, regulating both adhesion and differentiation. Loss of contact with the extracellular matrix causes keratinocytes to become committed to terminal differentiation,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53fd797190ca099e05d4fb39d39c0a6d
https://doi.org/10.1242/jcs.106.4.1131
https://doi.org/10.1242/jcs.106.4.1131
Publikováno v:
The Journal of Cell Biology
We report that a beta 1 integrin (alpha 5 beta 1) can exist in different affinity states for its soluble ligand, fibronectin. The alpha 5 beta 1 expressed by the erythroleukemic cell line K562 binds soluble fibronectin with low affinity (Kd > 1 micro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4fbf2be0cff257f6f6932db4b342772
https://doi.org/10.1083/jcb.121.1.155
https://doi.org/10.1083/jcb.121.1.155