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pro vyhledávání: '"Nicholas L. Cross"'
Autor:
Nicholas L. Cross
Publikováno v:
Biology of Reproduction. 71:1367-1373
Ejaculated mammalian sperm must complete a final maturation, termed capacitation, before they can undergo acrosomal exocytosis and fertilize an egg. In human sperm, loss of sperm sterol is an obligatory, early event in capacitation. How sterol loss l
Autor:
Nicholas L. Cross
Publikováno v:
Biology of Reproduction. 69:529-534
Ejaculated mammalian sperm must undergo a final maturation (capacitation) before they can acrosome-react and fertilize eggs. Loss of the sperm sterols, cholesterol and desmosterol, is an obligatory step in the capacitation of human sperm. Because ste
Autor:
Nicholas L. Cross, Matthew R. Nimmo
Publikováno v:
Biology of Reproduction. 68:1308-1317
Ejaculated mammalian sperm must undergo a final maturation (capacitation) before they can acrosome-react and fertilize eggs. Loss of cholesterol is an essential step in the capacitation of human sperm. Experimentally maintaining a high level of chole
Autor:
Nicholas L. Cross
Publikováno v:
Biology of Reproduction. 63:1129-1134
Ejaculated mammalian sperm must mature (capacitate) before they can undergo acrosomal exocytosis and fertilize an egg. Loss of sperm sterols is an early step in capacitation. Because sphingomyelin slows cholesterol efflux from other cells, the role o
Autor:
Nicholas L. Cross
Publikováno v:
Molecular Reproduction and Development. 53:92-98
Human sperm incubated in vitro gradually become capable of acrosome-reacting in response to the agonist, progesterone (P4). Loss of unesterified cholesterol is an obligatory step in the development of acrosomal responsiveness. These experiments teste
Autor:
Nicholas L. Cross
Publikováno v:
Biology of Reproduction. 59:7-11
Publikováno v:
Biology of Reproduction. 56:1169-1174
When incubated in vitro, human sperm gradually become capable of acrosome-reacting in response to the agonist progesterone. Loss of unesterified cholesterol is required for sperm to become responsive to progesterone, but how cholesterol regulates acr
Autor:
Nicholas L. Cross
Publikováno v:
Molecular Reproduction and Development. 45:212-217
Human sperm become responsive to inducers of the acrosome reaction when they are washed free of seminal plasma and incubated in an appropriate medium. Previous work has shown that cholesterol-enriched medium prevents sperm from becoming responsive to
Autor:
Renee J. Zarintash, Nicholas L. Cross
Publikováno v:
Biology of Reproduction. 55:19-24
Human sperm become responsive to inducers of the acrosome reaction if they are washed free of seminal plasma and incubated in an appropriate medium. We tested the hypothesis that sperm must lose cholesterol during incubation in order to become respon
Autor:
Stephen E. Hanks, Nicholas L. Cross
Publikováno v:
Human Reproduction. 6:1279-1283
Total acrosin activity and acrosomal status were determined before and after cryopreserving human spermatozoa. Three different cryopreservation protocols were used. Both acrosin activity and the incidence of intact acrosomes decreased during cryopres