Výsledky vyhledávání - "Nicholas L Taylor"

Disruption ofptLPD1orptLPD2, Genes That Encode Isoforms of the Plastidial Lipoamide Dehydrogenase, Confers Arsenate Hypersensitivity in Arabidopsis

Autor: Yingjun Chi, Hans Lambers, Patrick M. Finnegan, Nicholas L Taylor, Weihua Chen

Publikováno v: Plant Physiology. 153:1385-1397

Arsenic is a ubiquitous environmental poison that inhibits root elongation and seed germination to a variable extent depending on the plant species. To understand the molecular mechanisms of arsenic resistance, a genetic screen was developed to isola

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa37e732cd0a51b77e2f5c61f973a8c3
https://doi.org/10.1104/pp.110.153452

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Defining and maintaining a high quality screening collection: the GSK experience

Autor: Drake S. Eggleston, Nicholas L. Taylor, John C. Hollerton, Keith A. Brinded, Simon A. Readshaw, Stephen J. Lane

Publikováno v: Drug Discovery Today. 11:267-272

Understanding the quality of a screening collection is the first step to improving it and, as a result, the quality of the screening process. This article outlines how this issue was approached at GlaxoSmithKline and some of the hurdles that needed t

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https://doi.org/10.1016/s1359-6446(05)03730-x

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Toward Single-Calibrant Quantification in HPLC. A Comparison of Three Detection Strategies: Evaporative Light Scattering, Chemiluminescent Nitrogen, and Proton NMR

Autor: Zoe Blaxill, Bob Boughtflower, Duncan Farrant, Steve Lane, Ian Mutton, Nicholas L. Taylor, and Carol Carmody, Clare J. Paterson, Phil J. Borman

Publikováno v: Analytical Chemistry. 77:4354-4365

There is an urgent need for detection technologies that enable accurate and precise quantification of solutions containing small organic molecules in a manner that is rapid, cheap, non-labor-intensive, readily automated, and without a requirement for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82dd7244992353d31bdde170585db337
https://doi.org/10.1021/ac050257l

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Novel Inhibitors of Fungal Protein Synthesis Produced by a Strain of Graphium putredinis Isolation, Characterisation and Biological Properties

Autor: Philip J. Sidebottom, R. F. Middleton, Tracy C. Kennedy, Antony D. Buss, Oonagh S. Kinsman, Michael J. Dawson, Graham Webb, Richard J. P. Cannell, Nicholas L. Taylor

Publikováno v: Europe PubMed Central

The isolation and structure determination of 6 analogues of the fungal protein synthesis inhibitor GR135402, from Graphium putredinis, is described. The relative potencies of the compounds as protein synthesis inhibitors and as in vitro antifungal ag

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https://doi.org/10.7164/antibiotics.51.1012

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The design and use of a simple System Suitability Test Mix for generic reverse phase high performance liquid chromatography-mass spectrometry systems and the implications for automated system monitoring using global software tracking

Autor: Daniel Brooke, Bob Boughtflower, Nicholas L. Taylor, Ian Mutton

Publikováno v: Journal of chromatography. A. 1218(23)

The development of a seven-component test mixture designed for use with a generic gradient and a reversed-phase high performance liquid chromatography-mass spectrometry (RP-HPLC-MS) system is discussed. Unlike many test mixtures formulated in order t

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https://pubmed.ncbi.nlm.nih.gov/21543072

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The squalestatins, novel inhibitors of squalene synthase produced by a species of Phoma. IV. Preparation of fluorinated squalestatins by directed biosynthesis

Autor: Sean Lynn, Nicholas L. Taylor, Richard J. P. Cannell, Richard M. Hall, Richard S. Hale, David Noble, Michael J. Dawson

Publikováno v: Europe PubMed Central

Feeding of fluorinated benzoic acids to fermentations of a Phoma sp. resulted in the biosynthesis of a series of novel fluorinated squalestatins. The feeding studies, isolation, structural elucidation and biological activities of these compounds are

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https://doi.org/10.7164/antibiotics.46.1381

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ChemInform Abstract: Novel Squalestatins Produced by Biotransformation

Autor: Lawrence Gordon C, Nicholas L. Taylor, R. F. Middleton, Martin Todd, David Noble, Graham Foster, Richard J. P. Cannell, Michael J. Dawson, Philip J. Sidebottom

Publikováno v: ChemInform. 26

Microorganisms were screened for the ability to modify the squalene synthase inhibitor squalestatin 1. Biotransformation of 1 by two actinomycetes, SI5106 and SI5138, yielded three products hydroxylated on the 4, 6-dimethyl-oct-2-enoyl side chain eit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c4b45b27023c7f6bf40be302ac78255d
https://doi.org/10.1002/chin.199541266

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ChemInform Abstract: Eryloside F, a Novel Penasterol Disaccharide Possessing Potent Thrombin Receptor Antagonist Activity

Autor: Philip J. Sidebottom, Paul Stead, Amy E. Wright, David Langley, Nicholas L. Taylor, Phil S. Robinson, Stephen Edward Hiscox, Andrew D. Roberts, Shirley A. Pomponi, Nicholas B. Pike

Publikováno v: ChemInform. 31

We report the discovery of Eryloside F, a novel disaccharide of the steroidal carboxylic acid penasterol, isolated from an extract of the marine sponge Erylus formosus. The compound is a potent thrombin receptor antagonist, and furthermore inhibits h

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https://doi.org/10.1002/chin.200028205

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