Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Nicholas L Denton"'
Autor:
Gregory K Friedman, Elizabeth A Beierle, George Yancey Gillespie, James M Markert, Alicia M Waters, Chun-Yu Chen, Nicholas L Denton, Kellie B Haworth, Brian Hutzen, Jennifer L Leddon, Keri A Streby, Pin-Yi Wang, Timothy P Cripe
Publikováno v:
Molecular Therapy: Oncolytics, Vol 2, Iss , Pp - (2015)
Oncolytic engineered herpes simplex viruses (HSVs) possess many biologic and functional attributes that support their use in clinical trials in children with solid tumors. Tumor cells, in an effort to escape regulatory mechanisms that would impair th
Externí odkaz:
https://doaj.org/article/208f8509998642acba0b4dae3437f353
Autor:
Timothy P Cripe, Chun-Yu Chen, Nicholas L Denton, Kellie B Haworth, Brian Hutzen, Jennifer L Leddon, Keri A Streby, Pin-Yi Wang, James M Markert, Alicia M Waters, George Yancey Gillespie, Elizabeth A Beierle, Gregory K Friedman
Publikováno v:
Molecular Therapy: Oncolytics, Vol 2, Iss , Pp - (2015)
Progress for improving outcomes in pediatric patients with solid tumors remains slow. In addition, currently available therapies are fraught with numerous side effects, often causing significant life-long morbidity for long-term survivors. The use of
Externí odkaz:
https://doaj.org/article/043d5f96330c4eb88f47cb78076352d8
Autor:
Jennifer L Leddon, Chun-Yu Chen, Mark A Currier, Pin-Yi Wang, Francesca A Jung, Nicholas L Denton, Kevin M Cripe, Kellie B Haworth, Michael A Arnold, Amy C Gross, Timothy D Eubank, William F Goins, Joseph C Glorioso, Justus B Cohen, Paola Grandi, David A Hildeman, Timothy P Cripe
Publikováno v:
Molecular Therapy: Oncolytics, Vol 1, Iss C (2014)
Multiple studies have indicated that in addition to direct oncolysis, virotherapy promotes an antitumor cytotoxic T cell response important for efficacy. To study this phenomenon further, we tested three syngeneic murine sarcoma models that displayed
Externí odkaz:
https://doaj.org/article/bf8e7d0411ef44b882998c44c0e17aa8
Publikováno v:
Paediatric Drugs
Cancer immunotherapies, widely heralded as transformational for many adult cancer patients, are becoming viable options for selected subsets of pediatric cancer patients. Many therapies are currently being investigated, from immunomodulatory agents t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f57d81391c796a71ff701a3292d0188b
https://pubmed.ncbi.nlm.nih.gov/29948928
https://pubmed.ncbi.nlm.nih.gov/29948928
Autor:
Sherry Thornton, Balveen Kaur, Haritha Mathsyaraja, Zhengtao Chu, Tristan Bourdeau, Mary B. Palascak, Nicholas L Denton, Michael C. Ostrowski, Chang-Hyuk Kwon, Jeffrey Wojton, Lionel M.L. Chow, Walter Hans Meisen, Robert S. Franco, Xiaoyang Qi
Publikováno v:
Molecular Therapy. 21:1517-1525
Saposin C-dioleoylphosphatidylserine (SapC-DOPS) nanovesicles are a nanotherapeutic which effectively target and destroy cancer cells. Here, we explore the systemic use of SapC-DOPS in several models of brain cancer, including glioblastoma multiforme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9053492e735fc368a0242f4bad9ec64
https://doi.org/10.1038/mt.2013.114
https://doi.org/10.1038/mt.2013.114
Publikováno v:
Biomedicines
Biomedicines, Vol 4, Iss 3, p 13 (2016)
Biomedicines, Vol 4, Iss 3, p 13 (2016)
Cancer therapy remains a challenge due to toxicity limitations of chemotherapy and radiation therapy. Oncolytic viruses that selectively replicate and destroy cancer cells are of increasing interest. In addition to direct cell lysis, these vectors st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::877acc9b1189dd3865419a314c1b737c
http://europepmc.org/articles/PMC5344259
http://europepmc.org/articles/PMC5344259
Autor:
Jennifer L. Leddon, George Yancey Gillespie, Brian Hutzen, Pin-Yi Wang, Alicia M. Waters, Elizabeth A. Beierle, James M. Markert, Chun-Yu Chen, Nicholas L Denton, Timothy P. Cripe, Gregory K. Friedman, Keri A. Streby, Kellie B. Haworth
Publikováno v:
Molecular Therapy Oncolytics
Molecular Therapy: Oncolytics, Vol 2, Iss, Pp-(2015)
Molecular Therapy: Oncolytics, Vol 2, Iss, Pp-(2015)
Progress for improving outcomes in pediatric patients with solid tumors remains slow. In addition, currently available therapies are fraught with numerous side effects, often causing significant life-long morbidity for long-term survivors. The use of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::658dba0eaec29be2c2412a3b27534bfa
Autor:
Balveen Kaur, Zhengtao Chu, Amy Haseley Thorne, Jeffrey Wojton, Naduparambil K. Jacob, Jayson Hardcastle, Rachel L. Marsh, Erwin G. Van Meir, Xiaoyang Qi, Walter Hans Meisen, Arnab Chakravarti, Nina Dmitrieva, Chang-Hyuk Kwon, Nicholas L Denton
Publikováno v:
Oncotarget
SapC-DOPS is a novel nanotherapeutic that has been shown to target and induce cell death in a variety of cancers, including glioblastoma (GBM). GBM is a primary brain tumor known to frequently demonstrate resistance to apoptosis-inducing therapeutics
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c56503f49d7354900696ef8bdd145744
https://pubmed.ncbi.nlm.nih.gov/25210852
https://pubmed.ncbi.nlm.nih.gov/25210852
Autor:
Pin-Yi Wang, Chun-Yu Chen, Brian Hutzen, Tim D. Eubank, Jennifer L. Leddon, Nicholas L Denton, Timothy P. Cripe, Mark A. Currier
Publikováno v:
Cancer Immunology Research. 3:B66-B66
Ewing's Sarcoma (EWS) is the second most common childhood bone cancer with high rate of metastasis (25%) and tumor recurrence (30~40%). Despite tremendous advances in the five-year survival rate of localized disease (70~80%), overall survival for pat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4965b75d068ba72125e0d2dae011923b
https://doi.org/10.1158/2326-6074.tumimm14-b66
https://doi.org/10.1158/2326-6074.tumimm14-b66
Autor:
Alicia M. Waters, George Yancey Gillespie, James M. Markert, Chun-Yu Chen, Gregory K. Friedman, Pin-Yi Wang, Keri A. Streby, Jennifer L. Leddon, Nicholas L Denton, Timothy P. Cripe, Kellie B. Haworth, Brian Hutzen, Elizabeth A. Beierle
Publikováno v:
Molecular Therapy: Oncolytics, Vol 2, Iss, Pp-(2015)
Molecular Therapy Oncolytics
Molecular Therapy Oncolytics
Oncolytic engineered herpes simplex viruses (HSVs) possess many biologic and functional attributes that support their use in clinical trials in children with solid tumors. Tumor cells, in an effort to escape regulatory mechanisms that would impair th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2d673edb80d2edc6936167e53440674
https://doi.org/10.1038/mto.2015.16
https://doi.org/10.1038/mto.2015.16