A novel immunomodulating peptide with potential to complement oligodeoxynucleotide-mediated adjuvanticity in vaccination strategies

Autor: Michael Agrez, Christopher Chandler, Kristofer J. Thurecht, Nicholas L. Fletcher, Feifei Liu, Gayathri Subramaniam, Christopher B. Howard, Stephen Parker, Darryl Turner, Justyna Rzepecka, Gavin Knox, Anastasia Nika, Andrew M. Hall, Hayley Gooding, Laura Gallagher

Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-17 (2024)

Abstract The identification of adjuvants to improve vaccination efficacy is a major unmet need. One approach is to augment the functionality of dendritic cells (DCs) by using Toll-like receptor-9 (TLR9) agonists such as cytosine-phosphate-guanine oli

Externí odkaz: https://doaj.org/article/7a51c439ab39409a885cbdbbf60e0eef

Understanding hospital rehabilitation using electronic health records in patients with and without COVID-19

Autor: Konstantin Georgiev, Dimitrios Doudesis, Joanne McPeake, Nicholas L Mills, Jacques Fleuriot, Susan D Shenkin, Atul Anand

Publikováno v: BMC Health Services Research, Vol 24, Iss 1, Pp 1-10 (2024)

Abstract Background Many hospitalised patients require rehabilitation during recovery from acute illness. We use routine data from Electronic Health Records (EHR) to report the quantity and intensity of rehabilitation required to achieve hospital dis

Externí odkaz: https://doaj.org/article/b1d7ffc4fee340498cc6574f97f82ab9

Mammals show faster recovery from capture and tagging in human-disturbed landscapes

Autor: Jonas Stiegler, Cara A. Gallagher, Robert Hering, Thomas Müller, Marlee Tucker, Marco Apollonio, Janosch Arnold, Nancy A. Barker, Leon Barthel, Bruno Bassano, Floris M. van Beest, Jerrold L. Belant, Anne Berger, Dean E. Beyer Jr, Laura R. Bidner, Stephen Blake, Konstantin Börner, Francesca Brivio, Rudy Brogi, Bayarbaatar Buuveibaatar, Francesca Cagnacci, Jasja Dekker, Jane Dentinger, Martin Duľa, Jarred F. Duquette, Jana A. Eccard, Meaghan N. Evans, Adam W. Ferguson, Claudia Fichtel, Adam T. Ford, Nicholas L. Fowler, Benedikt Gehr, Wayne M. Getz, Jacob R. Goheen, Benoit Goossens, Stefano Grignolio, Lars Haugaard, Morgan Hauptfleisch, Morten Heim, Marco Heurich, Mark A. J. Hewison, Lynne A. Isbell, René Janssen, Anders Jarnemo, Florian Jeltsch, Jezek Miloš, Petra Kaczensky, Tomasz Kamiński, Peter Kappeler, Katharina Kasper, Todd M. Kautz, Sophia Kimmig, Petter Kjellander, Rafał Kowalczyk, Stephanie Kramer-Schadt, Max Kröschel, Anette Krop-Benesch, Peter Linderoth, Christoph Lobas, Peter Lokeny, Mia-Lana Lührs, Stephanie S. Matsushima, Molly M. McDonough, Jörg Melzheimer, Nicolas Morellet, Dedan K. Ngatia, Leopold Obermair, Kirk A. Olson, Kidan C. Patanant, John C. Payne, Tyler R. Petroelje, Manuel Pina, Josep Piqué, Joseph Premier, Jan Pufelski, Lennart Pyritz, Maurizio Ramanzin, Manuel Roeleke, Christer M. Rolandsen, Sonia Saïd, Robin Sandfort, Krzysztof Schmidt, Niels M. Schmidt, Carolin Scholz, Nadine Schubert, Nuria Selva, Agnieszka Sergiel, Laurel E. K. Serieys, Václav Silovský, Rob Slotow, Leif Sönnichsen, Erling J. Solberg, Mikkel Stelvig, Garrett M. Street, Peter Sunde, Nathan J. Svoboda, Maria Thaker, Maxi Tomowski, Wiebke Ullmann, Abi T. Vanak, Bettina Wachter, Stephen L. Webb, Christopher C. Wilmers, Filip Zieba, Tomasz Zwijacz-Kozica, Niels Blaum

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)

Abstract Wildlife tagging provides critical insights into animal movement ecology, physiology, and behavior amid global ecosystem changes. However, the stress induced by capture, handling, and tagging can impact post-release locomotion and activity a

Externí odkaz: https://doaj.org/article/8a567bd4bfa54bc6bfe6f85c5511ead1

A multiplexed high throughput screening assay using flow cytometry identifies glycolytic molecular probes in bloodstream form Trypanosoma brucei

Autor: Daniel H. Call, John Asafo Adjei, Ryan Pilgrim, James W. Jeong, E. Vance Willis, Ronald A. Zegarra, Nicholas L. Tapia, Madalyn Osterhaus, Jacob A. Vance, Charles M. Voyton, James A. Call, Sabrina S. Pizarro, James C. Morris, Kenneth A. Christensen

Publikováno v: International Journal for Parasitology: Drugs and Drug Resistance, Vol 26, Iss , Pp 100557- (2024)

Kinetoplastid organisms, including Trypanosoma brucei, are a significant health burden in many tropical and semitropical countries. Much of their metabolism is poorly understood. To better study kinetoplastid metabolism, chemical probes that inhibit

Externí odkaz: https://doaj.org/article/e34558ac362a47d9bc034f7935e262a8

External validation of the Leiden Thrombosis Recurrence Risk Prediction models (L-TRRiP) for the prediction of recurrence after a first venous thrombosis in the Heart and Vascular Health study

Autor: J. Louise I. Burggraaf-van Delft, Kerri L. Wiggins, Nienke van Rein, Saskia le Cessie, Nicholas L. Smith, Suzanne C. Cannegieter

Publikováno v: Research and Practice in Thrombosis and Haemostasis, Vol 8, Iss 8, Pp 102610- (2024)

Background: Long-term outcome after a first venous thromboembolism (VTE) might be optimized by tailoring anticoagulant treatment duration on individual risks of recurrence and major bleeding. The L-TRRiP models (A–D) were previously developed in da

Externí odkaz: https://doaj.org/article/e409c72586b941c3ba1f401efc751719