Zobrazeno 1 - 10
of 90
pro vyhledávání: '"Nicholas Kwiatkowski"'
Autor:
Yang Gao, Marina Volegova, Nicole Nasholm, Sanjukta Das, Nicholas Kwiatkowski, Brian J. Abraham, Tinghu Zhang, Nathanael S. Gray, Clay Gustafson, Malgorzata Krajewska, Rani E. George
Publikováno v:
Frontiers in Oncology, Vol 11 (2022)
PurposeCyclin-dependent kinases (CDKs) that have critical roles in RNA polymerase II (Pol II)-mediated gene transcription are emerging as therapeutic targets in cancer. We have previously shown that THZ1, a covalent inhibitor of CDKs 7/12/13, leads t
Externí odkaz:
https://doaj.org/article/b2450fd55dbf407997b81e9467e081a4
Autor:
Malgorzata Krajewska, Ruben Dries, Andrew V. Grassetti, Sofia Dust, Yang Gao, Hao Huang, Bandana Sharma, Daniel S. Day, Nicholas Kwiatkowski, Monica Pomaville, Oliver Dodd, Edmond Chipumuro, Tinghu Zhang, Arno L. Greenleaf, Guo-Cheng Yuan, Nathanael S. Gray, Richard A. Young, Matthias Geyer, Scott A. Gerber, Rani E. George
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Cdk12 is primarily involved in the regulation of DNA damage response (DDR) gene transcription as well as mRNA processing. Here, the authors demonstrate that CDK12 suppresses intronic polyadenylation, and that inhibition of this kinase primarily affec
Externí odkaz:
https://doaj.org/article/fedbb8762827499baca37a345fd99c5e
Autor:
Sampada Kalan, Ramon Amat, Miriam Merzel Schachter, Nicholas Kwiatkowski, Brian J. Abraham, Yanke Liang, Tinghu Zhang, Calla M. Olson, Stéphane Larochelle, Richard A. Young, Nathanael S. Gray, Robert P. Fisher
Publikováno v:
Cell Reports, Vol 21, Iss 2, Pp 467-481 (2017)
Summary: Cdk7, the CDK-activating kinase and transcription factor IIH component, is a target of inhibitors that kill cancer cells by exploiting tumor-specific transcriptional dependencies. However, whereas selective inhibition of analog-sensitive (AS
Externí odkaz:
https://doaj.org/article/6e79333bb0bb44d39aacfbac77a291d1
Autor:
Brian J. Abraham, Denes Hnisz, Abraham S. Weintraub, Nicholas Kwiatkowski, Charles H. Li, Zhaodong Li, Nina Weichert-Leahey, Sunniyat Rahman, Yu Liu, Julia Etchin, Benshang Li, Shuhong Shen, Tong Ihn Lee, Jinghui Zhang, A. Thomas Look, Marc R. Mansour, Richard A. Young
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Sequencing initiatives have detected multiple types of mutations in cancer. Here the authors, analysing enhancer-targeting sequence data, show that small insertions in transcriptional enhancers are frequently found near oncogenes, and demonstrate how
Externí odkaz:
https://doaj.org/article/83aabc930e7b4c009b32aff780ab64f2
Autor:
Florencia Cayrol, Pannee Praditsuktavorn, Tharu M. Fernando, Nicholas Kwiatkowski, Rosella Marullo, M. Nieves Calvo-Vidal, Jude Phillip, Benet Pera, Shao Ning Yang, Kaipol Takpradit, Lidia Roman, Marcello Gaudiano, Ramona Crescenzo, Jia Ruan, Giorgio Inghirami, Tinghu Zhang, Graciela Cremaschi, Nathanael S. Gray, Leandro Cerchietti
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
T-cell lymphomas are aggressive diseases associated with poor outcome. Here, the authors show that the THZ1, a CDK7 inhibitor, suppresses STAT transcriptional activity leading to apoptosis and sensitization to BCL2 inhibitors in T-cell lymphomas.
Externí odkaz:
https://doaj.org/article/d9b0eca4497a40c1b2e964a28298864d
Autor:
Brian J. Abraham, Denes Hnisz, Abraham S. Weintraub, Nicholas Kwiatkowski, Charles H. Li, Zhaodong Li, Nina Weichert-Leahey, Sunniyat Rahman, Yu Liu, Julia Etchin, Benshang Li, Shuhong Shen, Tong Ihn Lee, Jinghui Zhang, A. Thomas Look, Marc R. Mansour, Richard A. Young
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-1 (2017)
Nature Communications 8: Article number:14385 (2017); Published: 9 February 2017; Updated: 1 June 2017 In the original version of Supplementary Data 1 associated with this Article, the list of predicted enhancer-associated insertions was inadvertentl
Externí odkaz:
https://doaj.org/article/a5144bbffd064084a1cb968c0fb0bb7e
Autor:
Florencia Cayrol, Pannee Praditsuktavorn, Tharu M. Fernando, Nicholas Kwiatkowski, Rossella Marullo, M. Nieves Calvo-Vidal, Jude Phillip, Benet Pera, Shao Ning Yang, Kaipol Takpradit, Lidia Roman, Marcello Gaudiano, Ramona Crescenzo, Jia Ruan, Giorgio Inghirami, Tinghu Zhang, Graciela Cremaschi, Nathanael S Gray, Leandro Cerchietti
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-1 (2017)
Nature Communications 8: Article number: 14290 (2017); Published: 30 January 2017; Updated: 20 February 2017 The original version of this Article contained an error in the spelling of the author Rossella Marullo, which was incorrectly given as Rosell
Externí odkaz:
https://doaj.org/article/4f6d287b1b314c20bd2687a9811a5e95
Autor:
Wenchao Lu, Mengyang Fan, Wenzhi Ji, Jason Tse, Inchul You, Scott B. Ficarro, Isidoro Tavares, Jianwei Che, Audrey Y. Kim, Xijun Zhu, Andrew Boghossian, Matthew G. Rees, Melissa M. Ronan, Jennifer A. Roth, Stephen M. Hinshaw, Behnam Nabet, Steven M. Corsello, Nicholas Kwiatkowski, Jarrod A. Marto, Tinghu Zhang, Nathanael S. Gray
Publikováno v:
J Med Chem
Transcriptional enhanced associate domain (TEAD) proteins together with their transcriptional coactivator yes-associated protein (YAP) and transcriptional coactivator with the PDZ-binding motif (TAZ) are important transcription factors and cofactors
Autor:
Peter S. Hammerman, Kwok-Kin Wong, Richard A. Young, Nathanael S. Gray, Hideo Watanabe, Adam J. Bass, Matthew Meyerson, Takeshi Shimamura, Li Tan, Tenny Mudianto, Michael Silkes, Neermala Poudel-Neupane, Sook-Hee Hong, Tae-Jung Kim, Tinghu Zhang, Yichen Wang, Tianxia Li, Alan L. Leggett, Tiffany Tavares, Hideki Terai, Wankun Chen, Haikuo Zhang, Kevin Rhee, Shuai Li, Ting Chen, Bruno Bockorny, Kevin A. Buczkowski, Nicholas Kwiatkowski, Brian J. Abraham, Camilla L. Christensen, Yvonne Li, Kapsok Li, Maria Rusan
Supplementary Figures 1-10 and corresponding legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79dc8837ec3b000f674813205736cf1c
https://doi.org/10.1158/2159-8290.22533643
https://doi.org/10.1158/2159-8290.22533643
Autor:
David A. Barbie, Peter S. Hammerman, Anthony Letai, Teppei Shimamura, Kwok-Kin Wong, Eric S. Fischer, Nathanael S. Gray, Guo Wei, Kunihiko Hinohara, Nicholas Kwiatkowski, Katherine A. Donovan, Federica Piccioni, Tran C. Thai, Maria Rusan, Tae-jung Kim, Ting Chen, Laura Gutierrez Quiceno, Yusuke Matsui, Danielle S. Potter, Shunsuke Kitajima, Hideki Terai
Sequence of qPCR primers and sgRNAs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc660c2a32c94a3117033ab92dee6cf8
https://doi.org/10.1158/0008-5472.22418007.v1
https://doi.org/10.1158/0008-5472.22418007.v1