Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Nicholas Koylass"'
Autor:
Jessica Elmore, Chavez Carter, Amie Redko, Nicholas Koylass, Amelia Bennett, Max Mead, Marinel Ocasio-Rivera, Weishan Huang, Ankur Singh, Avery August
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-11 (2022)
The kinase Itk is normally required for differentiation of IL-17-producing CD4 T-helper (Th)17 cells however, Elmore, Carter et al. now report that Itk can be bypassed during Th17 differentiation in Saccharopolyspora rectivirgula induced hypersensiti
Externí odkaz:
https://doaj.org/article/f149f6e20ad24cd3b72863321fe8bbe9
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
IL-10+Tr1 cells, which do not express stable Foxp3 like conventional Treg cells, are associated with various diseases, but little is known about how their differentiation and function are regulated. Here the authors show that ITK is a central TCR sig
Externí odkaz:
https://doaj.org/article/eb63136b19fd40fbb0f60255832a0ecd
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-1 (2020)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Externí odkaz:
https://doaj.org/article/0a99219c27144071be43a613a3655986
Autor:
Jiachen Chu, Junhua Yang, Yuan Zhou, Jianan Chen, Kevin Hong Chen, Chi Zhang, Henry Yi Cheng, Nicholas Koylass, Jun O. Liu, Yun Guan, Zhaozhu Qiu
Publikováno v:
bioRxiv
Following peripheral nerve injury, extracellular ATP-mediated purinergic signaling is crucial for spinal cord microglia activation and neuropathic pain. However, the mechanisms of ATP release remain poorly understood. Here, we show that volume-regula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d3b820f8449483506ddd84f96389ba3
https://europepmc.org/articles/PMC9881986/
https://europepmc.org/articles/PMC9881986/
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-1 (2020)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Nature Communications
Nature Communications
Type 1 regulatory T (Tr1) cells differentiate in response to signals engaging the T cell receptor (TCR), express high levels of the immunosuppressive cytokine IL-10, but not Foxp3, and can suppress inflammation and promote immune tolerance. Here we s
Autor:
Jessica Elmore, Chavez Carter, Nicholas Koylass, Amelia Bennett, Max Mead, Alexia Kim, Weishan Huang, Avery August
Publikováno v:
The Journal of Immunology. 204:147.9-147.9
The balance of inflammatory and suppressive cytokines is critical in controlling inflammatory responses, and the pro- and anti-inflammatory cytokines IL17A and IL10 has been implicated in numerous pulmonary inflammatory diseases. The tyrosine kinase,
Autor:
Judith A. Appleton, Arun Kannan, Avery August, Sonia Mohinta, Nicholas Koylass, Weishan Huang, Lu Huang
Publikováno v:
Scientific Reports
Th1, Th2, Th9 and Th17 cells are conventional CD4+ effector T cells identified as secretors of prototypical cytokines IFNγ, IL4, IL9, and IL-17A respectively. Recently, populations of natural Th17 and Th1 cells (nTh17 and nTh1) with innate-like phen
Publikováno v:
The Journal of Immunology. 198:53.18-53.18
The tyrosine kinase, Itk, plays a critical role in T cell receptor signaling, and we have previously shown that Itk is required for the development of Th17 cells and their production of the pro-inflammatory cytokine IL17A. IL17A has been implicated i
Publikováno v:
The Journal of Immunology. 196:133.36-133.36
Type 1 regulatory T (Tr1)cells lack the expression of Foxp3 but are potent producers of the immunosuppressive cytokine IL-10, with profound regulatory function in suppressing inflammation and promoting tolerance. Tr1 cells differentiate in response t