Zobrazeno 1 - 10
of 194
pro vyhledávání: '"Nicholas Kim"'
Autor:
Nicholas Kim-Wah Yeo, Che Kang Lim, Katherine Nay Yaung, Nicholas Kim Huat Khoo, Thaschawee Arkachaisri, Salvatore Albani, Joo Guan Yeo
Publikováno v:
Frontiers in Genetics, Vol 15 (2024)
Early-onset systemic lupus erythematosus presents with a more severe disease and is associated with a greater genetic burden, especially in patients from Black, Asian or Hispanic ancestries. Next-generation sequencing techniques, notably whole exome
Externí odkaz:
https://doaj.org/article/d21ed98fec9f4c5290a67e6960831c53
Autor:
Laurent Renia, Yun Shan Goh, Angeline Rouers, Nina Le Bert, Wan Ni Chia, Jean-Marc Chavatte, Siew‐Wai Fong, Zi Wei Chang, Nicole Ziyi Zhuo, Matthew Zirui Tay, Yi-Hao Chan, Chee Wah Tan, Nicholas Kim‐Wah Yeo, Siti Naqiah Amrun, Yuling Huang, Joel Xu En Wong, Pei Xiang Hor, Chiew Yee Loh, Bei Wang, Eve Zi Xian Ngoh, Siti Nazihah Mohd Salleh, Guillaume Carissimo, Samanzer Dowla, Alicia Jieling Lim, Jinyan Zhang, Joey Ming Er Lim, Cheng-I. Wang, Ying Ding, Surinder Pada, Louisa Jin Sun, Jyoti Somani, Eng Sing Lee, Desmond Luan Seng Ong, SCOPE Cohort Study Group, Yee‐Sin Leo, Paul A. MacAry, Raymond Tzer Pin Lin, Lin-Fa Wang, Ee Chee Ren, David C. Lye, Antonio Bertoletti, Barnaby Edward Young, Lisa F. P. Ng
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Responses to SARS-CoV-2 vaccines in different populations are important to define efficacy. Here the authors show using a cohort in Singapore that two doses of mRNA vaccine is less effective in recipients over 60 years of age and that a further dose
Externí odkaz:
https://doaj.org/article/f557f150209f4990850aaa97c4f0f4e6
Autor:
Zi Wei Chang, Yun Shan Goh, Angeline Rouers, Siew-Wai Fong, Matthew Zirui Tay, Jean-Marc Chavatte, Pei Xiang Hor, Chiew Yee Loh, Yuling Huang, Yong Jie Tan, Vanessa Neo, Isaac Kai Jie Kam, Nicholas Kim-Wah Yeo, Eunice X. Tan, Daniel Huang, Bei Wang, Siti Nazihah Mohd Salleh, Eve Zi Xian Ngoh, Cheng-I. Wang, Yee-Sin Leo, Raymond Tzer Pin Lin, David Chien Boon Lye, Barnaby Edward Young, Mark Muthiah, Lisa F. P. Ng, Laurent Rénia, COVID-19 Study Group
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Vaccine immunogenicity in transplant recipients can be impacted by the immunosuppressive (IS) regimens they receive. While BNT162b2 vaccination has been shown to induce an immune response in liver transplant recipients (LTRs), it remains unclear how
Externí odkaz:
https://doaj.org/article/f3d52a89fbb1447281fee1def1b32d2a
Autor:
Shengjie Xu, Anthony Schwab, Nikhil Karmacharya, Gaoyuan Cao, Joanna Woo, Nicholas Kim, Steven S. An, Reynold A. Panettieri Jr, Joseph A. Jude
Publikováno v:
Respiratory Research, Vol 21, Iss 1, Pp 1-10 (2020)
Abstract Background Activation of free fatty acid receptors (FFAR1 and FFAR4) which are G protein-coupled receptors (GPCRs) with established (patho)physiological roles in a variety of obesity-related disorders, induce human airway smooth muscle (HASM
Externí odkaz:
https://doaj.org/article/0d19388550394064a4134701d05d7fee
Autor:
Emilie Heckel, Gael Cagnone, Tapan Agnihotri, Bertan Cakir, Ashim Das, Jin Sung Kim, Nicholas Kim, Geneviève Lavoie, Anu Situ, Sheetal Pundir, Ye Sun, Florian Wünnemann, Kerry A. Pierce, Courtney Dennis, Grant A. Mitchell, Sylvain Chemtob, Flavio A. Rezende, Gregor Andelfinger, Clary B. Clish, Philippe P. Roux, Przemyslaw Sapieha, Lois E.H. Smith, Jean-Sébastien Joyal
Publikováno v:
JCI Insight, Vol 7, Iss 6 (2022)
Dyslipidemia and autophagy have been implicated in the pathogenesis of blinding neovascular age-related macular degeneration (NV-AMD). VLDL receptor (VLDLR), expressed in photoreceptors with a high metabolic rate, facilitates the uptake of triglyceri
Externí odkaz:
https://doaj.org/article/2daa7b5d47564630a41d65386cd0a30f
Autor:
Matthew Zirui Tay, Angeline Rouers, Siew‐Wai Fong, Yun Shan Goh, Yi‐Hao Chan, Zi Wei Chang, Weili Xu, Chee Wah Tan, Wan Ni Chia, Anthony Torres‐Ruesta, Siti Naqiah Amrun, Yuling Huang, Pei Xiang Hor, Chiew Yee Loh, Nicholas Kim‐Wah Yeo, Bei Wang, Eve Zi Xian Ngoh, Siti Nazihah Mohd Salleh, Jean‐Marc Chavatte, Alicia Jieling Lim, Sebastian Maurer‐Stroh, Lin‐Fa Wang, Raymond Valentine Tzer Pin Lin, Cheng‐I Wang, Seow‐Yen Tan, Barnaby Edward Young, Yee‐Sin Leo, David C Lye, Laurent Renia, Lisa FP Ng
Publikováno v:
EMBO Molecular Medicine, Vol 14, Iss 3, Pp n/a-n/a (2022)
Abstract The SARS‐CoV‐2 Delta (B.1.617.2) variant is capable of infecting vaccinated persons. An open question remains as to whether deficiencies in specific vaccine‐elicited immune responses result in susceptibility to vaccine breakthrough inf
Externí odkaz:
https://doaj.org/article/34cfbff82720458e9823ad77b78c0e87
Autor:
Guillaume Carissimo, Weili Xu, Immanuel Kwok, Mohammad Yazid Abdad, Yi-Hao Chan, Siew-Wai Fong, Kia Joo Puan, Cheryl Yi-Pin Lee, Nicholas Kim-Wah Yeo, Siti Naqiah Amrun, Rhonda Sin-Ling Chee, Wilson How, Stephrene Chan, Bingwen Eugene Fan, Anand Kumar Andiappan, Bernett Lee, Olaf Rötzschke, Barnaby Edward Young, Yee-Sin Leo, David Chien Lye, Laurent Renia, Lai Guan Ng, Anis Larbi, Lisa FP Ng
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
COVID-19 severity is associated with cytokine levels and lymphopenia, but the role of immune cell subsets is not well understood. Here the authors immunophenotype whole blood samples from 54 COVID-19 patients and find that the immature neutrophil-to-
Externí odkaz:
https://doaj.org/article/d967340f6639442885027de8b53a2e43
Autor:
Chek Meng Poh, Guillaume Carissimo, Bei Wang, Siti Naqiah Amrun, Cheryl Yi-Pin Lee, Rhonda Sin-Ling Chee, Siew-Wai Fong, Nicholas Kim-Wah Yeo, Wen-Hsin Lee, Anthony Torres-Ruesta, Yee-Sin Leo, Mark I-Cheng Chen, Seow-Yen Tan, Louis Yi Ann Chai, Shirin Kalimuddin, Shirley Seah Gek Kheng, Siew-Yee Thien, Barnaby Edward Young, David C. Lye, Brendon John Hanson, Cheng-I Wang, Laurent Renia, Lisa F. P. Ng
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-7 (2020)
Characterisation of the human antibody response to SARS-CoV-2 can help the design of serological tests and vaccines. Here, the authors identify two linear epitopes in SARS-CoV-2 spike protein that elicit neutralising antibodies in several patients an
Externí odkaz:
https://doaj.org/article/259727a9ff5945239e9dc10420f01ef8
Autor:
Jenna Cusic, MD, Anna Garbuzov, BA, Kristopher Katira, MD, Nicholas Kim, MD, John LoGiudice, MD, John Hijjawi, MD, Erin Doren, MD, MBA
Publikováno v:
Plastic and Reconstructive Surgery, Global Open, Vol 10, Iss 1, p e4021 (2022)
Externí odkaz:
https://doaj.org/article/0d5122a85edc45bc8e06dd97f52f1510
Autor:
Jackwee Lim, Kia Joo Puan, Liang Wei Wang, Karen Wei Weng Teng, Chiew Yee Loh, Kim Peng Tan, Guillaume Carissimo, Yi-Hao Chan, Chek Meng Poh, Cheryl Yi-Pin Lee, Siew-Wai Fong, Nicholas Kim-Wah Yeo, Rhonda Sin-Ling Chee, Siti Naqiah Amrun, Zi Wei Chang, Matthew Zirui Tay, Anthony Torres-Ruesta, Norman Leo Fernandez, Wilson How, Anand Kumar Andiappan, Wendy Lee, Kaibo Duan, Seow-Yen Tan, Gabriel Yan, Shirin Kalimuddin, David Chien Lye, Yee-Sin Leo, Sean W. X. Ong, Barnaby E. Young, Laurent Renia, Lisa F. P. Ng, Bernett Lee, Olaf Rötzschke
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Severe SARS-CoV-2 infection can trigger uncontrolled innate and adaptive immune responses, which are commonly associated with lymphopenia and increased neutrophil counts. However, whether the immune abnormalities observed in mild to severely infected
Externí odkaz:
https://doaj.org/article/09415a4209cb486cbf1d519aa8d7c6ff