Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Nicholas K Conrad"'
Autor:
Anna M Scarborough, Juliana N Flaherty, Olga V Hunter, Kuanqing Liu, Ashwani Kumar, Chao Xing, Benjamin P Tu, Nicholas K Conrad
Publikováno v:
eLife, Vol 10 (2021)
S-adenosylmethionine (SAM) is the methyl donor for nearly all cellular methylation events. Cells regulate intracellular SAM levels through intron detention of MAT2A, the only SAM synthetase expressed in most cells. The N6-adenosine methyltransferase
Externí odkaz:
https://doaj.org/article/ac2b0adbe78347f28a8d8a053ebe0d0d
Publikováno v:
PLoS Pathogens, Vol 15, Iss 2, p e1007596 (2019)
Nuclear RNAs are subject to a number of RNA decay pathways that serve quality control and regulatory functions. As a result, any virus that expresses its genes in the nucleus must have evolved mechanisms that avoid these pathways, but the how viruses
Externí odkaz:
https://doaj.org/article/5da153a3148942019e30282de03636b2
Autor:
Sandip Chorghade, Joseph Seimetz, Russell Emmons, Jing Yang, Stefan M Bresson, Michael De Lisio, Gianni Parise, Nicholas K Conrad, Auinash Kalsotra
Publikováno v:
eLife, Vol 6 (2017)
The rate of protein synthesis in the adult heart is one of the lowest in mammalian tissues, but it increases substantially in response to stress and hypertrophic stimuli through largely obscure mechanisms. Here, we demonstrate that regulated expressi
Externí odkaz:
https://doaj.org/article/52bf020580d04a7c968b04881eccf087
Publikováno v:
PLoS Genetics, Vol 11, Iss 10, p e1005610 (2015)
The human nuclear poly(A)-binding protein PABPN1 has been implicated in the decay of nuclear noncoding RNAs (ncRNAs). In addition, PABPN1 promotes hyperadenylation by stimulating poly(A)-polymerases (PAPα/γ), but this activity has not previously be
Externí odkaz:
https://doaj.org/article/1091ce2dd313443782a8984af4ab9cc3
Publikováno v:
PLoS Pathogens, Vol 11, Iss 2, p e1004652 (2015)
The Kaposi's sarcoma associated herpesvirus (KSHV) is an oncogenic virus that causes Kaposi's sarcoma, primary effusion lymphoma (PEL), and some forms of multicentric Castleman's disease. The KSHV ORF57 protein is a conserved posttranscriptional regu
Externí odkaz:
https://doaj.org/article/0a1b62ba3e46404f9d1f86dfb47837f7
Autor:
Stefan M Bresson, Nicholas K Conrad
Publikováno v:
PLoS Genetics, Vol 9, Iss 10, p e1003893 (2013)
Control of nuclear RNA stability is essential for proper gene expression, but the mechanisms governing RNA degradation in mammalian nuclei are poorly defined. In this study, we uncover a mammalian RNA decay pathway that depends on the nuclear poly(A)
Externí odkaz:
https://doaj.org/article/3505df8e58aa48328fcc8e94c2215ad0
Publikováno v:
PLoS Pathogens, Vol 6, Iss 3, p e1000799 (2010)
The control of RNA stability is a key determinant in cellular gene expression. The stability of any transcript is modulated through the activity of cis- or trans-acting regulatory factors as well as cellular quality control systems that ensure the in
Externí odkaz:
https://doaj.org/article/1e18915f7c0c43a784cf052e046cc640
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2537
Intron retention (IR) regulates gene expression to control fundamental biological processes like metabolism, differentiation, and cell cycle. Despite a wide variety of genes controlled by IR, few techniques are available to identify regulators of IR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7efe2c4ac895ad6c989e2715d20cec4b
https://pubmed.ncbi.nlm.nih.gov/35895270
https://pubmed.ncbi.nlm.nih.gov/35895270
Autor:
Sarah E. Dremel, Vishal N. Kopardé, Jesse H. Arbuckle, Thomas M. Kristie, Laurie T. Krug, Nicholas K. Conrad, Joseph M. Ziegelbauer
SUMMARYHerpesviruses express over 100 transcripts, including messenger RNAs, long noncoding RNAs, and microRNAs. Herein, we add to this list by performing circular RNA (circRNA) profiling for Herpes Simplex Virus-1, Kaposi sarcoma-associated herpesvi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8d149aabed7353f99c2e2b75aa3bfaaa
https://doi.org/10.1101/2022.07.08.499347
https://doi.org/10.1101/2022.07.08.499347
Autor:
Anne M, Devlin, Ashutosh, Shukla, Julio C, Ruiz, Spencer D, Barnes, Ashwin, Govindan, Olga V, Hunter, Anna M, Scarborough, Iván, D'Orso, Nicholas K, Conrad
Publikováno v:
Nature communications. 13(1)
Control of RNA Polymerase II (pol II) elongation is a critical component of gene expression in mammalian cells. The PNUTS-PP1 complex controls elongation rates, slowing pol II after polyadenylation sites to promote termination. The Kaposi's sarcoma-a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::93a64cf38244347392d4f8470276084d
https://pubmed.ncbi.nlm.nih.gov/36460671
https://pubmed.ncbi.nlm.nih.gov/36460671