Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Nicholas K, Conrad"'
Autor:
Anne M. Devlin, Ashutosh Shukla, Julio C. Ruiz, Spencer D. Barnes, Ashwin Govindan, Olga V. Hunter, Anna M. Scarborough, Iván D’Orso, Nicholas K. Conrad
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
The PNUTS-PP1 complex directly binds to RNA, and interacts with polymerase II and RNA processing factors to control transcriptional elongation rates and slow polymerase II after polyadenylation sites to promote termination. Using a genome-wide CRISPR
Externí odkaz:
https://doaj.org/article/c1f1e4399fcb427bafd71414e6943423
Autor:
Anna M Scarborough, Juliana N Flaherty, Olga V Hunter, Kuanqing Liu, Ashwani Kumar, Chao Xing, Benjamin P Tu, Nicholas K Conrad
Publikováno v:
eLife, Vol 10 (2021)
S-adenosylmethionine (SAM) is the methyl donor for nearly all cellular methylation events. Cells regulate intracellular SAM levels through intron detention of MAT2A, the only SAM synthetase expressed in most cells. The N6-adenosine methyltransferase
Externí odkaz:
https://doaj.org/article/ac2b0adbe78347f28a8d8a053ebe0d0d
Autor:
Sung-Kyun Park, Xiaorong Zhou, Kathryn E. Pendleton, Olga V. Hunter, Jennifer J. Kohler, Kathryn A. O’Donnell, Nicholas K. Conrad
Publikováno v:
Cell Reports, Vol 20, Iss 5, Pp 1088-1099 (2017)
Summary: Modification of nucleocytoplasmic proteins with O-GlcNAc regulates a wide variety of cellular processes and has been linked to human diseases. The enzymes O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA) add and remove O-GlcNAc, but the mech
Externí odkaz:
https://doaj.org/article/0556ea66b2484836afad5c9c7b1f3fcc
Publikováno v:
PLoS Pathogens, Vol 15, Iss 2, p e1007596 (2019)
Nuclear RNAs are subject to a number of RNA decay pathways that serve quality control and regulatory functions. As a result, any virus that expresses its genes in the nucleus must have evolved mechanisms that avoid these pathways, but the how viruses
Externí odkaz:
https://doaj.org/article/5da153a3148942019e30282de03636b2
Autor:
Sandip Chorghade, Joseph Seimetz, Russell Emmons, Jing Yang, Stefan M Bresson, Michael De Lisio, Gianni Parise, Nicholas K Conrad, Auinash Kalsotra
Publikováno v:
eLife, Vol 6 (2017)
The rate of protein synthesis in the adult heart is one of the lowest in mammalian tissues, but it increases substantially in response to stress and hypertrophic stimuli through largely obscure mechanisms. Here, we demonstrate that regulated expressi
Externí odkaz:
https://doaj.org/article/52bf020580d04a7c968b04881eccf087
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2537
Intron retention (IR) regulates gene expression to control fundamental biological processes like metabolism, differentiation, and cell cycle. Despite a wide variety of genes controlled by IR, few techniques are available to identify regulators of IR
Autor:
Sarah E. Dremel, Vishal N. Kopardé, Jesse H. Arbuckle, Thomas M. Kristie, Laurie T. Krug, Nicholas K. Conrad, Joseph M. Ziegelbauer
SUMMARYHerpesviruses express over 100 transcripts, including messenger RNAs, long noncoding RNAs, and microRNAs. Herein, we add to this list by performing circular RNA (circRNA) profiling for Herpes Simplex Virus-1, Kaposi sarcoma-associated herpesvi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8d149aabed7353f99c2e2b75aa3bfaaa
https://doi.org/10.1101/2022.07.08.499347
https://doi.org/10.1101/2022.07.08.499347
Publikováno v:
Methods in Molecular Biology ISBN: 9781071625200
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::32b64198fd84b5d56d9fe648d86b0f5c
https://doi.org/10.1007/978-1-0716-2521-7_16
https://doi.org/10.1007/978-1-0716-2521-7_16
Publikováno v:
PLoS Genetics, Vol 11, Iss 10, p e1005610 (2015)
The human nuclear poly(A)-binding protein PABPN1 has been implicated in the decay of nuclear noncoding RNAs (ncRNAs). In addition, PABPN1 promotes hyperadenylation by stimulating poly(A)-polymerases (PAPα/γ), but this activity has not previously be
Externí odkaz:
https://doaj.org/article/1091ce2dd313443782a8984af4ab9cc3
Publikováno v:
PLoS Pathogens, Vol 11, Iss 2, p e1004652 (2015)
The Kaposi's sarcoma associated herpesvirus (KSHV) is an oncogenic virus that causes Kaposi's sarcoma, primary effusion lymphoma (PEL), and some forms of multicentric Castleman's disease. The KSHV ORF57 protein is a conserved posttranscriptional regu
Externí odkaz:
https://doaj.org/article/0a1b62ba3e46404f9d1f86dfb47837f7