Zobrazeno 1 - 10 of 68 pro vyhledávání: '"Nicholas John Bray"'
1
Schizophrenia Genomics: Convergence on Synaptic Development, Adult Synaptic Plasticity, or Both?
Autor: Nicholas John Bray, Jeremy Hall
Publikováno v: Biological Psychiatry. 91:709-717
Large-scale genomic studies of schizophrenia have identified hundreds of genetic loci conferring risk to the disorder. This progress offers an important route toward defining the biological basis of the condition and potentially developing new treatm
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::382976201cab406ea97e776ae1483258
https://doi.org/10.1016/j.biopsych.2021.10.018
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2
Cis-effects on gene expression in the human prenatal brain associated with genetic risk for neuropsychiatric disorders
Autor: Michael Conlon O'Donovan, Michael John Owen, James T.R. Walters, Nicholas John Bray, Oliver Pain, Heath E. O’Brien, Lynsey S. Hall, Richard Anney
Publikováno v: Molecular psychiatry
The majority of common risk alleles identified for neuropsychiatric disorders reside in noncoding regions of the genome and are therefore likely to impact gene regulation. However, the genes that are primarily affected and the nature and developmenta
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::baac4a76bde90af9e54b75ce1851ce9a
http://europepmc.org/articles/PMC7611670
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3
CSF-resident CD4+ T-cells display a distinct gene expression profile with relevance to immune surveillance and multiple sclerosis
Autor: Nigel Williams, James Hrastelj, Neil Robertson, Joanne E. Morgan, Nicholas John Bray, Robert Andrews, Stefan Mark Bishop, Samantha Loveless
Publikováno v: Brain Communications
The CNS has traditionally been considered an immune privileged site, but is now understood to have a system of immune surveillance, predominantly involving CD4+ T-cells. Identifying functional differences between CNS and blood CD4+ T-cells, therefore
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4d03bf28d28cf8376273c1b046e6f99
https://doi.org/10.1093/braincomms/fcab155
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5
A transcriptome-wide association study implicates specific pre- and post-synaptic abnormalities in schizophrenia
Autor: Oliver Pain, James T.R. Walters, Michael Conlon O'Donovan, Christopher W Medway, Lynsey S. Hall, Nicholas John Bray, Elliott Rees, Peter Holmans, Andrew Pocklington, Valentina Escott-Price, Antonio F. Pardiñas, Michael J. Owen
Publikováno v: Human Molecular Genetics
Schizophrenia is a complex highly heritable disorder. Genome-wide association studies (GWAS) have identified multiple loci that influence the risk of developing schizophrenia, although the causal variants driving these associations and their impacts
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36e568584083dd90cf262b3d75a698fa
https://doi.org/10.1093/hmg/ddz253
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6
No Effect of Genome-Wide Significant Schizophrenia Risk Variation at the DRD2 Locus on the Allelic Expression of DRD2 in Postmortem Striatum
Autor: Nicholas John Bray, Sashika Selvackadunco, Claire Troakes, Rodrigo R.R. Duarte, Matthew Hill, Carolina Toste, Aaron R. Jeffries, Michael Conlon O'Donovan
Publikováno v: Complex Psychiatry. 5:212-217
A genome-wide significant association has been reported between non-coding variants at the dopamine D2 receptor (DRD2) gene locus and schizophrenia. However, effects of identified schizophrenia risk alleles on DRD2 function are yet to be demonstrated
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::82face5a50d6d035ac0ce6a657fe9b01
https://doi.org/10.1159/000501022
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7
Transcriptional Changes following Cellular Knockdown of the Schizophrenia Risk Gene SETD1A Are Enriched for Common Variant Association with the Disorder
Autor: D. F. Cameron, Derek J. Blake, Nicholas John Bray, Matthew Hill
Publikováno v: Complex Psychiatry. 5:109-114
Loss of function mutations in SETD1A are the first experiment-wide significant findings to emerge from exome sequencing studies of schizophrenia. Although SETD1Ais known to encode a histone methyltransferase, the consequences of reduced SETD1A activi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::25cfc09852d9456d4e8a6e00f0303e1b
https://doi.org/10.1159/000497181
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8
Sites of active gene regulation in the prenatal frontal cortex and their role in neuropsychiatric disorders
Autor: Manuela R. Kouakou, Matthew Hill, Nicholas John Bray, Jonathan Mill, Eilis Hannon, Emma Dempster, D. F. Cameron
Publikováno v: American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric GeneticsREFERENCES. 186(6)
Common genetic variation appears to largely influence risk for neuropsychiatric disorders through effects on gene regulation. It is therefore possible to shed light on the biology of these conditions by testing for enrichment of associated genetic va
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a710eb019cd19e0d9ee6d1ebfe89061
https://pubmed.ncbi.nlm.nih.gov/34632689
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