Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Nicholas J.E. Starkey"'
Publikováno v:
Endocrinology. 159:1972-1981
Estrogens bind to two nuclear estrogen receptor (ER) subtypes, ERα and ERβ, which are expressed in differing amounts in various tissues. The endogenous estrogen, 17β-estradiol (E2), binds to both subtypes with nearly equal affinity and is the prot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c240dcbec0b294e69a43962fdd6d426c
https://doi.org/10.1210/en.2018-00081
https://doi.org/10.1210/en.2018-00081
Autor:
Kevin L. Fritsche, Cynthia Besch-Williford, George E. Rottinghaus, Y. C. Li, Nicholas J.E. Starkey, Monica Peña-Luna, Dennis B. Lubahn, Nathaniel W. Mahloch
3,3′-Diindolylmethane (DIM) is an acid-derived dimer of indole-3-carbinol, found in many cruciferous vegetables, such as broccoli, and has been shown to inhibit prostate cancer (PCa) in several in vitro and in vivo models. We demonstrated that DIM
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b680018752928de05bebd40e1792e85c
Autor:
Glenn A. Jackson, Hui Lin, Korey J. Brownstein, Sara K. Drenkhahn, Nicholas J.E. Starkey, Yong Zhang, Kevin L. Fritsche, William R. Lamberson, Yuan Lu, Valeri V. Mossine, William R. Folk, Cynthia Besch-Williford, Dennis B. Lubahn
Publikováno v:
Cell Biology International. 40:131-142
Sutherlandia frutescens is a medicinal plant, traditionally used to treat various types of human diseases, including cancer. Previous studies of several botanicals link suppression of prostate cancer growth with inhibition of the Gli/hedgehog (Gli/Hh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e31839a61cdc831853ae8ec621bccf5e
https://doi.org/10.1002/cbin.10544
https://doi.org/10.1002/cbin.10544
Autor:
Jilong Li, Nicholas J.E. Starkey, Wei Lei, William R. Folk, Yuan Lu, Dennis B. Lubahn, Jianlin Cheng
Publikováno v:
PLoS ONE
PLoS ONE, Vol 10, Iss 12, p e0145507 (2015)
PLoS ONE, Vol 10, Iss 12, p e0145507 (2015)
Sutherlandia frutescens (L) R. Br. (Sutherlandia) is a South African botanical that is traditionally used to treat a variety of health conditions, infections and diseases, including cancer. We hypothesized Sutherlandia might act through Gli/ Hedgehog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc652ed7bfc4bfc9153ea89c4b2a64e0
http://europepmc.org/articles/PMC4694108
http://europepmc.org/articles/PMC4694108
Publikováno v:
Current cancer drug targets. 13(5)
The hedgehog (Hh) signaling pathway is an important therapeutic target in cancer; involvement of the Hh pathway has been shown in a variety of cancers including basal cell carcinoma, medulloblastoma, leukemia, and gastrointestinal, breast, prostate,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::363216186c7deaebfb759805d81a96c8
https://pubmed.ncbi.nlm.nih.gov/23675897
https://pubmed.ncbi.nlm.nih.gov/23675897
Publikováno v:
Cancer Research. 74:2104-2104
We have previously shown that Estrogen Related Receptor Beta - Short Form (ERRβ-SF) inhibits the transcriptional activity of the Estrogen Receptors Alpha (ERα) and Beta (ERβ). Our lab and others have also shown the importance of these receptors in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0dcf41ee00921d33b198e9d4d0abb365
https://doi.org/10.1158/1538-7445.am2014-2104
https://doi.org/10.1158/1538-7445.am2014-2104
Autor:
Charles E. Wiedmeyer, Nicholas J.E. Starkey, Kevin L. Fritsche, Dennis B. Lubahn, Glenn A. Jackson, Jimmy D. Browning, Y. C. Li, Cynthia Besch-Williford, Roxanne E. Gelven, Sara K. Drenkhahn
Publikováno v:
Cancer Research. 73:1520-1520
Due to mounting epidemiological data evidence, we sought to determine if simvastatin, the most widely used cholesterol lowering medication, could alter prostate cancer incidence in the TRAMP mouse model of prostate cancer. We hypothesized that simvas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::66ffb4dc5e65f9d1a9dd80863aa21027
https://doi.org/10.1158/1538-7445.am2013-1520
https://doi.org/10.1158/1538-7445.am2013-1520
Autor:
George E. Rottinghaus, Glenn A. Jackson, Nicholas J.E. Starkey, William R. Folk, Sara K. Drenkhahn, Yuan Lu, Cindy Besch-Williford, Jimmy D. Browning, Wei Lei, Christal D. Huber, Dennis B. Lubahn, Kevin L. Fritsche, Hui Lin
Publikováno v:
Cancer Research. 72:1998-1998
Prostate cancer possesses long latency periods and is responsive to dietary mediators, making it a target for phytochemoprevention. Many botanical compounds that have been proposed to prevent cancer may potentially work via inhibition of the hedgehog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::247b274313b91f4ee417f0841a66ecdb
https://doi.org/10.1158/1538-7445.am2012-1998
https://doi.org/10.1158/1538-7445.am2012-1998
Autor:
William R. Folk, Nicholas J.E. Starkey, Sara K. Drenkhahn, Yuan Lu, Hui Lin, Dennis B. Lubahn, Kevin L. Fritsche, Glenn A. Jackson
Publikováno v:
Cancer Research. 71:4221-4221
Many botanical compounds that have been proposed to prevent cancer may potentially work via inhibition of the hedgehog-signaling pathway. Here we investigated the potential of Sutherlandia frutescens (also called “cancer bush” in South Africa) to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e84f18d21f8254acbde9469842afc69c
https://doi.org/10.1158/1538-7445.am2011-4221
https://doi.org/10.1158/1538-7445.am2011-4221
Autor:
Glenn A. Jackson, Hui Lin, Sara K. Drenkhahn, Nicholas J.E. Starkey, William R. Folk, Andrew L. Thomas, Yuan Lu, Kevin L. Fritsche, Dennis B. Lubahn
Publikováno v:
Cancer Research. 70:5705-5705
Many botanical compounds, which have been proposed to prevent cancer, may potentially work via inhibition of the hedgehog-signaling pathway. Here we investigated the potential of Sutherlandia and elderberry to prevent and/or treat prostate cancer by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ff68ad6ebb9dafb1585bfe8683643265
https://doi.org/10.1158/1538-7445.am10-5705
https://doi.org/10.1158/1538-7445.am10-5705