Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Nicholas J. Wells"'
Autor:
Ian D. Hickson, Nicholas J. Wells
Publikováno v:
European Journal of Biochemistry. 231:491-497
Topoisomerase II is essential for chromosome condensation and segregation at mitosis in eukaryotic cells, but the mechanism of its regulation is not clearly understood. We have investigated whether or not the a isozyme of human topoisomerase II is ph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bb5cf9f28eb4f0cb2431611604b89f4b
https://doi.org/10.1111/j.1432-1033.1995.0491e.x
https://doi.org/10.1111/j.1432-1033.1995.0491e.x
Publikováno v:
Current Biology. 11(10):784-788
The Dbf2 protein kinase functions as part of the mitotic-exit network (MEN), which controls the inactivation of the Cdc28-Clb2 kinase in late mitosis [1]. The MEN includes the Tem1 GTP binding protein; the kinases Cdc15 and Cdc5; Mob1, a protein of u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df598a11b4e95ee9bef9619b0245c3bc
Publikováno v:
Proceedings of the National Academy of Sciences. 96:6193-6198
We have characterized HsCdc6, a human protein homologous to the budding yeast Cdc6p that is essential for DNA replication. We show that, unlike Cdc6p, the levels of HsCdc6 protein remain constant throughout the cell cycle in human cells. However, pho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::689f96dd90febd110c04de8a829a9de2
https://doi.org/10.1073/pnas.96.11.6193
https://doi.org/10.1073/pnas.96.11.6193
Autor:
Nicholas J. Wells, Rikiro Fukunaga, Geoffrey M. Wahl, Tony Hunter, Gretchen S. Jimenez, Wei Jiang, Thomas J. Hope
Publikováno v:
Molecular Cell. 2:877-885
We have identified a novel human protein, PRC1, that is involved in cytokinesis. PRC1 is a good substrate for several CDKs in vitro and is phosphorylated in vivo at sites that are phosphorylated by CDK in vitro, strongly suggesting that PRC1 is an in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b4bca24c98b7356e1e42fe0fcbbd89c
https://doi.org/10.1016/s1097-2765(00)80302-0
https://doi.org/10.1016/s1097-2765(00)80302-0
Autor:
Richard J. Isaacs, Charles Redwood, Nicholas J. Wells, M. Ines Sandri, Ian D. Hickson, Sally L. Davies
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1400:121-137
Topoisomerase II is an essential enzyme in all organisms with several independent roles in DNA metabolism. In this article we review our knowledge on the regulation of the expression and catalytic activity of topoisomerase II in both lower and higher
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a27ad2f50d6b41f6b3089da5cd155c62
https://doi.org/10.1016/s0167-4781(98)00131-6
https://doi.org/10.1016/s0167-4781(98)00131-6
Publikováno v:
Journal of Biological Chemistry. 270:28357-28363
Type II topoisomerases are essential for faithful cell division in all organisms. In human cells, the α isozyme of topoisomerase II has been implicated in catalyzing mitotic chromosome segregation via its action as a DNA unlinking enzyme. Here, we h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a1355ed2f4dcb6cc109bf684f94aca3d
https://doi.org/10.1074/jbc.270.47.28357
https://doi.org/10.1074/jbc.270.47.28357
Publikováno v:
Anti-Cancer Drugs. 6:195-212
Topoisomerase II enzymes play an essential role in human DNA metabolism. They are also recognized as primary targets of a number of anti-cancer drugs used in the treatment of breast cancer, which remains a leading cause of cancer-related death in wom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::99f7594d18ce44788ff6cf3f73da2917
https://doi.org/10.1097/00001813-199504000-00002
https://doi.org/10.1097/00001813-199504000-00002
Publikováno v:
Journal of Biological Chemistry. 269:29746-29751
Topoisomerase II protein is essential for cell proliferation and is known to exist as a phosphoprotein in cells from both lower and higher eukaryotic species. In this paper, we have investigated the phosphorylation of the alpha isozyme of human topoi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b13bb0e599952b48984000027e2f79c9
https://doi.org/10.1016/s0021-9258(18)43944-0
https://doi.org/10.1016/s0021-9258(18)43944-0
Autor:
Joseph P. Noel, Claudio A. P. Joazeiro, Marianne E. Bowman, Nicholas J. Wells, Tony Hunter, Jean-Luc Ferrer, Mark A. Verdecia
Publikováno v:
Molecular cell. 11(1)
Ubiquitin ligases (E3) select proteins for ubiquitylation, a modification that directs altered subcellular trafficking and/or degradation of the target protein. HECT domain E3 ligases not only recognize, but also directly catalyze, ligation of ubiqui
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23ab9e6d88423b27fd9dbfe571d52a37
https://pubmed.ncbi.nlm.nih.gov/12535537
https://pubmed.ncbi.nlm.nih.gov/12535537