Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Nicholas J. Sullivan"'
Autor:
En-Chi Hsu, Samuel K. Kulp, Han-Li Huang, Huang-Ju Tu, Santosh B. Salunke, Nicholas J. Sullivan, Duxin Sun, Max S. Wicha, Charles L. Shapiro, Ching-Shih Chen
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 17, Iss 6, Pp 497-508 (2015)
Interleukin-6 (IL-6) and Notch signaling are important regulators of breast cancer stem cells (CSCs), which drive the malignant phenotype through self-renewal, differentiation, and development of therapeutic resistance. We investigated the role of in
Externí odkaz:
https://doaj.org/article/12a299e1a5344f7dbab1382a814fe3d7
Autor:
Theo Rulko, Mirella Deng, Tanya Nguyen, Hana Samad, Ewan Wa, Susan M. Wall, Kayra Erisoglu‐Akyildiz, Rebecca Muscant, Mason Xiao, Zachary Chafe, Flavia Dumitrascu, Nicholas J. Sullivan, Alexandra Akman, Isabela Hernandez-Oviedo, Catherina Niu, Yuxin Wu, Kevin Hu, Alyssa Chow
Publikováno v:
The FASEB Journal. 32
Publikováno v:
Research in Social and Administrative Pharmacy. 15:e10
Integrin-linked kinase as a novel molecular switch of the IL-6-NF-κB signaling loop in breast cancer
Autor:
Jianying Zhang, Ming Chen Yang, Che-Ming Teng, Samuel K. Kulp, Max S. Wicha, Wen Chung Chen, Ching-Shih Chen, Huang Ju Tu, Santosh B. Salunke, Han Li Huang, En-Chi Hsu, Yu Chou Tseng, Duxin Sun, Nicholas J. Sullivan, Charles L. Shapiro, Min Wu Chao, Wen-Mei Fu
Publikováno v:
Carcinogenesis. 37(4)
Substantial evidence has clearly demonstrated the role of the IL-6-NF-κB signaling loop in promoting aggressive phenotypes in breast cancer. However, the exact mechanism by which this inflammatory loop is regulated remains to be defined. Here, we re
Autor:
A. Kate Sasser, Amy Axel, Nicholas J. Sullivan, Adam W. Studebaker, Lindsay F. Hendey, Brett Hall
Publikováno v:
The FASEB Journal. 21:3763-3770
Bone is the primary anatomical site of breast cancer metastasis, and bone metastasis is associated with increased morbidity and mortality. Mesenchymal stem cells (MSC) are a predominant fibroblast cell population within the bone marrow, and metastati
Autor:
Bhuvaneswari Ramaswamy, Michael C. Ostrowski, Morag Park, Nicholas J. Sullivan, Kyle Toth, Vincenzo Coppola, Piotr Daniel, Ali Tofigh, Gustavo Leone, Connor Sullivan, Serena W. Chang, Markus Mair, Jeffrey D. Parvin, Xing Tang, Erin R. Macrae, Yuanzhi Lu, James A. Dowdle, Sarmila Majumder, Lisa D. Yee, Joseph S. Conway, Michael Hallett, Nicholas Bertos, Joseph McElroy, Raleigh D. Kladney, Charles L. Shapiro, Sooin Bae, Siddhant Srivastava, Helen M. Chamberlin, Safiya Khurshid, Matthew J. Sullivan, Michael Lause, Soledad A. Fernandez, Huayang Liu, Karl Eiring, Sadiq M. Saleh, Esther Wheeler, Komal Rambani, Markus E. Harrigan
Publikováno v:
Developmental Cell. 41:392-407.e6
Mesodermal cells signal to neighboring epithelial cells to modulate their proliferation in both normal and disease states. We adapted a Caenorhabditis elegans organogenesis model to enable a genome-wide mesodermal-specific RNAi screen and discovered
Autor:
Nicholas J. Sullivan
Publikováno v:
Breast Cancer-Focusing Tumor Microenvironment, Stem cells and Metastasis
Greater than 200,000 new cases of breast cancer cases were diagnosed in 2010 in the United States, with approximately 40,000 women succumbing to the disease (www.cancer.gov). Globally, an estimated 1.38 million new cases of breast cancer were diagnos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6649010d1969da68d3838270317bbe6
http://www.intechopen.com/articles/show/title/interleukin-6-in-the-breast-tumor-microenvironment
http://www.intechopen.com/articles/show/title/interleukin-6-in-the-breast-tumor-microenvironment
Autor:
Kathleen L. Tober, Gregory B. Lesinski, Matthew A. Bill, Tatiana M. Oberyszyn, Nicholas J. Sullivan, Judith A. Riggenbach, Erin M. Burns, Gregory S. Young, Thomas A. Mace, Jonathan Schick
Publikováno v:
The Journal of investigative dermatology
Skin cancer incidence and mortality are higher in men compared with women, but the causes of this sex discrepancy remain largely unknown. UV light exposure induces cutaneous inflammation and neutralizes cutaneous antioxidants. Gr-1 + CD11b + myeloid
Autor:
Bethany L. Mundy, Brett Hall, Jason Canner, Nicholas J. Sullivan, Amy Axel, Mark Ranalli, Wendy B. London, Patrick McGrady, Joanne Lagmay, Thomas G. Gross, Amanda Termuhlen
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 15(16)
Purpose: Neuroblastoma is a childhood cancer of the sympathetic nervous system and many patients present with high-risk disease. Risk stratification, based on pathology and tumor-derived biomarkers, has improved prediction of clinical outcomes, but o
Autor:
N Ramirez, Farhad Vesuna, Brett Hall, Tatiana M. Oberyszyn, Amy Axel, Venu Raman, Nicholas J. Sullivan, A K Sasser
Publikováno v:
Oncogene
Breast tumor interleukin-6 (IL-6) levels increase with tumor grade, and elevated serum IL-6 correlates with poor breast cancer patient survival. Epithelial-mesenchymal transition (EMT) phenotypes such as impaired E-cadherin expression or aberrant Vim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0137f8ff9028cabb7e0d5be52acf711
https://europepmc.org/articles/PMC5576031/
https://europepmc.org/articles/PMC5576031/