Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Nicholas J. Sinclair"'
Autor:
Sarah A. Michaud, Helena Pětrošová, Nicholas J. Sinclair, Andrea L. Kinnear, Angela M. Jackson, Jamie C. McGuire, Darryl B. Hardie, Pallab Bhowmick, Milan Ganguly, Ann M. Flenniken, Lauryl M. J. Nutter, Colin McKerlie, Derek Smith, Yassene Mohammed, David Schibli, Albert Sickmann, Christoph H. Borchers
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-12 (2024)
Abstract Mouse is the mammalian model of choice to study human health and disease due to its size, ease of breeding and the natural occurrence of conditions mimicking human pathology. Here we design and validate multiple reaction monitoring mass spec
Externí odkaz:
https://doaj.org/article/2609ea2007ea4af7ba418d2b5f7ec603
Autor:
Sarah A. Michaud, Angela M. Jackson, Christoph H. Borchers, Derek Smith, Ann M Flenniken, Nicholas J. Sinclair, Colin McKerlie, Lauryl M. J. Nutter, Milan Ganguly, David Schibli, Helena Pětrošová, Jamie C McGuire
Publikováno v:
Journal of Proteome Research. 20:305-316
We investigated the effect of homogenization strategy and protein precipitation on downstream protein quantitation using multiple reaction monitoring mass spectrometry (MRM-MS). Our objective was to develop a workflow capable of processing disparate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10cd9f8bbb4812ed4cdd8215164df6f6
https://doi.org/10.1021/acs.jproteome.0c00399
https://doi.org/10.1021/acs.jproteome.0c00399
Autor:
Nicholas J. Sinclair, Adam J. Pistawka, Jun Liu, Yassene Mohammed, Lei Chen, Monica H. Elliott, Christoph H. Borchers, Rachael Newman, Michael Chen, Darryl B. Hardie, Azad Eshghi
Publikováno v:
Molecular and Cellular Proteomics, 19(3), 540-553. AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
Molecular & Cellular Proteomics : MCP
Molecular & Cellular Proteomics : MCP
Multiple reaction monitoring with isotope dilution assays were developed for quantification of 200 proteins in dried blood spots, with median inter-day CV of 8%. Developed assays were used to measure the concentration ranges of these 200 proteins in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6fe95265969999dd1d97a89f28a21c4
https://www.sciencedirect.com/science/article/pii/S1535947620350404?via=ihub
https://www.sciencedirect.com/science/article/pii/S1535947620350404?via=ihub
Publikováno v:
Journal of the American Chemical Society. 140(10)
Many indicator displacement assays can detect biological analytes in water, but these often have reduced performance in the presence of an unavoidable component: NaCl. We report here a new self-assembled sensor, DimerDye, that uses a novel photochemi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce13c24419567f3e4e8b0e1ecfb69693
https://pubmed.ncbi.nlm.nih.gov/29461821
https://pubmed.ncbi.nlm.nih.gov/29461821
Autor:
Sarah A. Michaud, Nicholas J. Sinclair, Darryl B. Hardie, Christoph H. Borchers, Juncong Yang, Andrew J. Percy, Adam J. Pistawka, André LeBlanc, Derek Smith, Jillaine I. Proudfoot
Publikováno v:
Journal of proteome research. 16(7)
When quantifying endogenous plasma proteins for fundamental and biomedical research - as well as for clinical applications - precise, reproducible, and robust assays are required. Targeted detection of peptides in a bottom-up strategy is the most com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::319716eab0ef7cd1c2145e28cb1761b2
https://pubmed.ncbi.nlm.nih.gov/28516774
https://pubmed.ncbi.nlm.nih.gov/28516774
Autor:
Christoph H. Borchers, Sarah A. Michaud, Andrew J. Percy, Armando Jardim, Darryl B. Hardie, André LeBlanc, Yassene Mohammed, Suping Zhang, Andrea L. Palmer, Juncong Yang, Nicholas J. Sinclair
Publikováno v:
Proteomics, 17(7)
The mouse is the most commonly used laboratory animal, with more than 14 million mice being used for research each year in North America alone. The number and diversity of mouse models is increasing rapidly through genetic engineering strategies, but
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1d082ac877256ef3cd84e918e39b5d0
http://hdl.handle.net/1887/114821
http://hdl.handle.net/1887/114821
Autor:
André LeBlanc, Sarah A. Michaud, Darryl B. Hardie, Armando Jardim, Suping Zhang, Yassene Mohammed, Christoph H. Borchers, Andrea L. Palmer, Nicholas J. Sinclair, Juncong Yang, Andrew J. Percy
Publikováno v:
PROTEOMICS. 17:1770050
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6669b87830e8553addd099b7e83a2787
https://doi.org/10.1002/pmic.201770050
https://doi.org/10.1002/pmic.201770050