Zobrazeno 1 - 10
of 82
pro vyhledávání: '"Nicholas J. Savill"'
Autor:
Olivia J. S. Macleod, Jean-Mathieu Bart, Paula MacGregor, Lori Peacock, Nicholas J. Savill, Svenja Hester, Sophie Ravel, Jack D. Sunter, Camilla Trevor, Steven Rust, Tristan J. Vaughan, Ralph Minter, Shabaz Mohammed, Wendy Gibson, Martin C. Taylor, Matthew K. Higgins, Mark Carrington
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
African trypanosome infections can persist for years, but immune evasion mechanisms are not fully understood. Here, Macleod et al. identify a trypanosome receptor for mammalian factor H, a negative regulator of the alternative complement pathway, tha
Externí odkaz:
https://doaj.org/article/26bfcfd0e9cc483dae71e8f47f88e8ec
Publikováno v:
Malaria Journal, Vol 18, Iss 1, Pp 1-11 (2019)
Abstract Background The ability of malaria (Plasmodium) parasites to adjust investment into sexual transmission stages versus asexually replicating stages is well known, but plasticity in other traits underpinning the replication rate of asexual stag
Externí odkaz:
https://doaj.org/article/32bab0144b5349b992b547ede97b46af
Autor:
Andrew W. Illius, Karianne Lievaart-Peterson, Tom N. McNeilly, Nicholas J. Savill, Stephen Raverty
Publikováno v:
PLoS ONE, Vol 15, Iss 9 (2020)
Maedi-visna (MV) is a complex lentiviral disease syndrome characterised by long immunological and clinical latencies and chronic progressive inflammatory pathology. Incurable at the individual level, it is widespread in most sheep-keeping countries,
Externí odkaz:
https://doaj.org/article/4a9396f981214d3e968120edc81de0b1
Autor:
Joshua Meehan, Suzanne M McDermott, Alasdair Ivens, Zachary Goodall, Zihao Chen, Zihao Yu, Jia Woo, Tyler Rodshagen, Laura McCleskey, Rebecca Sechrist, Kenneth Stuart, Lanying Zeng, Silvi Rouskin, Nicholas J Savill, Achim Schnaufer, Xiuren Zhang, Jorge Cruz-Reyes
Publikováno v:
Meehan, J, McDermott, S M, Ivens, A, Goodall, Z, Chen, Z, Yu, Z, Woo, J, Rodshagen, T, McCleskey, L, Seachrist, R, Stuart, K D, Zeng, L, Rouskin, S, Savill, N J, Schnaufer, A, Zhang, X & Cruz-Reyes, J 2023, ' Trypanosome RNA helicase KREH2 differentially controls noncanonical editing and putative repressive structure via a novel proposed “bifunctional” gRNA in mRNA A6 ', NAR Genomics and Bioinformatics . https://doi.org/10.1093/nar/gkad453
U-insertion/deletion (U-indel) RNA editing in trypanosome mitochondria is directed by guide RNAs (gRNAs). This editing may developmentally control respiration in bloodstream forms (BSF) and insect procyclic forms (PCF). Holo-editosomes include the ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b68bf9857675bb3b3d84828313abec39
https://www.pure.ed.ac.uk/ws/files/353452655/gkad453.pdf
https://www.pure.ed.ac.uk/ws/files/353452655/gkad453.pdf
Publikováno v:
RNA. 28:972-992
Mitochondrial DNA of protists of order Kinetoplastida comprises thousands of interlinked circular molecules arranged in a network. There are two types of molecules called minicircles and maxicircles. Minicircles encode guide RNA (gRNA) genes whose tr
Autor:
Kimberley F Prior, Daan R van der Veen, Aidan J O'Donnell, Katherine Cumnock, David Schneider, Arnab Pain, Amit Subudhi, Abhinay Ramaprasad, Samuel S C Rund, Nicholas J Savill, Sarah E Reece
Publikováno v:
PLoS Pathogens, Vol 14, Iss 2, p e1006900 (2018)
Circadian rhythms enable organisms to synchronise the processes underpinning survival and reproduction to anticipate daily changes in the external environment. Recent work shows that daily (circadian) rhythms also enable parasites to maximise fitness
Externí odkaz:
https://doaj.org/article/bdfcdfcc0fb04b8fb3d1251aa5bdfd5d
Autor:
Manon, Geerts, Zihao, Chen, Nicolas, Bebronne, Nicholas J, Savill, Achim, Schnaufer, Philippe, Büscher, Nick, Van Reet, Frederik, Van den Broeck
Publikováno v:
NAR genomics and bioinformatics. 4(4)
The World Health Organization targeted
Autor:
Lori Peacock, Olivia J. S. Macleod, Jean-Mathieu Bart, Sophie Ravel, Svenja Hester, Martin C. Taylor, Camilla Trevor, Ralph Minter, Jack D. Sunter, Tristan J. Vaughan, Wendy Gibson, Paula MacGregor, Steven Rust, Matthew K. Higgins, Shabaz Mohammed, Mark Carrington, Nicholas J. Savill
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Macleod, O J S, Bart, J M, MacGregor, P, Peacock, L, Savill, N J, Hester, S, Ravel, S, Sunter, J D, Trevor, C, Rust, S, Vaughan, T J, Minter, R, Mohammed, S, Gibson, W, Taylor, M C, Higgins, M K & Carrington, M 2020, ' A receptor for the complement regulator factor H increases transmission of trypanosomes to tsetse flies ', Nature Communications, vol. 11, no. 1, 1326 . https://doi.org/10.1038/s41467-020-15125-y
Nature Communications
Nature Communications, Nature Publishing Group, 2020, 11, art. 1326 [12 p.]. ⟨10.1038/s41467-020-15125-y⟩
Macleod, O J S, Bart, J-M, Macgregor, P, Peacock, L, Hester, S, Ravel, S, Sunter, J D, Trevor, C, Rust, S, Vaughan, T J, Minter, R, Mohammed, S, Gibson, W, Taylor, M C, Higgins, M K & Carrington, M 2020, ' A receptor for the complement regulator factor H increases transmission of trypanosomes to tsetse flies ', Nature Communications, vol. 11, 1326 (2020) . https://doi.org/10.1038/s41467-020-15125-y
Macleod, O J S, Bart, J M, MacGregor, P, Peacock, L, Savill, N J, Hester, S, Ravel, S, Sunter, J D, Trevor, C, Rust, S, Vaughan, T J, Minter, R, Mohammed, S, Gibson, W, Taylor, M C, Higgins, M K & Carrington, M 2020, ' A receptor for the complement regulator factor H increases transmission of trypanosomes to tsetse flies ', Nature Communications, vol. 11, no. 1, 1326 . https://doi.org/10.1038/s41467-020-15125-y
Nature Communications
Nature Communications, Nature Publishing Group, 2020, 11, art. 1326 [12 p.]. ⟨10.1038/s41467-020-15125-y⟩
Macleod, O J S, Bart, J-M, Macgregor, P, Peacock, L, Hester, S, Ravel, S, Sunter, J D, Trevor, C, Rust, S, Vaughan, T J, Minter, R, Mohammed, S, Gibson, W, Taylor, M C, Higgins, M K & Carrington, M 2020, ' A receptor for the complement regulator factor H increases transmission of trypanosomes to tsetse flies ', Nature Communications, vol. 11, 1326 (2020) . https://doi.org/10.1038/s41467-020-15125-y
Persistent pathogens have evolved to avoid elimination by the mammalian immune system including mechanisms to evade complement. Infections with African trypanosomes can persist for years and cause human and animal disease throughout sub-Saharan Afric
Autor:
Manon Geerts, Zihao Chen, Nicolas Bebronne, Nicholas J Savill, Achim Schnaufer, Philippe Büscher, Nick Van Reet, Frederik Van den Broeck
Publikováno v:
Geerts, M, Chen, Z, Bebronne, N, Savill, N J, Schnaufer, A, Büscher, P, Van Reet, N & Van den Broeck, F 2022, ' Deep kinetoplast genome analyses result in a novel molecular assay for detecting trypanosoma brucei gambiense-specific minicircles ', NAR Genomics and Bioinformatics, vol. 4, no. 4, lqac081 . https://doi.org/10.1093/nargab/lqac081
The World Health Organization targeted Trypanosoma brucei gambiense (Tbg) human African trypanosomiasis for elimination of transmission by 2030. Sensitive molecular markers that specifically detect Tbg type 1 (Tbg1) parasites will be important tools
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be6f5b7e155276cfd1324126a351d7fb
https://lirias.kuleuven.be/handle/20.500.12942/695831
https://lirias.kuleuven.be/handle/20.500.12942/695831
Publikováno v:
RNA (New York, N.Y.). 28(7)
Mitochondrial DNA of protists of order