Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Nicholas J. Penington"'
Autor:
Marco A Navarro, Autoosa Salari, Jenna L Lin, Luke M Cowan, Nicholas J Penington, Mirela Milescu, Lorin S Milescu
Publikováno v:
eLife, Vol 9 (2020)
Voltage-gated sodium channels play a critical role in cellular excitability, amplifying small membrane depolarizations into action potentials. Interactions with auxiliary subunits and other factors modify the intrinsic kinetic mechanism to result in
Externí odkaz:
https://doaj.org/article/24456da1dd444b96a12bd4105188c12d
Autor:
Autoosa Salari, Nicholas J. Penington, Marco A. Navarro, Luke M Cowan, Mirela Milescu, Jenna L. Lin, Lorin S. Milescu
Publikováno v:
eLife
eLife, Vol 9 (2020)
eLife, Vol 9 (2020)
Voltage-gated sodium channels play a critical role in cellular excitability, amplifying small membrane depolarizations into action potentials. Interactions with auxiliary subunits and other factors modify the intrinsic kinetic mechanism to result in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::482cd40b0362dd0e3bb5d01fc7f6246e
http://europepmc.org/articles/PMC7043890
http://europepmc.org/articles/PMC7043890
Publikováno v:
Journal of cellular physiologyREFERENCES. 235(10)
TRPC5 channels are nonselective cation channels activated by G-protein-coupled receptors. It was previously found that recombinant TRPC5 currents are inhibited by intracellular ATP, when studied by whole-cell patch-clamp recording. In the present stu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80de6c4b073d76b95756a7c22e956aba
https://pubmed.ncbi.nlm.nih.gov/31994734
https://pubmed.ncbi.nlm.nih.gov/31994734
Publikováno v:
European Journal of Pharmacology. 706:84-91
The 5-Hydroxytriptamine 1A receptor (5-HT1A) is expressed both as a pre- and post-synaptic receptor in neurons. The presynaptic receptor preferentially desensitizes compared to post-synaptic receptors, suggesting different underlying mechanisms of ag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fe145035777ad148dbb06e7e380c7402
https://doi.org/10.1016/j.ejphar.2013.03.005
https://doi.org/10.1016/j.ejphar.2013.03.005
Publikováno v:
Neuroscience. 169:87-97
This report investigates acute changes in the sensitivity of 5-HT(1A) receptors in dorsal raphe (dr) neurons in response to elevated serotonin. DR neurons were isolated from adult rats and measurements of inhibition of Ca(2+) current by 5-HT were obt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aec5efe76d96f6a9630b105e8d518d3c
https://doi.org/10.1016/j.neuroscience.2010.04.042
https://doi.org/10.1016/j.neuroscience.2010.04.042
Publikováno v:
Molecular Pharmacology. 73:42-49
TRPC5 channels are Ca(2+)-permeable nonselective cation channels activated by G-protein-coupled receptors, although the mechanisms responsible for channel activation and regulation are poorly understood. Carbachol-activated TRPC5 currents were record
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56f5273c5e77766a7444302cbb5d70ff
https://doi.org/10.1124/mol.107.040899
https://doi.org/10.1124/mol.107.040899
Publikováno v:
The Journal of Physiology. 538:41-51
The importance of specific protein kinase C (PKC) sites for modulation of the inhibitory coupling of 5-HT(1A) receptors to N-type Ca(2+) channels was examined using patch-clamp techniques in F11 rat dorsal root ganglion x mouse neuroblastoma hybrid c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::188acfdbff08c8405a4c0e90d7899991
https://doi.org/10.1113/jphysiol.2001.012668
https://doi.org/10.1113/jphysiol.2001.012668
Publikováno v:
Journal of Neurochemistry. 72:1489-1496
Previous studies have indicated that stimulation of neuronal inhibitory receptors, such as the serotonin 1A receptor (5-HT 1A -R), could cause attenuation of the activity of both N-type Ca 2+ channels and N-methyl-D-aspartic acid receptors, thus resu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bccc7be80ec1cccb6504cbf69a20d4e
https://doi.org/10.1046/j.1471-4159.1999.721489.x
https://doi.org/10.1046/j.1471-4159.1999.721489.x
Publikováno v:
Brain Research. 904:307-317
Extracellular ATP evoked two excitatory responses in hippocampal neuroblastoma cells (HN2). The first, an opening of a receptor-operated non-selective cation channel and the second was a leftward shift in Na+ channel activation. Both ATP (5-1000 micr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22031ba0cf97a523fa2244fae130136f
https://doi.org/10.1016/s0006-8993(01)02487-8
https://doi.org/10.1016/s0006-8993(01)02487-8