Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Nicholas J. P. Ryba"'
Publikováno v:
PLoS ONE, Vol 13, Iss 2, p e0193129 (2018)
Design and engineering of complex knockin mice has revolutionized the in vivo manipulation of genetically defined cells. Recently development of the bacterial clustered regularly interspersed short palindromic repeats (CRISPR) associated protein 9 (C
Externí odkaz:
https://doaj.org/article/7558862b04e64ec387d50696d8f2c3dd
Publikováno v:
PLoS ONE, Vol 12, Iss 9, p e0185543 (2017)
The trigeminal ganglion contains somatosensory neurons that detect a range of thermal, mechanical and chemical cues and innervate unique sensory compartments in the head and neck including the eyes, nose, mouth, meninges and vibrissae. We used single
Externí odkaz:
https://doaj.org/article/9383484cf79f4b478d185b9e4b732ada
Autor:
Alexander T. Chesler, Nicholas J. P. Ryba, Ruby M. Lam, Joshua J. Emrick, Lars J. von Buchholtz
Publikováno v:
Pain
Single cell sequencing has provided unprecedented information about the transcriptomic diversity of somatosensory systems. Here, we describe a simple and versatile in situ hybridization (ISH)-based approach for mapping this information back to the ti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ecd03244d1b5294a732d5f29dcfce9b
https://doi.org/10.1097/j.pain.0000000000001911
https://doi.org/10.1097/j.pain.0000000000001911
Publikováno v:
eLife, Vol 10 (2021)
eLife
eLife
Somatosensory neurons with cell bodies in the dorsal root ganglia (DRG) project to the skin, muscles, bones, and viscera to detect touch and temperature as well as to mediate proprioception and many types of interoception. In addition, the somatosens
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::083837f64d9b0da5e9eecbb13745149a
https://elifesciences.org/articles/71752
https://elifesciences.org/articles/71752
Somatosensory neurons with cell bodies in the dorsal root ganglia (DRG) project to the skin, muscles, bones, and viscera to detect touch and temperature as well as to mediate proprioception and many types of interoception. In addition, the somatosens
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dbacc313e9b0c401775f2295f604f066
https://doi.org/10.1101/2021.07.02.450845
https://doi.org/10.1101/2021.07.02.450845
Publikováno v:
J Dent Res
Toothache is a common painful consequence of damage to the teeth, particularly when coupled to infection. Clinical restoration of tooth integrity, sometimes involving physical and chemical sterilization of the tooth with nerve fiber ablation (i.e., e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c080ddbcb20a09d23c30b40019c7669f
https://europepmc.org/articles/PMC7684839/
https://europepmc.org/articles/PMC7684839/
Autor:
Minh Q Nguyen, Nicholas J P Ryba
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e41899 (2012)
In mammals, odorants are detected by a large family of receptors that are each expressed in just a small subset of olfactory sensory neurons (OSNs). Here we describe a strain of transgenic mice engineered to express an octanal receptor in almost all
Externí odkaz:
https://doaj.org/article/85fe62ed03044eaa80dd692a6dab2d81
Autor:
Yueqing Peng, Xiaoke Chen, Charles S. Zuker, Sarah Gillis-Smith, Li Wang, Nicholas J. P. Ryba, C. Daniel Salzman, Juen Zhang
Publikováno v:
Nature
The ability of the taste system to identify a tastant (what it tastes like) enables animals to recognize and discriminate between the different basic taste qualities1,2. The valence of a tastant (whether it is appetitive or aversive) specifies its he
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::440cc2ce59dfd7c69cdbb6ebf14b1a2d
http://europepmc.org/articles/PMC6201270
http://europepmc.org/articles/PMC6201270
Publikováno v:
Nature. 548:330-333
In mammals, taste buds typically contain 50-100 tightly packed taste-receptor cells (TRCs), representing all five basic qualities: sweet, sour, bitter, salty and umami. Notably, mature taste cells have life spans of only 5-20 days and, consequently,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f1c403e3d47e9065c12fdc3305ee587
https://doi.org/10.1038/nature23299
https://doi.org/10.1038/nature23299