Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Nicholas J. Otte"'
Autor:
Rachel-Ann A. Garibsingh, Nicholas J. Otte, Elias Ndaru, Claire Colas, Christof Grewer, Jeff Holst, Avner Schlessinger
Publikováno v:
Frontiers in Chemistry, Vol 6 (2018)
The Alanine-Serine-Cysteine transporter (SLC1A5, ASCT2), is a neutral amino acid exchanger involved in the intracellular homeostasis of amino acids in peripheral tissues. Given its role in supplying glutamine to rapidly proliferating cancer cells in
Externí odkaz:
https://doaj.org/article/0bbeedd4a4074319bf72ac4836368ba1
Autor:
Michelle van Geldermalsen, Charles G. Bailey, Andrew J. Hoy, Natalia Pinello, John E.J. Rasko, Martin E. Gleave, Nicholas J. Otte, Colleen C. Nelson, Martin C. Sadowski, Rae-Anne Hardie, Qian Wang, Dadi Gao, Seher Balaban, Justin J.-L. Wong, Mark Schreuder, Ladan Fazli, William Ritchie, Cynthia Metierre, Rajini Nagarajah, Melanie Lehman, Jeff Holst
Publikováno v:
The Journal of Pathology
Glutamine is conditionally essential in cancer cells, being utilized as a carbon and nitrogen source for macromolecule production, as well as for anaplerotic reactions fuelling the tricarboxylic acid (TCA) cycle. In this study, we demonstrated that t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98149121d0703c25df6280299eebad8e
https://doi.org/10.1002/path.4518
https://doi.org/10.1002/path.4518
Autor:
Kimberley A. Beaumont, Josep Font, Jeff Holst, Mika Jormakka, Nicholas J. Otte, Qian Wang, Renae M. Ryan, John E.J. Rasko, Michelle van Geldermalsen, Jessamy Tiffen, Charles G. Bailey, Nikolas K. Haass, Danae M. Sharp
Publikováno v:
International Journal of Cancer. 135:1060-1071
Amino acids, especially leucine and glutamine, are important for tumor cell growth, survival and metabolism. A range of different transporters deliver each specific amino acid into cells, some of which are increased in cancer. These amino acids conse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::26b996e0282b631ec9c3b03469f90867
https://doi.org/10.1002/ijc.28749
https://doi.org/10.1002/ijc.28749
Autor:
Amy D, Marshall, Michelle, van Geldermalsen, Nicholas J, Otte, Lyndal A, Anderson, Trina, Lum, Melissa A, Vellozzi, Blake K, Zhang, Annora, Thoeng, Qian, Wang, John E J, Rasko, Jeff, Holst
Publikováno v:
International journal of cancer. 139(11)
l-type amino acid transporters (LAT1-4) are expressed in various cancer types and are involved in the uptake of essential amino acids such as leucine. Here we investigated the expression of LAT1-4 in endometrial adenocarcinoma and evaluated the contr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::60172de77f45b3d5dc38acf173e21f0b
https://pubmed.ncbi.nlm.nih.gov/27486861
https://pubmed.ncbi.nlm.nih.gov/27486861
Autor:
Nicholas J. Otte, Angelika Bröer, Jeff Holst, Stefan Bröer, Qian Wang, Charles G. Bailey, Patrick O’Young, Michelle van Geldermalsen
Publikováno v:
Cancer Research. 76:1007-1007
Cancer cells utilize amino acids to satisfy their need for nutrients and fuel their accelerated growth. The amino acid glutamine has been identified as one of the key building blocks in cancer cells, utilized for macromolecular synthesis and energy p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::26da3d632f013b15d30b065949a93f18
https://doi.org/10.1158/1538-7445.am2016-1007
https://doi.org/10.1158/1538-7445.am2016-1007
Autor:
John E.J. Rasko, Lyndal Anderson, Rajini Nagarajah, Trina Lum, Blake K. Zhang, Nicholas J. Otte, M van Geldermalsen, Annora Thoeng, Amy D. Marshall, Qian Wang, Melissa Vellozzi, Jeff Holst, Angel Pang
Publikováno v:
Oncogenesis
Glutamine commonly becomes a conditionally essential amino acid in cancer. Glutamine is supplied to the cell by transporters such as ASCT2 (SLC1A5), which is frequently upregulated in multiple cancers. Here we investigated the expression of ASCT2 in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c4cf8e96324137b63cc1abb2d828a2f
http://europepmc.org/articles/PMC5541720
http://europepmc.org/articles/PMC5541720
Autor:
Qian, Wang, Kimberley A, Beaumont, Nicholas J, Otte, Josep, Font, Charles G, Bailey, Michelle, van Geldermalsen, Danae M, Sharp, Jessamy C, Tiffen, Renae M, Ryan, Mika, Jormakka, Nikolas K, Haass, John E J, Rasko, Jeff, Holst
Publikováno v:
International journal of cancer. 135(5)
Amino acids, especially leucine and glutamine, are important for tumor cell growth, survival and metabolism. A range of different transporters deliver each specific amino acid into cells, some of which are increased in cancer. These amino acids conse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2f01a91977245ac6d4c53436f4c1cc77
https://pubmed.ncbi.nlm.nih.gov/24531984
https://pubmed.ncbi.nlm.nih.gov/24531984
Autor:
Armanda Gameiro, Christof Grewer, Nicholas J. Otte, Thomas Albers, Helen Shere, Claire Colas, Kurnvir Singh, Jeff Holst, Massimiliano Bonomi, Avner Schlessinger
Publikováno v:
PLoS Computational Biology
PLoS Computational Biology, Vol 11, Iss 10, p e1004477 (2015)
PLoS Computational Biology, Vol 11, Iss 10, p e1004477 (2015)
The Alanine-Serine-Cysteine transporter ASCT2 (SLC1A5) is a membrane protein that transports neutral amino acids into cells in exchange for outward movement of intracellular amino acids. ASCT2 is highly expressed in peripheral tissues such as the lun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98e6408d0fbe1fad22946d22f67c05d8
https://doi.org/10.1371/journal.pcbi.1004477
https://doi.org/10.1371/journal.pcbi.1004477
Autor:
Marshall, Amy D., van Geldermalsen, Michelle, Otte, Nicholas J., Anderson, Lyndal A., Lum, Trina, Vellozzi, Melissa A., Zhang, Blake K., Thoeng, Annora, Wang, Qian, Rasko, John E.J., Holst, Jeff
Publikováno v:
International Journal of Cancer; Dec2016, Vol. 139 Issue 11, p2529-2539, 11p
Publikováno v:
Amino Acids; Aug2015, Vol. 47 Issue 8, p1607-1696, 90p